INT101715

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Context Info
Confidence 0.11
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.99
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PLAT, NFKB1) nucleoplasm (NFKB1) mitochondrion (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) extracellular space (PLAT)
PLAT (Homo sapiens)
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 10 99.52 Very High Very High Very High
opioid receptor 6 99.52 Very High Very High Very High
Inflammation 4 81.12 Quite High
cocaine 1 78.48 Quite High
cINOD 2 75.80 Quite High
cytokine 5 75.60 Quite High
mu opioid receptor 1 73.20 Quite High
analgesia 1 70.32 Quite High
Opioid 1 69.48 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 98.44 Very High Very High Very High
Prostate Cancer 4 87.96 High High
Apoptosis 4 81.56 Quite High
INFLAMMATION 4 81.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.
TPA Positive_regulation (induced) of NF-kappa B associated with kinase c
1) Confidence 0.11 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.44 Pain Relevance 0.24
Pretreatment with protein kinase C (PKC) inhibitor blocked the TPA-induced increase in NAG-1 protein levels and NF-kappa B binding/transcriptional activity, whereas an inhibition of p38, JNK, MEK activity had no effect on TPA-induced NAG-1 levels and NF-kappa B transcriptional activity.
TPA Positive_regulation (increase) of NF-kappa B associated with kinase c
2) Confidence 0.11 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.45 Pain Relevance 0.25
In this report, we show that TPA activates AP-1 as well as the transcription factor nuclear factor kappaB (NFkappaB) in the mu-opioid receptor expressing neuroblastoma cell line SH SY5Y.
TPA Positive_regulation (activates) of NFkappaB associated with neuroblastoma and opioid receptor
3) Confidence 0.06 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11901219 Disease Relevance 0.10 Pain Relevance 0.60

General Comments

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