INT101739

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Context Info
Confidence 0.25
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.43
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (CACNA1E) small molecule metabolic process (CACNA1E) plasma membrane (CACNA1E)
transmembrane transport (CACNA1E)
Anatomy Link Frequency
embryonic kidney 1
CACNA1E (Homo sapiens)
Pain Link Frequency Relevance Heat
Mexiletine 6 98.86 Very High Very High Very High
sodium channel 2 93.36 High High
lidocaine 1 92.32 High High
local anesthetic 2 91.28 High High
Inflammation 6 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Takayasu Arteritis 50 99.52 Very High Very High Very High
Autoimmune Disease 32 77.28 Quite High
Syndrome 12 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low
Microscopic Polyangiitis 6 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 6 5.00 Very Low Very Low Very Low
Fever Of Unknown Origin 5 5.00 Very Low Very Low Very Low
Vasculitis 4 5.00 Very Low Very Low Very Low
Systemic Lupus Erythematosus 4 5.00 Very Low Very Low Very Low
Idiopathic Thrombocytopenic Purpura 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FigureĀ 5.Expression profiles of DEFA3 (A), IL-4 (Bi) and IL-10 (Bii) in the 13 TA patients.
Gene_expression (5.Expression) of Bii associated with takayasu arteritis
1) Confidence 0.25 Published 2010 Journal DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes Section Body Doc Link PMC2993541 Disease Relevance 0.43 Pain Relevance 0
To examine if this is also true for mexiletine, we have systematically measured mexiletine sensitivity of the Na channel isoforms, rH1, (mu)1, and rBII, which were transiently expressed in human embryonic kidney (HEK) 293 cells.
Gene_expression (expressed) of rBII in embryonic kidney associated with mexiletine
2) Confidence 0.09 Published 2002 Journal FEBS Lett. Section Abstract Doc Link 11904157 Disease Relevance 0 Pain Relevance 0.49

General Comments

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