INT10175

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Context Info
Confidence 0.69
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 6.13
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ns5atp9) nucleus (Ns5atp9)
Anatomy Link Frequency
platelet 4
blood 1
brain 1
cleavage 1
Ns5atp9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 2 100.00 Very High Very High Very High
antagonist 64 99.68 Very High Very High Very High
bradykinin 1 96.66 Very High Very High Very High
Inflammation 72 96.32 Very High Very High Very High
cytokine 10 95.68 Very High Very High Very High
Neurotransmitter 1 94.32 High High
Pain 6 93.20 High High
Nicotine 28 90.20 High High
Inflammatory response 5 84.44 Quite High
tetrodotoxin 1 83.36 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 4 99.98 Very High Very High Very High
Pleurisy 7 99.12 Very High Very High Very High
Neurodegenerative Disease 10 98.52 Very High Very High Very High
Thrombosis 2 97.36 Very High Very High Very High
Nicotine Addiction 2 97.24 Very High Very High Very High
Disease 48 97.12 Very High Very High Very High
INFLAMMATION 80 96.32 Very High Very High Very High
Pain 3 93.20 High High
Leukopenia 1 93.16 High High
Nociception 2 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cotinine possibly increases the turnover rate of platelet-activating factor (PAF) because it is a potent activator of PAF hydrolase, and it may play a significant role in tobacco-induced arterial thrombosis.
Positive_regulation (activator) of PAF in platelet associated with thrombosis
1) Confidence 0.69 Published 1995 Journal Pharmacology Section Abstract Doc Link 7716176 Disease Relevance 0.19 Pain Relevance 0.34
Cotinine possibly increases the turnover rate of platelet-activating factor (PAF) because it is a potent activator of PAF hydrolase, and it may play a significant role in tobacco-induced arterial thrombosis.
Positive_regulation (activating) of PAF in platelet associated with thrombosis
2) Confidence 0.69 Published 1995 Journal Pharmacology Section Abstract Doc Link 7716176 Disease Relevance 0.19 Pain Relevance 0.33
The PAF levels were elevated at 24 and 28 h, presenting a remarkable peak at 32 h post-treatment.
Positive_regulation (elevated) of PAF
3) Confidence 0.65 Published 2005 Journal Arch. Toxicol. Section Abstract Doc Link 15995853 Disease Relevance 0.74 Pain Relevance 0.44
To investigate the interaction between PAF, TNF-alpha and myocardial depressant factor, the blood levels of these three mediators were evaluated: shocked rats exhibited increased PAF levels with a peak at 30 min.
Positive_regulation (increased) of PAF in blood
4) Confidence 0.64 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1468489 Disease Relevance 0.69 Pain Relevance 0.03
CONCLUSIONS: These findings suggest a role for endogenous PAF in nociceptive transmission, especially for persistent pain such as that which occurs in the late phase of the formalin test.
Positive_regulation (role) of PAF
5) Confidence 0.50 Published 2002 Journal Psychopharmacology (Berl.) Section Body Doc Link 12373444 Disease Relevance 0 Pain Relevance 0
The hyperalgesic response to PAF was specifically inhibited by agents that interfere with the lipoxygenase pathway of arachidonic acid metabolism and was not affected by cyclooxygenase inhibitors.
Positive_regulation (response) of PAF associated with hyperalgesia
6) Confidence 0.48 Published 1987 Journal Biochem. Pharmacol. Section Abstract Doc Link 2822047 Disease Relevance 0.53 Pain Relevance 0.42
Figure 2 shows the influence of the cys-LT1 receptor antagonist montelukast on PAF induced tracheal secretory activity.
Positive_regulation (induced) of PAF associated with antagonist
7) Confidence 0.45 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2278150 Disease Relevance 0 Pain Relevance 0.15
In contrast, accumulating evidence supports the notion that the pulmonary effects of PAF could be mediated by the secondary release of leukotrienes [18].
Positive_regulation (mediated) of PAF
8) Confidence 0.45 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2278150 Disease Relevance 0.53 Pain Relevance 0.20
PAF originates from cleavage of membrane phospholipids by phospholipase A2 yielding lyso-PAF, which is further acetylated to form biologically active PAF.
Positive_regulation (acetylated) of PAF in cleavage
9) Confidence 0.45 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2278150 Disease Relevance 0.55 Pain Relevance 0.37
Platelet-activating factor (PAF) is a potent endogenous phospholipid modulator of diverse biological activities, including inflammation.
Positive_regulation (activating) of PAF in Platelet associated with inflammation
10) Confidence 0.42 Published 2007 Journal Dig. Dis. Sci. Section Abstract Doc Link 17410443 Disease Relevance 0.29 Pain Relevance 0.33
These responses to PAF occurred only when experiments were conducted at or before approximately 9 A.M.
Positive_regulation (responses) of PAF
11) Confidence 0.35 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2597284 Disease Relevance 0 Pain Relevance 0.20
These findings suggest that endotoxin-induced acute inhibition of neurally-mediated acid responses, stimulated by gastric distension or administration of 2-deoxy-D-glucose, do not involve the activation of endogenous opioids or PAF receptors.
Positive_regulation (activation) of PAF associated with endogenous opioid
12) Confidence 0.26 Published 1997 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 9466350 Disease Relevance 0 Pain Relevance 0.32
However, mediators detected in the exudates of such pleurisies were different; in carrageenin-induced pleurisy bradykinin and prostacyclin (PGI2) caused exudate formation, while zymosan-induced pleurisy showed early degradation of mast cells and activation of complements, followed by an increase in platelet activating factor (PAF).
Positive_regulation (increase) of PAF in platelet associated with pleurisy and bradykinin
13) Confidence 0.25 Published 2000 Journal Yakugaku Zasshi Section Abstract Doc Link 10825809 Disease Relevance 1.33 Pain Relevance 0.58
However, increased concentrations of PAF in the brain are also implicated in neurodegenerative diseases such as AD [69,70].
Positive_regulation (increased) of PAF in brain associated with disease and neurodegenerative disease
14) Confidence 0.08 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2820992 Disease Relevance 0.88 Pain Relevance 0.46
The histograms, in Figure 4A, show the increase in fluorescence intensity over the control responses upon the addition of PAF, as well as the inhibitory effect of feG on PAF enhancement of CD11b antibody binding.
Positive_regulation (enhancement) of PAF
15) Confidence 0.05 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0.19 Pain Relevance 0
The effects of the peptides on the binding of antibodies to cell surface molecules were evaluated by determining the changes in mean fluorescence intensity (MFI) of cells incubated in the presence of peptide and PAF and those incubated in the presence of PAF alone, after subtracting the background (Control; MFI expressed in cells incubated in absence of PAF and peptide).


Positive_regulation (presence) of PAF
16) Confidence 0.05 Published 2003 Journal BMC Immunol Section Body Doc Link PMC152650 Disease Relevance 0 Pain Relevance 0.03

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