INT101813

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.63
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (KEAP1, NFE2L2) cytoplasm (KEAP1, NFE2L2) cytosol (NFE2L2)
endoplasmic reticulum (KEAP1) nucleolus (KEAP1) plasma membrane (NFE2L2)
Anatomy Link Frequency
lung 1
KEAP1 (Homo sapiens)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
tolerance 3 90.08 High High
cINOD 3 65.12 Quite High
antidepressant 1 63.12 Quite High
anticonvulsant 1 60.44 Quite High
Mechanosensation 1 46.44 Quite Low
Inflammation 4 38.08 Quite Low
Acute pain 1 36.96 Quite Low
Glutamate 1 25.52 Quite Low
sSRI 3 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 31 100.00 Very High Very High Very High
Lung Cancer 54 84.56 Quite High
Cancer 107 84.08 Quite High
Adenocarcinoma 7 82.76 Quite High
Heat Stress Disorders 1 79.36 Quite High
Lifespan 16 75.36 Quite High
Apoptosis 3 60.40 Quite High
INFLAMMATION 4 53.72 Quite High
Neurogenic Inflammation 1 38.08 Quite Low
Pain 1 36.96 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KEAP1 constitutively suppresses NRF2 activity in the absence of stress; however, oxidants, xenobiotics, and electrophiles hamper the KEAP1-mediated proteasomal degradation of NRF2, which results in increased nuclear accumulation and, in turn, the transcriptional induction of target genes that ensure cell survival. [7,23] Recently, Padmanabhan et al. [24] reported a heterozygous somatic mutation (G430C) in KEAP1 in one lung cancer tumor and a G364C mutation in an adenocarcinoma and a small cell lung cancer cell line.
KEAP1 Negative_regulation (suppresses) of NRF2 in lung associated with adenocarcinoma, stress, lung cancer and cancer
1) Confidence 0.47 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.66 Pain Relevance 0
Immunoprecipitation studies showed that indomethacin treatment also inhibited Nrf2 tethering to KIAA0132 (the human homolog of Keap1 accession #D50922), which is believed to be a negative regulator of Nrf2.
KIAA0132 Negative_regulation (regulator) of Nrf2
2) Confidence 0.39 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.05 Pain Relevance 0.17
Without such stresses, Nrf2 is normally repressed by the oxidative stress sensor Keap1 [38], which binds and degrades Nrf2 through the ubiquitin-proteasome system.
Keap1 Negative_regulation (repressed) of Nrf2 associated with stress
3) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822842 Disease Relevance 0.92 Pain Relevance 0.11

General Comments

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