INT101718

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Context Info
Confidence 0.22
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.61

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Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) signal transducer activity (OPRM1)
cytoplasm (PLAT) extracellular space (PLAT) protein modification process (PLAT)
PLAT (Homo sapiens)
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 6 100.00 Very High Very High Very High
Kinase C 2 99.24 Very High Very High Very High
cocaine 1 96.32 Very High Very High Very High
cytokine 1 93.44 High High
mu opioid receptor 1 91.04 High High
analgesia 1 88.16 High High
Opioid 1 87.32 High High
Disease Link Frequency Relevance Heat
Neuroblastoma 1 63.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, transcription of the mu-opioid receptor gene is induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, which in turn is an activator of AP-1 transcription factors.
TPA Positive_regulation (induced) of Transcription (transcription) of mu-opioid receptor associated with kinase c and opioid receptor
1) Confidence 0.22 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11901219 Disease Relevance 0.06 Pain Relevance 0.61

General Comments

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