INT101705

Context Info Confidence 0.03 First Reported 2002 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0 Pain Relevance 0.59

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)

Anatomy Link Frequency boutons 2 Kcnma1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Action potential 1 99.42 gABA 2 98.50 tetrodotoxin 4 97.28 GABAergic 3 89.32 lidocaine 2 78.64

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Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The GABA release from the boutons was action potential dependent since eIPSCs were blocked in the presence of either voltage-dependent Na(+) or Ca(2+)channel blocker.

Negative_regulation (blocked) of Positive_regulation (voltage-dependent) of channel in boutons associated with action potential and gaba

1) Confidence 0.03 Published 2002 Journal Neurosci. Res. Section Abstract Doc Link 11900828 Disease Relevance 0 Pain Relevance 0.36

In this study, we sought to elucidate the molecular mechanisms underlying Rg(3)-induced Na(+) channel inhibition.

Negative_regulation (inhibition) of Positive_regulation (-induced) of channel

2) Confidence 0.01 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16014805 Disease Relevance 0 Pain Relevance 0.23

General Comments

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