INT101823

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Context Info
Confidence 0.59
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.15
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
Anatomy Link Frequency
skin 2
A549 2
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 5 83.44 Quite High
metalloproteinase 1 80.60 Quite High
cINOD 3 56.76 Quite High
Inflammation 32 51.12 Quite High
psoriasis 22 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
chemokine 7 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 450 100.00 Very High Very High Very High
Wound Healing 1 99.96 Very High Very High Very High
Targeted Disruption 5 99.84 Very High Very High Very High
Toxicity 61 97.40 Very High Very High Very High
Death 81 94.48 High High
Stress 54 84.88 Quite High
Breast Cancer 16 78.56 Quite High
Apoptosis 81 78.32 Quite High
Lung Cancer 224 67.00 Quite High
Non-small-cell Lung Cancer 96 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of Nrf2 expression in UROtsa cells reverted the MTT curve [i.e., oridonin lost its protection against As(III) toxicity] and aggravated As(III)-induced cell death (Figure 4D, center panel).
Negative_regulation (Inhibition) of Gene_expression (expression) of Nrf2 associated with toxicity and death
1) Confidence 0.59 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.93 Pain Relevance 0
M, Nrf2 protein levels decreased in a dose-dependent manner, whereas the expression of Keap1 and ?
Negative_regulation (decreased) of Gene_expression (levels) of Nrf2 protein
2) Confidence 0.43 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.23 Pain Relevance 0
This decrease in Nrf2 protein level in response to high doses of oridonin is not due solely to cell toxicity because Keap1 or ?
Negative_regulation (decrease) of Gene_expression (level) of Nrf2 protein associated with toxicity
3) Confidence 0.43 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.63 Pain Relevance 0
Immunoblot analysis confirmed the effectiveness of Nrf2-siRNA in reducing Nrf2 expression (Figure 4D, center panel).
Negative_regulation (reducing) of Gene_expression (expression) of Nrf2
4) Confidence 0.43 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.80 Pain Relevance 0
Immunoprecipitation studies showed that indomethacin treatment also inhibited Nrf2 tethering to KIAA0132 (the human homolog of Keap1 accession #D50922), which is believed to be a negative regulator of Nrf2.
Negative_regulation (inhibited) of Gene_expression (tethering) of Nrf2
5) Confidence 0.41 Published 2002 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11909699 Disease Relevance 0.05 Pain Relevance 0.17
Transfection of NRF2 siRNA in cancer cells decreased the NRF2 message by 80% and simultaneously downregulated the expression of NRF2 target genes (Figure 6B).
Negative_regulation (decreased) of Gene_expression (Transfection) of NRF2 associated with cancer
6) Confidence 0.41 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.54 Pain Relevance 0
Critically, the enhanced expression of various antioxidants and detoxification genes was verified to be NRF2-dependent, because siRNA targeted against NRF2 transcript attenuated the expression of these NRF2-dependent genes in A549 cells.
Negative_regulation (attenuated) of Gene_expression (expression) of NRF2 in A549
7) Confidence 0.41 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.76 Pain Relevance 0
Transfection of NRF2 siRNA in cancer cells decreased the NRF2 message by 80% and simultaneously downregulated the expression of NRF2 target genes (Figure 6B).
Negative_regulation (downregulated) of Gene_expression (Transfection) of NRF2 associated with cancer
8) Confidence 0.41 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.54 Pain Relevance 0
Transfection of NRF2 siRNA in cancer cells decreased the NRF2 message by 80% and simultaneously downregulated the expression of NRF2 target genes (Figure 6B).
Negative_regulation (downregulated) of Gene_expression (expression) of NRF2 associated with cancer
9) Confidence 0.41 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.42 Pain Relevance 0
In the skin, although several Nrf2-dependent ROS-detoxifying enzymes are found upregulated in wound healing, abrogation of Nrf2 expression in transgenic mice is substantially irrelevant for the healing process, whereas it is essential for the effective detoxification of chemical carcinogens [12].
Negative_regulation (abrogation) of Gene_expression (expression) of Nrf2 in skin associated with targeted disruption and wound healing
10) Confidence 0.18 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.25 Pain Relevance 0.11

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