INT101779

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.57
Pain Relevance 3.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Camk2a) kinase activity (Camk2a)
Camk2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 18 99.74 Very High Very High Very High
Dopamine 31 99.40 Very High Very High Very High
Intracerebroventricular 3 98.74 Very High Very High Very High
Inflammation 7 94.60 High High
dorsal root ganglion 21 92.80 High High
Dynorphin 3 88.80 High High
substance P 5 87.68 High High
qutenza 1 87.36 High High
Kinase C 5 82.64 Quite High
Spinal cord 1 78.00 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 6 95.24 Very High Very High Very High
INFLAMMATION 7 94.60 High High
Ganglion Cysts 22 92.80 High High
Eating Disorder 3 89.80 High High
Nociception 9 83.08 Quite High
Targeted Disruption 1 54.60 Quite High
Pain 3 19.04 Low Low
Neuropathic Pain 8 5.00 Very Low Very Low Very Low
Hyperalgesia 7 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The regulation of the DAT in the PC12 cell model was dependent upon activation of Ca(2+)/calmodulin-dependent kinase II.
Positive_regulation (dependent) of Positive_regulation (activation) of calmodulin-dependent kinase II
1) Confidence 0.31 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11907188 Disease Relevance 0 Pain Relevance 0.30
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (enhanced) of Positive_regulation (activation) of CaM kinase II associated with dopamine, agonist and intracerebroventricular
2) Confidence 0.24 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.71
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (increased) of Positive_regulation (activation) of CaM kinase II associated with dopamine, agonist and intracerebroventricular
3) Confidence 0.24 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.70
Recently, it has been shown that intracerebroventricular (i.c.v.) injection of the D-1 DA receptor agonist, SKF-82958, produces an enhanced locomotor-activating effect as well as increased activation of striatal ERK 1/2 MAP kinase, CaM kinase II, CREB, and c-fos in food-restricted (FR) relative to ad libitum fed (AL) rats.
Positive_regulation (produces) of Positive_regulation (activation) of CaM kinase II associated with dopamine, agonist and intracerebroventricular
4) Confidence 0.24 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 16257473 Disease Relevance 0.09 Pain Relevance 0.71
The mechanisms responsible for the increase include upregulation of P2X3 receptors [11], enhancement of trafficking of P2X3 receptors toward the membrane [31] and activation of calmodulin protein kinase II [34].
Positive_regulation (enhancement) of Positive_regulation (activation) of calmodulin protein kinase II
5) Confidence 0.10 Published 2007 Journal Mol Pain Section Body Doc Link PMC2063498 Disease Relevance 1.30 Pain Relevance 0.60

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