INT101836

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.12
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

CYP3A (Homo sapiens)
Pain Link Frequency Relevance Heat
sSRI 7 91.80 High High
agonist 1 88.40 High High
fluoxetine 3 82.64 Quite High
Opioid 1 75.00 Quite High
depression 1 60.60 Quite High
antidepressant 1 59.80 Quite High
Serotonin 1 58.12 Quite High
methadone 7 50.00 Quite Low
Disease Link Frequency Relevance Heat
Syndrome 1 62.08 Quite High
Depression 1 60.60 Quite High
Repression 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These inhibition data were compared with ketoconazole, which was included as a positive control of CYP3A inhibition.
Regulation (control) of Negative_regulation (inhibition) of CYP3A
1) Confidence 0.62 Published 2002 Journal J Clin Psychopharmacol Section Abstract Doc Link 11910261 Disease Relevance 0.12 Pain Relevance 0.53
A crossover clinical investigation (control, CYP2B6 and CYP3A4 induction by rifampin, CYP3A inhibition by troleandomycin and grapefruit juice) evaluated stereoselective methadone disposition.
Regulation (control) of Negative_regulation (inhibition) of CYP3A
2) Confidence 0.33 Published 2008 Journal Anesthesiology Section Body Doc Link 18292673 Disease Relevance 0 Pain Relevance 0
No previous studies have been conducted to determine the effect of in vivo inhibition of CYP3A on the pharmacokinetics and pharmacodynamics of LAAM.
Spec (determine) Regulation (effect) of Negative_regulation (inhibition) of CYP3A
3) Confidence 0.08 Published 2004 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 15289792 Disease Relevance 0 Pain Relevance 0.12

General Comments

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