INT10173

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 45
Total Number 47
Disease Relevance 35.60
Pain Relevance 14.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tnf) extracellular space (Tnf) extracellular region (Tnf)
plasma membrane (Tnf) intracellular (Tnf) extracellular matrix organization (Tnf)
Anatomy Link Frequency
plasma 2
sciatic nerve 2
spinal nerve 1
liver 1
brain 1
Tnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 297 100.00 Very High Very High Very High
cytokine 264 100.00 Very High Very High Very High
Sciatic nerve 42 100.00 Very High Very High Very High
Spinal nerve ligature 25 100.00 Very High Very High Very High
Etanercept 25 99.76 Very High Very High Very High
psoriasis 45 99.74 Very High Very High Very High
Pain 81 99.48 Very High Very High Very High
Neuritis 7 99.46 Very High Very High Very High
Angina 21 99.00 Very High Very High Very High
COX2 58 98.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 378 100.00 Very High Very High Very High
Cancer 180 100.00 Very High Very High Very High
Necrosis 78 100.00 Very High Very High Very High
Nervous System Injury 51 100.00 Very High Very High Very High
Death 33 100.00 Very High Very High Very High
Immunization 1 100.00 Very High Very High Very High
Hypothermia 139 99.92 Very High Very High Very High
Psoriasis 51 99.74 Very High Very High Very High
Neuropathic Pain 207 99.48 Very High Very High Very High
Experimental Autoimmune Neuritis 6 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the interactions between TNFalpha and anesthetics have not been elucidated yet.
TNFalpha Binding (interactions) of
1) Confidence 0.48 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12351275 Disease Relevance 0.44 Pain Relevance 0.69
The binding of death ligands, such as Fas ligand or TNF-?
TNF Binding (binding) of associated with death
2) Confidence 0.47 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291307 Disease Relevance 0.92 Pain Relevance 0
Both drugs have been designed to bind with TNF-?
TNF Binding (bind) of
3) Confidence 0.47 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2274991 Disease Relevance 0.94 Pain Relevance 0.55
To test involvement of tumor necrosis factor-alpha (TNF-alpha), a third group received autologous NP plus local soluble TNF-alpha receptor type 1 (0.013 microg) which binds TNF-alpha to prevent its action.
TNF-alpha Binding (binds) of associated with necrosis and cancer
4) Confidence 0.44 Published 2004 Journal Pain Section Abstract Doc Link 15288398 Disease Relevance 1.04 Pain Relevance 0.51
Tumor necrosis factor alpha (TNF) injected into the sciatic nerve and neutralizing antibodies to its receptor injected around the nerve are respectively associated with inducing and blocking pain behavior beginning 1 to 3 days post-injection.
Tumor necrosis factor alpha Binding (associated) of in sciatic nerve associated with pain, necrosis, cancer and sciatic nerve
5) Confidence 0.38 Published 2000 Journal J. Peripher. Nerv. Syst. Section Abstract Doc Link 10905468 Disease Relevance 0.37 Pain Relevance 0.27
Focal liver necrosis, which had been observed in earlier studies after antigen therapy in AT-EAN, was prevented by passive immunization with neutralizing anti-TNF-alpha antibody.
TNF-alpha Binding (immunization) of in liver associated with immunization, hepatotoxicity and neuritis
6) Confidence 0.36 Published 2000 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 10888366 Disease Relevance 1.43 Pain Relevance 0.67
Interestingly, intra-hippocampal TNF-?
TNF Binding (intra) of
7) Confidence 0.36 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695223 Disease Relevance 0.91 Pain Relevance 0.37
To accomplish this, we determined protein leakage, tumor necrosis factor-alpha (TNF-?)
TNF Spec (determined) Binding (leakage) of associated with necrosis and cancer
8) Confidence 0.36 Published 2008 Journal Clinics Section Body Doc Link PMC2664181 Disease Relevance 0.68 Pain Relevance 0.07
Two reports on the combination of TNF-?
TNF Binding (combination) of
9) Confidence 0.36 Published 2007 Journal Curr Treat Options Oncol Section Body Doc Link PMC2781100 Disease Relevance 0.91 Pain Relevance 0
The primers used were: Adiponectin, 5' GAAGTAGACTCTGCTGAGATGG-3' (sense) and 5' TATCAGTGTAGGAGGTCTGTGATG-3' (antisense); TNF-?
TNF Binding (were) of
10) Confidence 0.36 Published 2008 Journal Lipids Health Dis Section Body Doc Link PMC2613381 Disease Relevance 0.15 Pain Relevance 0
Table 1 summarizes all literature reports on TNF-?
TNF Binding (summarizes) of
11) Confidence 0.36 Published 2007 Journal Curr Treat Options Oncol Section Body Doc Link PMC2781100 Disease Relevance 1.27 Pain Relevance 0
Significantly greater improvement of the levels of inflammatory biomarkers, such as C-reactive protein (CRP), vascular endotherial growth factor (VEGF), and tumor necrosis factor alpha (TNF-?)
TNF Binding (biomarkers) of associated with necrosis, inflammation and cancer
12) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2788597 Disease Relevance 0.71 Pain Relevance 0.05
For example, in cardiac surgery, moderate hypothermia is associated with decreased TNF-?
TNF Binding (associated) of associated with hypothermia
13) Confidence 0.36 Published 2009 Journal Scand J Trauma Resusc Emerg Med Section Body Doc Link PMC2806855 Disease Relevance 2.05 Pain Relevance 0.25
Samples were subsequently thawed immediately before analyses and assayed in duplicate for circulating concentrations of TNF-?
TNF Binding (concentrations) of
14) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819256 Disease Relevance 0.15 Pain Relevance 0.04
mediated signaling by TNF-?
TNF Binding (signaling) of
15) Confidence 0.36 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3003209 Disease Relevance 0.52 Pain Relevance 0.05
Our findings suggest that OSA is closely associated with IL-6 production in IGM, whereas in the absence of IGM, it is associated with TNF-?.
TNF Binding (associated) of associated with apnoea
16) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 1.68 Pain Relevance 0.13
In a multivariate linear regression analysis in the control group, the LowSaO2 was associated with TNF-?
TNF Binding (associated) of
17) Confidence 0.36 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3002325 Disease Relevance 0.25 Pain Relevance 0.04
B can bind with high affinity to the promoter regions of pro-inflammatory genes such as tumor necrosis factor alpha (TNF-?)
TNF Binding (bind) of associated with necrosis, inflammation and cancer
18) Confidence 0.36 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2898548 Disease Relevance 0.96 Pain Relevance 0.22
We report that there is a p38-dependent TNF-?
TNF Binding (is) of
19) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 1.13 Pain Relevance 0.60
SB203580 treatment significantly reduced the immunoreactivity of iNOS, TNF-?
TNF Binding (immunoreactivity) of
20) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2881061 Disease Relevance 0.22 Pain Relevance 0.41

General Comments

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