INT10169

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Context Info
Confidence 0.70
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 44
Total Number 44
Disease Relevance 27.71
Pain Relevance 16.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
microglia 6
cardiac myocyte 4
monocytes 3
livers 2
spinal cord 2
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 132 100.00 Very High Very High Very High
Inflammation 108 100.00 Very High Very High Very High
headache 14 100.00 Very High Very High Very High
aspirin 21 99.98 Very High Very High Very High
Clonidine 12 99.98 Very High Very High Very High
Perioperative pain 2 99.96 Very High Very High Very High
intrathecal 10 99.70 Very High Very High Very High
Cannabinoid 9 99.62 Very High Very High Very High
Central nervous system 3 99.12 Very High Very High Very High
Inflammatory mediators 13 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 136 100.00 Very High Very High Very High
Necrosis 59 100.00 Very High Very High Very High
Cancer 50 100.00 Very High Very High Very High
Nervous System Injury 28 99.98 Very High Very High Very High
Post Operative Pain 2 99.96 Very High Very High Very High
Diabetes Mellitus 60 99.92 Very High Very High Very High
Headache 14 99.84 Very High Very High Very High
Ulcers 20 99.76 Very High Very High Very High
Stress 17 99.76 Very High Very High Very High
Injury 121 99.50 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results indicate that both NE and clonidine increased TNF-alpha release by approximately 4-7-fold in the isolated cultured Kupffer cells.
Positive_regulation (increased) of Localization (release) of TNF-alpha in Kupffer cells associated with clonidine
1) Confidence 0.70 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.28 Pain Relevance 0.29
Bacterial lipopolysaccharide (LPS) stimulates massive release of tumor necrosis factor-alpha (TNF-alpha) together with nitric oxide (NO) and a lessor release of leptin.
Positive_regulation (stimulates) of Localization (release) of tumor necrosis factor-alpha associated with necrosis and cancer
2) Confidence 0.67 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11368420 Disease Relevance 0.52 Pain Relevance 0.29
The suppressive action of bromoergocryptine, a dopamine D2 receptor agonist, on LPS-induced TNF-alpha release may be mediated in part by suppression of prolactin release, which triggers TNF-alpha release.


Positive_regulation (triggers) of Localization (release) of TNF-alpha
3) Confidence 0.67 Published 2001 Journal Neuroimmunomodulation Section Body Doc Link 11752888 Disease Relevance 0 Pain Relevance 0
Lipopolysaccharide-induced tumor necrosis factor-alpha release is controlled by the central nervous system.
Positive_regulation (induced) of Localization (release) of tumor necrosis factor-alpha in central nervous system associated with necrosis, cancer and central nervous system
4) Confidence 0.67 Published 2001 Journal Neuroimmunomodulation Section Title Doc Link 11752888 Disease Relevance 0.47 Pain Relevance 0.33
LPS alone caused a concentration-dependent increase in TNF-alpha release but had no significant effect on the release of PGE(2).
Positive_regulation (caused) of Localization (release) of TNF-alpha
5) Confidence 0.63 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.42 Pain Relevance 0.29
CPZ alone caused a concentration-dependent increase in TNF-alpha release, which was approximately additive in the presence of LPS.
Positive_regulation (increase) of Localization (release) of TNF-alpha
6) Confidence 0.63 Published 2006 Journal Toxicol In Vitro Section Abstract Doc Link 16782301 Disease Relevance 0.35 Pain Relevance 0.24
Tumor necrosis factor-alpha release in explant medium increased from 0.02 +/- 0.03 pg/mg in 6 controls to 0.28 +/- 0.15 pg/mg in 14 animals after treatment with protamine sulfate/lipopolysaccharide and it decreased to 0.12 +/- 0.11 pg/mg in 10 animals pretreated with nanocrystalline silver (p = 0.009).
Positive_regulation (increased) of Localization (release) of Tumor necrosis factor-alpha
7) Confidence 0.50 Published 2008 Journal J. Urol. Section Body Doc Link 18295255 Disease Relevance 0.06 Pain Relevance 0
Aspirin ingestion impairs oral mucosal ulcer healing by inducing membrane-bound tumor necrosis factor-alpha release.
Positive_regulation (inducing) of Localization (release) of tumor necrosis factor-alpha associated with aspirin, necrosis, cancer and ulcers
8) Confidence 0.50 Published 2000 Journal IUBMB Life Section Title Doc Link 11327313 Disease Relevance 1.18 Pain Relevance 0.47
BACKGROUND: Although previous studies indicate that prevention of tumour necrosis factor alpha (TNFalpha) release protects against NSAID-induced gastric mucosal injury, intracellular pathways by which aspirin causes TNFalpha release are unknown.
Positive_regulation (causes) of Localization (release) of TNFalpha associated with aspirin, necrosis, cancer, injury and cinod
9) Confidence 0.49 Published 1998 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 9845404 Disease Relevance 0.37 Pain Relevance 0.23
Increased spontaneous release of tumor necrosis factor-alpha/cachectin in headache patients.
Positive_regulation (Increased) of Localization (release) of tumor necrosis factor-alpha/cachectin associated with necrosis, cancer and headache
10) Confidence 0.49 Published 1991 Journal Int. J. Neurosci. Section Title Doc Link 1667186 Disease Relevance 0.99 Pain Relevance 0.70
Decrease in elevated TNF-?
Positive_regulation (elevated) of Localization (Decrease) of TNF
11) Confidence 0.49 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991700 Disease Relevance 1.19 Pain Relevance 0.09
However, the role of increased fluid clearance with inflammatory cytokines such as TNF-?
Positive_regulation (increased) of Localization (clearance) of TNF associated with inflammation and cytokine
12) Confidence 0.49 Published 2004 Journal Crit Care Section Body Doc Link PMC522843 Disease Relevance 1.27 Pain Relevance 0.47
Thirty minutes of global ischemia and 40 min of reperfusion caused a dramatic decrease in myocardial function, and a significant increase in the release of cardiac creatine kinase in the coronary effluent and in the content of tumor necrosis factor-alpha (TNF-alpha) in myocardial tissues.
Positive_regulation (increase) of Localization (release) of tumor necrosis factor-alpha associated with necrosis, cancer and ischemia
13) Confidence 0.49 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11068026 Disease Relevance 0.54 Pain Relevance 0.54
Similarly to L4-L5 DRG, an increase in the level of TNF-?
Positive_regulation (increase) of Localization (level) of TNF
14) Confidence 0.49 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.65 Pain Relevance 0.44
Despite aggressive fluid resuscitation, burn trauma produced a time-related increase in cardiomyocyte secretion of IL-1beta, IL-6, and TNF-alpha.
Positive_regulation (increase) of Localization (secretion) of TNF-alpha in cardiomyocyte associated with burns and injury
15) Confidence 0.48 Published 2002 Journal Shock Section Abstract Doc Link 12392281 Disease Relevance 1.05 Pain Relevance 0.46
SP induced a gradual increase at 10(-7) mol/L in the expression of GFAP in the spinal cord astrocytes at 0 -72 h, significantly different from that of the control group (P < 0.01), and it promoted the excretion of TNF-alpha and IL-1beta and the activity of NO and NOS at 10(-9) - 10(-6) mol/L at 12 h in a concentration-dependent manner, with marked differences between the experiment and control groups (P < 0.01, P < 0.05).
Positive_regulation (promoted) of Localization (excretion) of TNF-alpha in spinal cord
16) Confidence 0.47 Published 2009 Journal Zhonghua Nan Ke Xue Section Body Doc Link 20218316 Disease Relevance 0 Pain Relevance 0
Similarly, intraportal infusion of NE in vivo or in isolated livers increased TNF-alpha synthesis and release which was inhibited by co-infusion of yohimbine.
Positive_regulation (increased) of Localization (release) of TNF-alpha in livers
17) Confidence 0.47 Published 2001 Journal Biochim. Biophys. Acta Section Abstract Doc Link 11476962 Disease Relevance 0.17 Pain Relevance 0.27
Bacterial lipopolysaccharide (LPS) stimulates massive release of tumor necrosis factor-alpha (TNF-alpha) together with nitric oxide (NO) and a lessor release of leptin.
Positive_regulation (stimulates) of Localization (release) of TNF-alpha associated with necrosis and cancer
18) Confidence 0.46 Published 2001 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 11368420 Disease Relevance 0.52 Pain Relevance 0.29
TNFalpha processing enzyme inhibitors prevent aspirin-induced TNFalpha release and protect against gastric mucosal injury in rats.
Positive_regulation (induced) of Localization (release) of TNFalpha associated with aspirin and injury
19) Confidence 0.46 Published 1998 Journal Aliment. Pharmacol. Ther. Section Title Doc Link 9845404 Disease Relevance 0.38 Pain Relevance 0.28
Agents that cause Ca2+ mobilization with a receptor-independent mechanism, such as ionomycin and thapsigargin, stimulate TNFalpha release.
Positive_regulation (stimulate) of Localization (release) of TNFalpha
20) Confidence 0.46 Published 1998 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 9845404 Disease Relevance 0.06 Pain Relevance 0

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