INT10182

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.55
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 27
Disease Relevance 7.82
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T lymphocyte 4
neuronal 1
epithelial cells 1
synapse 1
reservoir 1
HTLVR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 5 99.36 Very High Very High Very High
Dopamine 176 96.36 Very High Very High Very High
adenocard 110 95.28 Very High Very High Very High
methadone 2 92.56 High High
Spinal cord 24 89.04 High High
medulla 22 87.44 High High
Inflammation 48 78.08 Quite High
Catecholamine 44 70.24 Quite High
opiate 1 70.24 Quite High
Neurotransmitter 44 67.12 Quite High
Disease Link Frequency Relevance Heat
Infection 191 100.00 Very High Very High Very High
Hiv Type 2 Infection Or Seropositivity 2 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 62 99.98 Very High Very High Very High
Neurological Disease 22 99.24 Very High Very High Very High
Malignant Neoplastic Disease 44 99.00 Very High Very High Very High
Htlv Types I And Ii 176 97.32 Very High Very High Very High
Leukemia 47 97.12 Very High Very High Very High
Death 22 96.36 Very High Very High Very High
Viral Infection 22 95.64 Very High Very High Very High
Demyelinating Disease 22 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, no coinfection HIV1/HTLV1 and no HIV2 infection were detected.
Gene_expression (detected) of HTLV1 associated with acquired immune deficiency syndrome or hiv infection, hiv type 2 infection or seropositivity and infection
1) Confidence 0.55 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1468865 Disease Relevance 0.56 Pain Relevance 0.09
Since all HTLV seropositives were born in Middle Eastern countries, did not travel outside Israel and were not infected by HIV1 or by HTLV type 2, it is possible that the source of HTLV1 infection in that group was in an endemic reservoir of HTLV1 in Israel.
Gene_expression (source) of HTLV1 in reservoir associated with acquired immune deficiency syndrome or hiv infection and infection
2) Confidence 0.43 Published 1992 Journal Int J Epidemiol Section Abstract Doc Link 1468865 Disease Relevance 0.55 Pain Relevance 0.08
We have found that in an in vitro coinfection system (HIV-1 + HTLV-I), morphine treatment further enhanced the levels of HTLV-I p19.
Gene_expression (levels) of HTLV-I p19 associated with acquired immune deficiency syndrome or hiv infection and morphine
3) Confidence 0.30 Published 1999 Journal DNA Cell Biol. Section Abstract Doc Link 10235111 Disease Relevance 1.65 Pain Relevance 0.48
These results indicate that the lipid metabolism pathway as well as the creatine and polyamine biosynthesis pathways are commonly deregulated after expression of HTLV3 and Tax3, indicating that the noted changes are likely due to Tax3 expression.
Gene_expression (expression) of HTLV3
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.04
These results indicate that the lipid metabolism pathway as well as the creatine and polyamine biosynthesis pathways are commonly deregulated after expression of HTLV3 and Tax3, indicating that the noted changes are likely due to Tax3 expression.
Gene_expression (expression) of HTLV3
5) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.76 Pain Relevance 0
Glutathione was downregulated in HTLV3 transfected cells as well as HTLV1 transformed cells, indicating that downregulation of glutathione is a consequence of viral infection, not necessarily the transformation process.
Gene_expression (transfected) of HTLV3 associated with viral infection
6) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.22 Pain Relevance 0.06
This reveals that the expression of full length HTLV3 or just Tax3 affects the tightly regulated biosynthesis of polyamines in the cells, thereby causing disturbances in the genetic processes.
Gene_expression (expression) of HTLV3
7) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.08 Pain Relevance 0
HTLV3), expression-specific (Tax1 vs.
Gene_expression (expression) of HTLV3
8) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.03
We used the LAESI technique to identify metabolic changes in HTLV1 and Tax1 transformed T lymphocytes and in HTLV3 and Tax3 transfected kidney epithelial cells.
Gene_expression (transformed) of HTLV1 in epithelial cells
9) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0
These metabolites were not detected in HTLV3 or Tax3 transfected cells, indicating that they were specific to HTLV1 induced transformation.
Neg (not) Gene_expression (transfected) of HTLV3
10) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.06 Pain Relevance 0.13
The non-HTLV transformed T lymphocyte cells (CEM and H9) and kidney epithelial cells (293T) ), the HTLV1 transformed cells (C81 and HUT102), the H9 cells stably transfected with Tax1 of HTLV1 (H9-Tax1) and the 293T cells transfected with HTLV3 (293T-HTLV3) and expressing Tax3 (293T-Tax3) were maintained in RPMI 1640 medium containing fetal bovine serum, L-glutamine (2 mM), penicillin (100 units/ml) and streptomycin (100 µg/ml).
Gene_expression (expressing) of HTLV3 in T lymphocyte
11) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0
The non-HTLV transformed T lymphocyte cells (CEM and H9) and kidney epithelial cells (293T) ), the HTLV1 transformed cells (C81 and HUT102), the H9 cells stably transfected with Tax1 of HTLV1 (H9-Tax1) and the 293T cells transfected with HTLV3 (293T-HTLV3) and expressing Tax3 (293T-Tax3) were maintained in RPMI 1640 medium containing fetal bovine serum, L-glutamine (2 mM), penicillin (100 units/ml) and streptomycin (100 µg/ml).
Gene_expression (transfected) of HTLV3 in T lymphocyte
12) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0
Interestingly, HTLV1 infection can result in the neurological disorder HAM/TSP.
Gene_expression (infection) of HTLV1 associated with neurological disease and infection
13) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.70 Pain Relevance 0.09
Considering their implications in neuronal processes, it would be interesting to determine if they were also deregulated in HAM/TSP patient samples and understanding how changes in their expression relate to this diseased state.

293T vs. 293T-HTLV3 metabolites

Gene_expression (metabolites) of HTLV3 in neuronal
14) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.16 Pain Relevance 0.27
These results suggest that the metabolic changes observed in the HTLV1 transformed cells can, in part, be attributed to Tax1 expression.

293T vs. 293T-HTLV3 and 293T-Tax3 cells

Gene_expression (expression.) of HTLV3
15) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.05
In fact, only two metabolites (spermidine and N-acetyl aspartic acid) were upregulated in both HTLV1 transformed and HTLV3 transfected cells.
Gene_expression (transformed) of HTLV3
16) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0.18
Dramatic changes were observed in the lipid abundances and types between non-HTLV1 transformed and HTLV1 transformed cells (expanded spectra are shown in Figure 6).
Gene_expression (transformed) of HTLV1
17) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.09
Estimates of worldwide HTLV1 infections are currently 15 to 25 million individuals.
Gene_expression (infections) of HTLV1 associated with infection
18) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 1.37 Pain Relevance 0.04
These results suggest that the metabolic changes observed in the HTLV1 transformed cells can, in part, be attributed to Tax1 expression.

293T vs. 293T-HTLV3 and 293T-Tax3 cells

Gene_expression (293T) of HTLV3
19) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0 Pain Relevance 0.05
The non-HTLV transformed T lymphocyte cells (CEM and H9) and kidney epithelial cells (293T) ), the HTLV1 transformed cells (C81 and HUT102), the H9 cells stably transfected with Tax1 of HTLV1 (H9-Tax1) and the 293T cells transfected with HTLV3 (293T-HTLV3) and expressing Tax3 (293T-Tax3) were maintained in RPMI 1640 medium containing fetal bovine serum, L-glutamine (2 mM), penicillin (100 units/ml) and streptomycin (100 µg/ml).
Gene_expression (transfected) of HTLV3 in T lymphocyte
20) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935367 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox