INT101707

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.99
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FGF4) extracellular region (FGF4) cell-cell signaling (FGF4)
Anatomy Link Frequency
heart 2
blood 1
fibroblast 1
FGF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 18 98.96 Very High Very High Very High
gABA 2 93.40 High High
Neurotransmitter 1 92.20 High High
ischemia 23 88.68 High High
Pain 5 83.08 Quite High
Potency 7 79.84 Quite High
agonist 1 76.56 Quite High
Spinal cord 14 75.00 Quite High
allodynia 1 75.00 Quite High
Hyperalgesia 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Cancer 1 100.00 Very High Very High Very High
Hemangioma 2 99.52 Very High Very High Very High
Myocardial Infarction 17 99.32 Very High Very High Very High
Retinal Neovascularization 2 99.04 Very High Very High Very High
Cv General 3 Under Development 17 98.96 Very High Very High Very High
Coronary Heart Disease 6 97.92 Very High Very High Very High
Stress 9 94.44 High High
Coronary Artery Disease 26 88.68 High High
Fever 2 87.92 High High
Cytomegalovirus Infection 4 85.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a blinded placebo-controlled study in a pig model of pacing-induced heart failure, intracoronary delivery of human FGF-4 expressed in an adenovirus vector showed significant improvement in regional cardiac function and a reduction in the size of the heart over a 3-week study period.
Gene_expression (expressed) of FGF-4 in heart associated with myocardial infarction
1) Confidence 0.78 Published 2002 Journal BioDrugs Section Abstract Doc Link 11909005 Disease Relevance 0.60 Pain Relevance 0.07
FGF-4 gene expression was detected in the heart but not at extracardiac sites.
Gene_expression (expression) of FGF-4 in heart
2) Confidence 0.77 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 14615023 Disease Relevance 0.80 Pain Relevance 0.32
FGF-4 was not detected in venous blood.
Neg (not) Gene_expression (detected) of FGF-4 in blood
3) Confidence 0.77 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 14615023 Disease Relevance 0.92 Pain Relevance 0.30
This new cell line, hNT2.17, expresses an exclusively neuronal phenotype, does not incorporate bromodeoxyuridine during differentiation, and does not express the tumor-related proteins fibroblast growth factor 4 and transforming growth factor-alpha during differentiation after 2 weeks of treatment with retinoic acid and mitotic inhibitors.
Neg (not) Gene_expression (express) of fibroblast growth factor 4 in fibroblast associated with cancer
4) Confidence 0.68 Published 2007 Journal J Pain Section Abstract Doc Link 17207742 Disease Relevance 1.04 Pain Relevance 0.81
Angiogenic gene transfer with Ad5-FGF4 shows promise as a new therapeutic approach to the treatment of angina pectoris.


Gene_expression (transfer) of Ad5-FGF4
5) Confidence 0.53 Published 2002 Journal Circulation Section Body Doc Link 11901038 Disease Relevance 0 Pain Relevance 0
We evaluated the expression of Oct4 (POU5F1) to determine whether exogenic Oct4 induced the expression of early developmental genes KLF4, Sox-2, Rex-1, Utf1, Dapp5, FGF4, ERas, and Nanog in cultured ATSCs (Fig. 1E).
Gene_expression (expression) of FGF4
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.25 Pain Relevance 0.04
In one essential test conducted to determine whether low oxygen/DHP-d induced the expression of early developmental genes in cultured ATSC, we evaluated the expression of Oct-4 (POU5F1), Sox-2, Rex-1, MMP2, TERT, Utf1, Dapp5, FGF4, ERas, and Nanog genes (Figure 1D, Figure 2).
Gene_expression (expression) of FGF4
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.05 Pain Relevance 0
The angiogenic gene therapy (AGENT) studies have addresses the safety and efficacy of the non-surgical, intracoronary injection of an Ad vector expressing FGF4 (Ad5FGF4) in patients with stable angina.
Gene_expression (expressing) of FGF4 associated with angina
8) Confidence 0.18 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.16 Pain Relevance 0.10
The angiogenic gene therapy (AGENT) studies have addresses the safety and efficacy of the non-surgical, intracoronary injection of an Ad vector expressing FGF4 (Ad5FGF4) in patients with stable angina.
Gene_expression (expressing) of Ad5FGF4 associated with angina
9) Confidence 0.16 Published 2007 Journal International Journal of Nanomedicine Section Body Doc Link PMC2676804 Disease Relevance 0.16 Pain Relevance 0.10

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