INT101699

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 3.70
Pain Relevance 7.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora1) endoplasmic reticulum (Adora1) plasma membrane (Adora1)
signal transducer activity (Adora1)
Anatomy Link Frequency
Peripheral nerve 1
Adora1 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 469 100.00 Very High Very High Very High
antagonist 96 100.00 Very High Very High Very High
Analgesic 6 100.00 Very High Very High Very High
Peripheral nerve injury 1 99.82 Very High Very High Very High
Antinociceptive 102 99.64 Very High Very High Very High
cocaine 42 99.60 Very High Very High Very High
agonist 120 99.50 Very High Very High Very High
antiallodynic 24 99.44 Very High Very High Very High
Spinal cord 36 99.40 Very High Very High Very High
depression 60 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Sleep Disorders 12 99.92 Very High Very High Very High
Nervous System Injury 15 99.82 Very High Very High Very High
Depression 63 99.26 Very High Very High Very High
Pain 29 96.36 Very High Very High Very High
Neuropathic Pain 14 94.64 High High
Nociception 29 92.28 High High
Drug Induced Neurotoxicity 6 91.52 High High
INFLAMMATION 20 90.80 High High
Hypersensitivity 1 87.52 High High
Targeted Disruption 13 87.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral nerve injury did not change the level of adenosine A1 receptor in the dorsal spinal cord in rats and i.t. administration of R-PIA effectively alleviated pain-like behaviors after partial nerve injury in rats and in C57/BL/6 mice.
Neg (not) Regulation (change) of adenosine A1 receptor in Peripheral nerve associated with pain, adenocard, nervous system injury, spinal cord and peripheral nerve injury
1) Confidence 0.61 Published 2005 Journal Pain Section Abstract Doc Link 15661449 Disease Relevance 0.95 Pain Relevance 1.25
In support of an A1R-dependent mechanism, we found that intrathecal (i.t.) injection of secretory PAP protein (from mouse or human) into wild-type mice had long lasting antinociceptive, antihyperalgesic and antiallodynic effects that were entirely dependent on A1R activation [10,11].
Regulation (dependent) of A1R associated with antihyperalgesic, antiallodynic, antinociceptive and intrathecal
2) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0.87 Pain Relevance 0.99
We previously found that a single intrathecal injection of PAP had antinociceptive, antihyperalgesic and antiallodynic effects that lasted for three days and that were dependent on A1R activation [10,11].
Regulation (dependent) of A1R associated with antihyperalgesic, antiallodynic, antinociceptive and intrathecal
3) Confidence 0.44 Published 2010 Journal Mol Pain Section Body Doc Link PMC2874211 Disease Relevance 0 Pain Relevance 0.32
In this study, the functionality of A1Rs was not affected by NMDA preconditioning, but this treatment promoted A2AR desensitization in concert with A1R activation [83].
Neg (not) Regulation (affected) of A1R
4) Confidence 0.44 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.17 Pain Relevance 0.51
The purpose of this study was to examine factors that may contribute to, or interact with, A1R-mediated depression of preBötC rhythmogenesis including effects of A1R activation on synaptic transmission and membrane properties.
Regulation (effects) of A1R associated with depression
5) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.10 Pain Relevance 0.26
When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A1-adenosine receptor (A1R) activation.
Regulation (dependent) of A1R associated with adenocard and antinociceptive
6) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617779 Disease Relevance 0.09 Pain Relevance 0.35
When injected intraspinally, the secretory isoforms of human and bovine PAP protein have potent and long-lasting antinociceptive effects that are dependent on A1-adenosine receptor (A1R) activation.
Regulation (dependent) of A1-adenosine receptor associated with adenocard and antinociceptive
7) Confidence 0.37 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2617779 Disease Relevance 0.09 Pain Relevance 0.35
Effects of A1R agonism/antagonism on preBötC population activity in slice preparations
Regulation (Effects) of A1R
8) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.17 Pain Relevance 0.25
Effects of A1R agonism/antagonism on preBötC population activity in island preparations
Regulation (Effects) of A1R
9) Confidence 0.34 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2567986 Disease Relevance 0.21 Pain Relevance 0
The effects of adenosine A1 and A2A receptor agonists and antagonists administered intraperitoneally (i.p.) and their interaction with angiotensin II (Ang II) administered intracerebroventricularly (i.c.v.) were studied in mice using the acetic acid-induced abdominal constriction test.
Regulation (effects) of adenosine A1 associated with adenocard, antagonist and agonist
10) Confidence 0.31 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11900765 Disease Relevance 0 Pain Relevance 0.39
Whereas A1R KO mice appear to be more responsive to cocaine than wild type animals the opposite is known to be true for A2AR KO mice since several previous reports, from our and other groups, have demonstrated decreased response to cocaine or amphetamine in animals that lack A2A receptor gene [14], [15].
Regulation ( more resp) of A1R associated with cocaine
11) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597749 Disease Relevance 0 Pain Relevance 0.41
Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor.
Regulation (regulation) of adenosine A1 receptor associated with adenocard
12) Confidence 0.26 Published 2003 Journal J Sleep Res Section Title Doc Link 14633239 Disease Relevance 0.72 Pain Relevance 0.44
Involvement of adenosine A1 and A2A receptors in (-)-linalool-induced antinociception.
Regulation (Involvement) of adenosine A1 associated with antinociception, adenocard and analgesic
13) Confidence 0.26 Published 2006 Journal Life Sci. Section Title Doc Link 16343551 Disease Relevance 0.09 Pain Relevance 0.79
The binding for selective A1R agonists was decreased while the A1R antagonist binding remained unaffected.
Neg (unaffected) Regulation (unaffected) of A1R associated with antagonist and agonist
14) Confidence 0.08 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.09 Pain Relevance 0.48
They therefore suggested that the modulation of the A1R-mediated response by activation of GABAA receptors occurs indirectly via NO [19].
Regulation (modulation) of A1R
15) Confidence 0.05 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.15 Pain Relevance 0.79

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