INT10179

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Context Info
Confidence 0.48
First Reported 1983
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.54
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fpr1) plasma membrane (Fpr1) signal transducer activity (Fpr1)
Anatomy Link Frequency
plasma 2
Fpr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 4 95.96 Very High Very High Very High
Analgesic 7 75.00 Quite High
Morphine 2 73.36 Quite High
analgesia 4 72.64 Quite High
tail-flick 1 70.80 Quite High
Intracerebroventricular 1 54.08 Quite High
narcan 2 38.16 Quite Low
Opioid 1 35.52 Quite Low
Inflammation 13 27.60 Quite Low
Pain 1 26.08 Quite Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 120 95.76 Very High Very High Very High
Repression 1 84.32 Quite High
Cancer 52 81.36 Quite High
INFLAMMATION 23 27.60 Quite Low
Stomach Cancer 2 10.76 Low Low
Pancreatitis 6 5.00 Very Low Very Low Very Low
Carcinoma 4 5.00 Very Low Very Low Very Low
Mycobacterial Infection 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gpr109b/PUMA-G, Fpr1, Ccrl2 and Ednrb) ([12-16], Sweet et al, unpublished data), regulated expression of others has not been widely studied.
Gene_expression (expression) of Fpr1
1) Confidence 0.48 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.08 Pain Relevance 0
Four analogues of Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2, a mammalian FMRFamide-like peptide with antiopiate properties, were synthesized with N-terminus modifications and were shown to have high affinity for F8Famide binding sites.
Gene_expression (synthesized) of Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2
2) Confidence 0.34 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1468500 Disease Relevance 0 Pain Relevance 0.39
New carboxyalkyl compounds derived from Phe-Leu and Phe-Ala were synthesized and checked as inhibitors of "enkephalinase", a metalloendopeptidase cleaving the Gly3-Phe4 bond of enkephalins from mouse striatal membranes.
Gene_expression (synthesized) of Phe-Leu associated with enkephalin
3) Confidence 0.03 Published 1983 Journal J. Med. Chem. Section Abstract Doc Link 6298420 Disease Relevance 0 Pain Relevance 0.27
The plasma membrane expression of EGFR (p = 0.02) and MET receptor (p < 0.0001) and the cytoplasmic proteins ADAM9 (p < 0.001), SRC (p < 0.0001), PKB?
Gene_expression (expression) of MET receptor in plasma
4) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0.46 Pain Relevance 0
EGFR and MET receptor were scored for their plasma membrane staining only.


Gene_expression (scored) of MET receptor in plasma
5) Confidence 0.01 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2270852 Disease Relevance 0 Pain Relevance 0

General Comments

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