INT10171

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Context Info
Confidence 0.36
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 33
Total Number 33
Disease Relevance 19.84
Pain Relevance 5.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

RNA binding (Gtf3a) nucleus (Gtf3a) intracellular (Gtf3a)
DNA binding (Gtf3a)
Anatomy Link Frequency
platelet 2
nerve 2
cartilage 1
bone marrow 1
neural 1
Gtf3a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 14 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Hyperalgesia 8 99.40 Very High Very High Very High
Analgesic 10 98.44 Very High Very High Very High
withdrawal 4 97.88 Very High Very High Very High
agonist 15 97.30 Very High Very High Very High
cva 28 97.28 Very High Very High Very High
cytokine 44 97.20 Very High Very High Very High
COX2 1 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ulcers 5 100.00 Very High Very High Very High
Anaemia 1 100.00 Very High Very High Very High
Metabolic Syndrome 25 99.92 Very High Very High Very High
Abdominal Obesity 4 99.80 Very High Very High Very High
Hypertension 363 99.74 Very High Very High Very High
Rheumatoid Arthritis 92 99.72 Very High Very High Very High
Obesity 10 99.54 Very High Very High Very High
Hypersensitivity 3 99.44 Very High Very High Very High
Aseptic Necrosis Of Bone 55 99.42 Very High Very High Very High
Hyperalgesia 16 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PA interacts with both receptors through a common von Willebrand factor A/integrin-like inserted (I) domain that contains a metal ion adhesion site (MIDAS) with five metal ion coordinating residues [30].
von Willebrand factor A Binding (interacts) of associated with adhesions
1) Confidence 0.36 Published 2006 Journal PLoS Pathogens Section Body Doc Link PMC1617126 Disease Relevance 0.81 Pain Relevance 0
Anti-leukemia inhibitory factor had no effect upon hindpaw withdrawal thresholds when injected alone nor influenced the mechanical hypersensitivity produced by a subcutaneous injection of nerve growth factor.
factor Binding (injection) of in nerve associated with leukemia, nerve growth factor, hypersensitivity and withdrawal
2) Confidence 0.30 Published 1996 Journal Neuroscience Section Abstract Doc Link 8684613 Disease Relevance 1.08 Pain Relevance 0.67
Effectiveness of polyamidoamine dendrimers modified with tripeptide growth factor, glycyl-L-histidyl-L-lysine, for enhancement of function of hepatoma cells.
factor Binding (modified) of associated with hepatocellular cancer
3) Confidence 0.15 Published 1999 Journal J. Biosci. Bioeng. Section Title Doc Link 16232640 Disease Relevance 0.32 Pain Relevance 0.07
This repeat-binding factor was also shown to be developmentally upregulated specifically in pachytene spermatocytes.
factor Binding (binding) of in spermatocytes
4) Confidence 0.14 Published 2000 Journal Mol. Reprod. Dev. Section Abstract Doc Link 11013429 Disease Relevance 0.08 Pain Relevance 0
We propose that this DNA binding factor, termed PACH1, is a key transcriptional regulator of the proenkephalin and potentially other gene promoters, uniquely expressed during meiosis in the male germ line.
factor Binding (binding) of in germ line
5) Confidence 0.14 Published 2000 Journal Mol. Reprod. Dev. Section Abstract Doc Link 11013429 Disease Relevance 0.07 Pain Relevance 0
Here, footprinting analyses were used to further delineate the specific interactions of a spermatogenic cell nuclear factor with the repeat elements within the proximal promoter region.
factor Binding (interactions) of in proximal
6) Confidence 0.14 Published 2000 Journal Mol. Reprod. Dev. Section Abstract Doc Link 11013429 Disease Relevance 0.09 Pain Relevance 0
Mechanisms underlying the hyperalgesia induced by a single systemic injection of nerve growth factor (NGF) in adult rats were studied in vivo.
factor Binding (injection) of in nerve associated with hyperalgesia and nerve growth factor
7) Confidence 0.05 Published 1994 Journal Eur. J. Neurosci. Section Abstract Doc Link 7704300 Disease Relevance 0.45 Pain Relevance 0.70
The ventral population was identified as comprising neurons that express CRF and/or enkephalin and, to a lesser extent, growth hormone-releasing factor.
factor Binding (neurons) of in neurons associated with enkephalin
8) Confidence 0.05 Published 2002 Journal J. Comp. Neurol. Section Abstract Doc Link 11920708 Disease Relevance 0.30 Pain Relevance 0.13
To investigate the interaction between PAF, TNF-alpha and myocardial depressant factor, the blood levels of these three mediators were evaluated: shocked rats exhibited increased PAF levels with a peak at 30 min.
factor Binding (interaction) of in blood
9) Confidence 0.04 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1468489 Disease Relevance 0.71 Pain Relevance 0.04
Epidermal growth factor (EGF) is a potent mitogen implicated in gastroprotection and ulcer healing, but its possible interaction with nitric oxide (NO) and sensory nerves on healing after acute gastric damage has not been assessed.
factor Neg (NO) Binding (interaction) of in sensory nerves associated with ulcers
10) Confidence 0.04 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9479624 Disease Relevance 0.34 Pain Relevance 0.24
PURPOSE: This study was designed to determine at the molecular level whether interactions between the opioid growth factor (OGF) and OGF receptor (OGFr) play a role in regulating DNA synthesis in the homeostasis of the corneal epithelium.
factor Binding (interactions) of in corneal epithelium associated with opioid
11) Confidence 0.04 Published 2005 Journal Cornea Section Abstract Doc Link 15968171 Disease Relevance 0 Pain Relevance 0.17
In conjunction with factor VIIa, TF activates FXa directly (the extrinsic pathway) or via propagation of the tenase complex (factor VIIIa + factor IXa) on an activated platelet membrane (the intrinsic pathway) (Mann et al 2003).
factor VIIIa + factor IXa Binding (propagation) of in platelet
12) Confidence 0.03 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2597756 Disease Relevance 0.06 Pain Relevance 0
Glial cell line-derived neurotrophic factor (GDNF) has a variety of functions affecting the survival and development of specified neural cell populations, mediated via transmission of intracellular signals through binding to its high-affinity receptor, GFR*1, and subsequent activation of a tyrosine receptor kinase, RET, neural cell adhesion molecule (NCAM), or other signaling molecules.
factor Binding (binding) of in neural associated with adhesions
13) Confidence 0.03 Published 2008 Journal Pain Section Abstract Doc Link 17967506 Disease Relevance 0.77 Pain Relevance 0.89
The synovial fibroblasts in the distended joint capsule of rats with vessel-deprived osteonecrosis of the femoral head are jam-packed with vascular endothelial growth factor.
factor Binding (packed) of in head associated with aseptic necrosis of bone
14) Confidence 0.02 Published 2005 Journal Theor Biol Med Model Section Body Doc Link PMC1208957 Disease Relevance 0.38 Pain Relevance 0.04
Matrix and cell surface proteoglycans (PGs) may play important roles in the control of cellular actions of heparan-binding growth factors such as fibroblast growth factor (FGF) during chondrogenesis and osteogenesis, as the inhibition of PG synthesis resulted in reduced incorporation of chondroitin sulfate into cartilage and bone matrix, that was associated with a 75% reduction in cell growth in condyle (equivalent to a reduced volume), determined by DNA synthesis, and in collagenous matrix synthesis in condyle, evaluated by immunohistochemistry.
factor Binding (binding) of in cartilage
15) Confidence 0.02 Published 2010 Journal BMC Med Imaging Section Body Doc Link PMC3019198 Disease Relevance 0.09 Pain Relevance 0.09
Vascular endothelial growth factor (VEGF) has been identified as a validated target for several retinal vascular diseases, including CNV [4-12].
factor Binding (target) of associated with age-related macular degeneration and increased venous pressure under development
16) Confidence 0.02 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2746267 Disease Relevance 1.60 Pain Relevance 0.05
This means that over-representation of a certain binding site for one transcription factor in a gene promoter region may not always predict the binding of the exact same factor.


factor Binding (binding) of
17) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0 Pain Relevance 0.07
The effect of EGF is mediated by the RNA-binding protein Grb7 (growth factor receptor–bound protein 7), which serves as an adaptor for a specific mRNA–protein export complex and a translational regulator.
factor Binding (binding) of
18) Confidence 0.01 Published 2010 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2819679 Disease Relevance 0.06 Pain Relevance 0.04
Our results show that local administration of WIN 55,212-2, a CB(1)/CB(2) agonist, given daily or at time of implantation significantly decreased weight and neo-angiogenesis in granuloma tissue and inhibited nuclear factor-kappa B (NF-kappaB)/DNA binding that was associated with a reduced inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX-2), tumor necrosis factor alpha (TNF-alpha), and vascular endothelial growth factor (VEGF) messenger RNA (mRNA) and protein expression.
factor Binding (binding) of associated with necrosis, cancer, agonist, cox2 and granuloma
19) Confidence 0.01 Published 2007 Journal J. Mol. Med. Section Abstract Doc Link 17447045 Disease Relevance 0.84 Pain Relevance 0.54
B p65 and in turn inhibits binding of either transcription factor to its binding site [23].
factor Binding (binding) of
20) Confidence 0.01 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.55 Pain Relevance 0.10

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