INT101822

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.23

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cytosol (GCLC) small molecule metabolic process (GCLC) cellular nitrogen compound metabolic process (GCLC)
ligase activity (GCLC) cytoplasm (GCLC)
GCLC (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 6 82.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 2 72.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simultaneous incubation with the thiol antioxidant N-acetylcysteine (NAC) inhibited indomethacin-mediated increases in GCLC mRNA, suggesting that increases in GCLC message were triggered by changes in intracellular oxidation/reduction (redox) reactions.
Negative_regulation (inhibited) of Positive_regulation (increases) of GCLC
1) Confidence 0.57 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.07 Pain Relevance 0.15
Consistent with this idea, over-expression of Nrf2 increased GCLC reporter gene expression and over-expression of KIAA0132 inhibited GCLC reporter gene activity as well as inhibited indomethacin-induced increases in the expression of GCLC.
Negative_regulation (inhibited) of Positive_regulation (increases) of GCLC
2) Confidence 0.42 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0 Pain Relevance 0.08

General Comments

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