INT101701

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.30
Pain Relevance 3.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2a) plasma membrane (Adora2a) enzyme binding (Adora2a)
signal transducer activity (Adora2a)
Anatomy Link Frequency
neurons 1
striatum 1
bone marrow 1
lung 1
Adora2a (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 116 100.00 Very High Very High Very High
antagonist 60 100.00 Very High Very High Very High
Neuropeptide 3 100.00 Very High Very High Very High
agonist 50 99.96 Very High Very High Very High
withdrawal 4 99.24 Very High Very High Very High
Morphine 6 99.02 Very High Very High Very High
Cannabinoid 1 98.92 Very High Very High Very High
narcan 2 98.62 Very High Very High Very High
Inflammation 124 97.00 Very High Very High Very High
Enkephalin 4 96.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 7 99.68 Very High Very High Very High
Disease 26 98.04 Very High Very High Very High
INFLAMMATION 102 97.00 Very High Very High Very High
Neurodegenerative Disease 1 94.60 High High
Lung Injury 70 92.20 High High
Opiate Addiction 2 86.84 High High
Anxiety Disorder 1 73.12 Quite High
Morphine Dependence 1 69.56 Quite High
Drug Dependence 4 58.80 Quite High
Adult Respiratory Distress Syndrome 38 47.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the decreased up-regulation of A2AR-specific mRNA that was observed in parallel with an increased A1 receptor-specific mRNA expression in inflammatory granulocytes from mice breathing pure oxygen is in support of hyperoxic exacerbation of lung injury.


Regulation (regulation) of A2AR-specific in lung associated with lung injury and inflammation
1) Confidence 0.45 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.45 Pain Relevance 0.21
As expected, significant up-regulation of A2AR was observed in experiments in which CGS21680 greatly enhanced the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP)-stimulated cAMP production of in vivo-activated neutrophils isolated from inflamed lungs from wild-type mice, but not of naïve granulocytes obtained from the bone marrow of healthy wild-type control mice (Figure 4B, left graph).
Regulation (regulation) of A2AR in bone marrow
2) Confidence 0.45 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1088279 Disease Relevance 0.06 Pain Relevance 0.13
A2A receptor and striatal cellular functions: regulation of gene expression, currents, and synaptic transmission.
Regulation (regulation) of A2A associated with neuropeptide
3) Confidence 0.44 Published 2003 Journal Neurology Section Title Doc Link 14663005 Disease Relevance 0.34 Pain Relevance 0.37
Since caffeine and selective A2A antagonists induce the reinforcement and sensitization behaviors, and exhibit the therapeutic effects in animal models of PD, which are mediated by mesolimic and nigrostrial dopaminergic pathways projected to the striatum, it is reasonable to hypothesize that caffeine and selective A2A antagonists can modulate the neuroadaptation of dopaminergic neurons in the striatum.
Regulation (modulate) of A2A in striatum associated with antagonist and disease
4) Confidence 0.27 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2843608 Disease Relevance 0.30 Pain Relevance 0.62
A separate quantitative PCR analysis of genes in the last of these groups confirms the dysregulation of both orphan (Gpr88) and known (DrD1A, Adora2A, Cnr1, Grm5, Gpr6) G protein-coupled receptors, scaffolding (PSD95, Homer1) and signaling (Sgk, Cap1) proteins, and neuropeptides (CCK, galanin).
Regulation (dysregulation) of Adora2A associated with neuropeptide
5) Confidence 0.26 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18588537 Disease Relevance 0.18 Pain Relevance 0.74
Analysis of gene expression regulation using pharmacologic tools or A2A receptor-deficient mice (A2A-/-) shows that the A2A receptor positively and tonically controls the expression of enkephalin and immediate early genes in striatopallidal neurons.
Regulation (regulation) of A2A in neurons associated with enkephalin
6) Confidence 0.23 Published 2003 Journal Neurology Section Abstract Doc Link 14663005 Disease Relevance 0.36 Pain Relevance 0.30
The effects of adenosine A1 and A2A receptor agonists and antagonists administered intraperitoneally (i.p.) and their interaction with angiotensin II (Ang II) administered intracerebroventricularly (i.c.v.) were studied in mice using the acetic acid-induced abdominal constriction test.
Regulation (effects) of A2A receptor associated with adenocard, antagonist and agonist
7) Confidence 0.18 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11900765 Disease Relevance 0 Pain Relevance 0.40
Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice.
Neg (no) Regulation (changes) of A2a associated with targeted disruption, narcan, withdrawal and morphine
8) Confidence 0.17 Published 2003 Journal Eur. J. Neurosci. Section Title Doc Link 12542668 Disease Relevance 0.60 Pain Relevance 0.86

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox