INT101705

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Anatomy Link Frequency
boutons 2
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Action potential 1 99.42 Very High Very High Very High
gABA 2 98.50 Very High Very High Very High
tetrodotoxin 4 97.28 Very High Very High Very High
GABAergic 3 89.32 High High
lidocaine 2 78.64 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The GABA release from the boutons was action potential dependent since eIPSCs were blocked in the presence of either voltage-dependent Na(+) or Ca(2+)channel blocker.
Negative_regulation (blocked) of Positive_regulation (voltage-dependent) of channel in boutons associated with action potential and gaba
1) Confidence 0.03 Published 2002 Journal Neurosci. Res. Section Abstract Doc Link 11900828 Disease Relevance 0 Pain Relevance 0.36
In this study, we sought to elucidate the molecular mechanisms underlying Rg(3)-induced Na(+) channel inhibition.
Negative_regulation (inhibition) of Positive_regulation (-induced) of channel
2) Confidence 0.01 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16014805 Disease Relevance 0 Pain Relevance 0.23

General Comments

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