INT101721

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 10
Disease Relevance 1.22
Pain Relevance 7.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1) plasma membrane (OPRM1)
signal transducer activity (OPRM1)
Anatomy Link Frequency
B cells 2
melanocytes 2
T cells 2
ovary 2
frontal cortex 2
OPRM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 67 100.00 Very High Very High Very High
opiate 8 100.00 Very High Very High Very High
agonist 3 99.98 Very High Very High Very High
Ventral tegmentum 6 99.68 Very High Very High Very High
Cannabinoid receptor 6 99.66 Very High Very High Very High
cytokine 2 99.54 Very High Very High Very High
withdrawal 22 99.12 Very High Very High Very High
Opioid 14 99.00 Very High Very High Very High
adenocard 1 98.92 Very High Very High Very High
cocaine 4 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 5 99.84 Very High Very High Very High
Cancer 5 99.66 Very High Very High Very High
Urological Neuroanatomy 2 99.16 Very High Very High Very High
Inflammatory Pain 1 91.60 High High
INFLAMMATION 2 88.84 High High
Drug Dependence 2 77.96 Quite High
Pain 1 73.60 Quite High
Neuroblastoma 1 58.72 Quite High
Recurrence 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, transcription of the mu-opioid receptor gene is induced by the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C, which in turn is an activator of AP-1 transcription factors.
Positive_regulation (induced) of Transcription (transcription) of mu-opioid receptor associated with kinase c and opioid receptor
1) Confidence 0.48 Published 2002 Journal Mol. Pharmacol. Section Abstract Doc Link 11901219 Disease Relevance 0.06 Pain Relevance 0.60
Transfection into Chinese hamster ovary cells of a cDNA representing only the coding region of OPRM1, carrying adenosine, guanosine, cytidine, and thymidine in position 118, resulted in 1.5-fold lower mRNA levels only for OPRM1-G118, and more than 10-fold lower OPRM1 protein levels, measured by Western blotting and receptor binding assay.
Positive_regulation (resulted) of Transcription (levels) of OPRM1-G118 in ovary associated with adenocard
2) Confidence 0.41 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 16046395 Disease Relevance 0.15 Pain Relevance 0.37
We report that activation of the peripheral cannabinoid receptor type 2 leads to a de novo induction of mu-opioid receptor transcription in Jurkat E6.1 cells.
Positive_regulation (induction) of Transcription (transcription) of mu-opioid receptor associated with cannabinoid receptor and opioid receptor
3) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.73
Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells.
Positive_regulation (induce) of Transcription (transcription) of mu-opioid receptor in T cells associated with cannabinoid receptor, agonist and opioid receptor
4) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Title Doc Link 16434616 Disease Relevance 0 Pain Relevance 0.77
In addition, STAT6 induces expression of the transcription factor GATA3, which also contributes to mu-opioid receptor gene transcription.
Positive_regulation (contributes) of Transcription (transcription) of mu-opioid receptor associated with opioid receptor
5) Confidence 0.41 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16434616 Disease Relevance 0 Pain Relevance 1.03
This study demonstrated the expression of mu-opiate receptor mRNA in cultured epidermal melanocytes, as well as mRNA for pro-opiomelanocortin.
Positive_regulation (demonstrated) of Transcription (expression) of mu-opiate receptor in melanocytes associated with opiate
6) Confidence 0.39 Published 2003 Journal J. Invest. Dermatol. Section Abstract Doc Link 12787137 Disease Relevance 0 Pain Relevance 0.57
An increase in mu-opioid receptor (MOP) mRNA levels was observed in the frontal cortex of 3-h withdrawn rats.
Positive_regulation (increase) of Transcription (levels) of MOP in frontal cortex associated with urological neuroanatomy and opioid receptor
7) Confidence 0.38 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15950784 Disease Relevance 0.17 Pain Relevance 0.53
Herein, we report that in primary human T lymphocytes, Raji B cells, U937 monocytes, primary human polymorphonuclear leukocytes, and mature dendritic cells, the proinflammatory cytokine tumor necrosis factor induced mu-opioid receptor gene transcription.
Positive_regulation (induced) of Transcription (transcription) of mu-opioid receptor gene in B cells associated with necrosis, cancer, opioid receptor and cytokine
8) Confidence 0.34 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 14500744 Disease Relevance 0.84 Pain Relevance 0.50
However, whereas DOR mRNA returned to control levels, MOR mRNA levels remained elevated in animals expressing behavioral sensitization after 14 days of withdrawal.
Positive_regulation (elevated) of Transcription (levels) of MOR associated with opioid receptor and withdrawal
9) Confidence 0.01 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629526 Disease Relevance 0 Pain Relevance 1.30
Conversely, DOR and MOR mRNA levels were elevated in the VTA of animals expressing behavioral sensitization after 2 days of withdrawal.
Positive_regulation (elevated) of Transcription (levels) of MOR associated with ventral tegmentum, opioid receptor and withdrawal
10) Confidence 0.01 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12629526 Disease Relevance 0 Pain Relevance 1.34

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