INT101819

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.47
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCLC) small molecule metabolic process (GCLC) cellular nitrogen compound metabolic process (GCLC)
ligase activity (GCLC) cytoplasm (GCLC)
GCLC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 90.60 High High
corticosteroid 38 65.08 Quite High
antagonist 8 50.00 Quite Low
Inflammation 13 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
Onset of action 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 189 99.14 Very High Very High Very High
Recurrence 10 99.00 Very High Very High Very High
Asthma 78 53.84 Quite High
Eosinophilia 11 51.28 Quite High
Neuropathy 5 49.12 Quite Low
Paranasal Sinus Disease 2 40.96 Quite Low
Sinusitis 3 38.32 Quite Low
Rhinitis 9 37.28 Quite Low
Increased Venous Pressure Under Development 23 32.80 Quite Low
Fever 3 25.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results also support the hypothesis that indomethacin-induced transcriptional activation of GCLC involves the redox-dependent release of KIAA0132 from Nrf2 followed by the nuclear translocation of Nrf2.
Positive_regulation (induced) of Positive_regulation (activation) of GCLC
1) Confidence 0.59 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.09
One patient had a relapse of CSS within 1 week of starting montelukast and required an increase in the GCS and cyclophosphamide doses (Solans et al 2002), while the other patient did not have any increase in symptoms even after 1 year of montelukast therapy (Kalyoncu et al 2001).
Positive_regulation (required) of Positive_regulation (increase) of GCS associated with syndrome and recurrence
2) Confidence 0.01 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661620 Disease Relevance 1.47 Pain Relevance 0.06

General Comments

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