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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.82
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
Anatomy Link Frequency
hinge 1
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 95.72 Very High Very High Very High
Glutamate 22 94.04 High High
metalloproteinase 1 91.20 High High
tolerance 3 87.04 High High
palliative 2 66.00 Quite High
antidepressant 1 60.08 Quite High
anticonvulsant 1 57.40 Quite High
Mechanosensation 1 43.40 Quite Low
Inflammation 31 37.36 Quite Low
Acute pain 1 33.92 Quite Low
Disease Link Frequency Relevance Heat
Stress 212 99.48 Very High Very High Very High
INFLAMMATION 38 95.00 High High
Apoptosis 30 88.80 High High
Wound Healing 1 86.40 High High
Cancer 221 85.80 High High
Targeted Disruption 10 85.24 High High
Toxicity 20 84.68 Quite High
Non-small-cell Lung Cancer 48 80.40 Quite High
Lung Cancer 110 76.36 Quite High
Heat Stress Disorders 1 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nrf2 was immunoprecipitated with an anti-Nrf2 antibody and subjected to immunoblot analysis with an antiubiquitin antibody (Sigma Chemical Co.).

Nrf2 Binding (immunoprecipitated) of
1) Confidence 0.37 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0 Pain Relevance 0
Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase.
Nrf2 Binding (interaction) of
2) Confidence 0.36 Published 2002 Journal Free Radic. Biol. Med. Section Title Doc Link 11909699 Disease Relevance 0.10 Pain Relevance 0.19
Expression of the wild-type KEAP1 in H838 cells stably expressing an ARE reporter completely abolished ARE reporter activity, whereas overexpression of the KEAP1 mutant construct did not, suggesting that the somatic mutations hamper the association between KEAP1 and NRF2 and consequently activate NRF2.
NRF2 Binding (association) of
3) Confidence 0.35 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.75 Pain Relevance 0
NRF2 activates transcription of its target genes through binding specifically to the antioxidant response element (ARE) found in those gene promoters.
NRF2 Binding (binding) of
4) Confidence 0.34 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0.82 Pain Relevance 0.10
Nrf2 activates the transcription of a multitude of downstream anti-oxidant genes via binding to the cis-acting anti-oxidant response element (ARE) of these genes (Nguyen et al., 2004).
Nrf2 Binding (binding) of
5) Confidence 0.31 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.58 Pain Relevance 0
The “hinge and latch” model of Nrf2 regulation proposes that two distinct binding sites in Nrf2 facilitate the interaction with a Keap1 dimer (8).
Nrf2 Binding (binding) of in hinge
6) Confidence 0.26 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.38 Pain Relevance 0
The major ARE-binding transcription factor is nuclear factor-erythroid 2-related factor 2 (Nrf2), which, through heteromeric interaction with the small Maf proteins, binds the ARE and initiates the de novo expression of detoxifying enzymes [11].
Nrf2 Binding (binds) of
7) Confidence 0.21 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.17 Pain Relevance 0.09
Although Nrf2 is the only known substrate of Keap1, the latter has been reported to associate with several other proteins in mammalian cells (7, 13–17).
Nrf2 Binding (associate) of
8) Confidence 0.19 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878012 Disease Relevance 0.07 Pain Relevance 0
Without such stresses, Nrf2 is normally repressed by the oxidative stress sensor Keap1 [38], which binds and degrades Nrf2 through the ubiquitin-proteasome system.
Nrf2 Binding (binds) of associated with stress
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2822842 Disease Relevance 0.95 Pain Relevance 0.10

General Comments

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