INT101816

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Context Info
Confidence 0.77
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 6.91
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
Anatomy Link Frequency
nucleus 1
lung 1
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.56 Very High Very High Very High
antagonist 2 98.76 Very High Very High Very High
cINOD 21 97.36 Very High Very High Very High
Analgesic 1 84.92 Quite High
tolerance 3 83.04 Quite High
Inflammation 19 75.00 Quite High
Pain 2 64.96 Quite High
Glutamate 7 58.96 Quite High
antidepressant 1 56.08 Quite High
anticonvulsant 1 53.40 Quite High
Disease Link Frequency Relevance Heat
Stress 82 99.74 Very High Very High Very High
Lung Cancer 328 99.52 Very High Very High Very High
Cancer 652 99.24 Very High Very High Very High
Non-small-cell Lung Cancer 144 97.20 Very High Very High Very High
Malignant Neoplastic Disease 24 96.44 Very High Very High Very High
Apoptosis 54 93.84 High High
Adenocarcinoma 44 93.72 High High
Targeted Disruption 13 91.72 High High
Microsatellite Instability 6 81.72 Quite High
Toxicity 35 78.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results also support the hypothesis that indomethacin-induced transcriptional activation of GCLC involves the redox-dependent release of KIAA0132 from Nrf2 followed by the nuclear translocation of Nrf2.
Localization (translocation) of Nrf2
1) Confidence 0.77 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.09
Finally, simultaneous treatment with NAC inhibited both indomethacin-induced release of Nrf2 from KIAA0132 and indomethacin-induced nuclear translocation of Nrf2.
Localization (translocation) of Nrf2
2) Confidence 0.77 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.10
Indirect immunofluorescence using intact cells demonstrated that indomethacin induced the nuclear translocation of Nrf2, a transcription factor believed to regulate GCLC expression.
Localization (translocation) of Nrf2
3) Confidence 0.77 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.06 Pain Relevance 0.12
To study the localization of NRF2 in primary lung tumors, we performed immunohistochemistry on primary lung tumor tissues using anti-NRF2 antibody.
Localization (localization) of NRF2 in lung associated with lung cancer
4) Confidence 0.76 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.31 Pain Relevance 0
To determine whether KEAP1 mutations correlated with NRF2 activation, we performed immunoblot analysis to examine the nuclear accumulation of NRF2.
Spec (examine) Localization (accumulation) of NRF2
5) Confidence 0.76 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.80 Pain Relevance 0
Cancer cells demonstrated increased nuclear localization of NRF2 in comparison with normal cells (Figures 4A–4C and S4).
Localization (localization) of NRF2 associated with cancer
6) Confidence 0.76 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.82 Pain Relevance 0
The PCR condition, as well as Taqman probes and primers for Nrf2, NQO1, heme oxygenase-1 (HO-1), and GAPDH were reported previously (Wang et al. 2007).
Localization (reported) of Nrf2
7) Confidence 0.75 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0 Pain Relevance 0
Upon induction, Nrf2 is stabilized because of impaired Keap1-E3 ubiquitin ligase activity, which results in activation of the Nrf2 signaling pathway (Cullinan et al. 2004; Furukawa and Xiong 2005; Kobayashi et al. 2004; Sun et al. 2007; Zhang et al. 2004b).
Localization (stabilized) of Nrf2
8) Confidence 0.75 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0 Pain Relevance 0
These results also support the hypothesis that indomethacin-induced transcriptional activation of GCLC involves the redox-dependent release of KIAA0132 from Nrf2 followed by the nuclear translocation of Nrf2.
Localization (release) of Nrf2
9) Confidence 0.72 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.09
These results also support the hypothesis that indomethacin-induced transcriptional activation of GCLC involves the redox-dependent release of KIAA0132 from Nrf2 followed by the nuclear translocation of Nrf2.
Localization (translocation) of Nrf2
10) Confidence 0.72 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.09
Phosphorylation of NRF2 by protein kinase(s) associated with the MAPK/ERK signaling cascade increases stabilization of NRF2 and has been proposed as an important mechanism leading to increased expression of ARE-dependent genes [11].
Localization (stabilization) of NRF2
11) Confidence 0.71 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.42 Pain Relevance 0.06
Finally, simultaneous treatment with NAC inhibited both indomethacin-induced release of Nrf2 from KIAA0132 and indomethacin-induced nuclear translocation of Nrf2.
Localization (release) of Nrf2
12) Confidence 0.67 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.09
In the absence of functional KEAP1 activity, cancer cells demonstrated an increased nuclear accumulation of NRF2 as well as an increase in total NRF2.
Localization (accumulation) of NRF2 associated with cancer
13) Confidence 0.67 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 1.08 Pain Relevance 0
Cancer cells demonstrated increased nuclear localization of NRF2 in comparison with normal cells (Figures 4A–4C and S4).
Localization (localization) of NRF2 associated with cancer
14) Confidence 0.67 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.82 Pain Relevance 0
Rather, this action of celecoxib involved generation of mitochondria-derived reactive oxygen species, Akt phosphorylation, and nuclear translocation of the transcription factor Nrf2, with N-acetylcysteine, PI-3K antagonist LY290042, and dominant-negative Akt abrogating the effects.
Localization (translocation) of Nrf2 associated with antagonist
15) Confidence 0.64 Published 2010 Journal Free Radic. Biol. Med. Section Abstract Doc Link 20083195 Disease Relevance 0.34 Pain Relevance 0.43
Nrf2 stabilization was induced by exposure of cells to 50 ?
Localization (stabilization) of Nrf2
16) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.08 Pain Relevance 0
Similarly, it has also been shown that acetaminophen can initiate nuclear translocation of Nrf2 in vivo in mice (45) and that it is then functionally active.
Localization (translocation) of Nrf2 associated with paracetamol
17) Confidence 0.21 Published 2010 Journal Carcinogenesis Section Body Doc Link PMC2802674 Disease Relevance 0.24 Pain Relevance 0.52
Under oxidative stress conditions, Nrf2 is released from Keap1 into the nucleus where it induces the expression of phase II enzymes [38].
Localization (released) of Nrf2 in nucleus associated with stress
18) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822842 Disease Relevance 0.93 Pain Relevance 0.10

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