INT10184

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Context Info
Confidence 0.62
First Reported 1989
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 44
Total Number 50
Disease Relevance 23.78
Pain Relevance 10.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (EDN1) extracellular region (EDN1) cell-cell signaling (EDN1)
cytoplasm (EDN1)
Anatomy Link Frequency
plasma 4
skin 4
ileum 2
spinal cord 2
chondrocytes 1
EDN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 142 100.00 Very High Very High Very High
bradykinin 48 100.00 Very High Very High Very High
aspirin 4 100.00 Very High Very High Very High
anesthesia 4 100.00 Very High Very High Very High
tetrodotoxin 14 99.84 Very High Very High Very High
Spinal cord 8 99.82 Very High Very High Very High
calcitonin gene related peptide 1 99.80 Very High Very High Very High
Calcium channel 29 99.52 Very High Very High Very High
Inflammatory response 12 99.44 Very High Very High Very High
headache 15 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pulmonary Hypertension 162 99.98 Very High Very High Very High
Cancer 117 99.80 Very High Very High Very High
Diabetes Mellitus 340 99.70 Very High Very High Very High
Glaucoma 303 99.68 Very High Very High Very High
Necrosis 11 99.52 Very High Very High Very High
INFLAMMATION 104 99.26 Very High Very High Very High
Sarcoidosis 219 99.08 Very High Very High Very High
Headache Disorders 2 99.04 Very High Very High Very High
Scotoma 6 98.68 Very High Very High Very High
Osteoarthritis 108 98.66 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have used the whole-cell voltage-clamp technique to study the effects of endothelin 1 (ET-1, 10 nM) on L-type Ca2+ currents and voltage-dependent Na+ inward currents in human cardiac cells.
Regulation (effects) of ET-1
1) Confidence 0.62 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8834492 Disease Relevance 0 Pain Relevance 0
We have used the whole-cell voltage-clamp technique to study the effects of endothelin 1 (ET-1, 10 nM) on L-type Ca2+ currents and voltage-dependent Na+ inward currents in human cardiac cells.
Regulation (effects) of endothelin 1
2) Confidence 0.62 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8834492 Disease Relevance 0 Pain Relevance 0
The contractile effect of ET-1 was not affected by tetrodotoxin (1 microM), atropine (1 microM), methysergide (100 nM), chloropyramine (100 nM) or SR140333 (100 nM) but was significantly inhibited or even abolished by the receptor antagonist BQ123 (3 microM) or BQ788 (3 microM).
Neg (not) Regulation (affected) of ET-1 associated with tetrodotoxin and antagonist
3) Confidence 0.60 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906840 Disease Relevance 0 Pain Relevance 0.84
Nevertheless, recent results from our studies in patients with diabetes indicate that targeting the ET-1 system might be of importance in the treatment of complications related to diabetic microangiopathy.



Regulation (targeting) of ET-1 associated with diabetic angiopathy and diabetes mellitus
4) Confidence 0.59 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 1.06 Pain Relevance 0.04
In addition, POMC gene delivery significantly decreased the ET-1 release (P < 0.001) without affecting the ET-1 messenger RNA (mRNA) level.
Neg (without) Regulation (affecting) of ET-1
5) Confidence 0.51 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 16740999 Disease Relevance 0.20 Pain Relevance 0.14
This study examined the effect of ET-1 on cholinergic contractions in human isolated bronchus.
Spec (examined) Regulation (effect) of ET-1 in bronchus
6) Confidence 0.45 Published 1999 Journal Eur. Respir. J. Section Abstract Doc Link 10515427 Disease Relevance 0.18 Pain Relevance 0.06
The effect of ET-1 on these EFS-evoked contractions was assessed.
Regulation (effect) of ET-1
7) Confidence 0.45 Published 1999 Journal Eur. Respir. J. Section Abstract Doc Link 10515427 Disease Relevance 0.18 Pain Relevance 0.15
MEASUREMENTS AND MAIN RESULTS: The arterial and venous ET-1 levels did not change after the induction of anesthesia.
Neg (not) Regulation (change) of ET-1
8) Confidence 0.45 Published 1995 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 8547550 Disease Relevance 0 Pain Relevance 0
Effects of endothelin 1 on calcium and sodium currents in isolated human cardiac myocytes.
Regulation (Effects) of endothelin 1 in cardiac myocytes
9) Confidence 0.45 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 8834492 Disease Relevance 0 Pain Relevance 0.03
Due to the possible involvement of endothelin in headache disorders, the objective of this study was to verify the effects of lithium and cyclooxygenase inhibitors (indomethacin, acetylsalicylic acid and naproxen) on endothelin-1 (ET-1)-induced contractions in isolated human temporal arteries and porcine ophthalmic arteries.
Regulation (effects) of ET-1 associated with aspirin and headache
10) Confidence 0.45 Published 1992 Journal Headache Section Abstract Doc Link 1468903 Disease Relevance 0.61 Pain Relevance 0.65
Due to the possible involvement of endothelin in headache disorders, the objective of this study was to verify the effects of lithium and cyclooxygenase inhibitors (indomethacin, acetylsalicylic acid and naproxen) on endothelin-1 (ET-1)-induced contractions in isolated human temporal arteries and porcine ophthalmic arteries.
Regulation (effects) of endothelin-1 associated with aspirin and headache
11) Confidence 0.45 Published 1992 Journal Headache Section Abstract Doc Link 1468903 Disease Relevance 0.61 Pain Relevance 0.64
The improvement in both coronary artery constriction and CBF is closely related to estrogen-induced changes in the coronary sinus ET-1 levels.
Regulation (changes) of ET-1 in coronary sinus
12) Confidence 0.44 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515431 Disease Relevance 0.24 Pain Relevance 0.04
We have investigated the effects of human endothelin-1 (ET-1) and CRF in the guinea-pig ileum longitudinal and circular preparations and sought for ways of specific antagonism.
Spec (investigated) Regulation (effects) of endothelin-1 in ileum
13) Confidence 0.44 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906840 Disease Relevance 0 Pain Relevance 0.46
We have investigated the effects of human endothelin-1 (ET-1) and CRF in the guinea-pig ileum longitudinal and circular preparations and sought for ways of specific antagonism.
Spec (investigated) Regulation (effects) of ET-1 in ileum
14) Confidence 0.44 Published 2003 Journal Neuropeptides Section Abstract Doc Link 12906840 Disease Relevance 0 Pain Relevance 0.46
The present study was performed to evaluate the influence of IL-1beta on the endothelin (ET)/ET receptor system in human myometrial cells.
Regulation (influence) of endothelin
15) Confidence 0.44 Published 2005 Journal Endocrinology Section Abstract Doc Link 16109787 Disease Relevance 0.14 Pain Relevance 0.16
Alterations in the vascular responsiveness to ET-1 or changes in synthesis, activation, and removal of the molecule may therefore result in impaired regulation of ocular blood flow.
Regulation (Alterations) of ET-1 in blood
16) Confidence 0.43 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.17 Pain Relevance 0
In summary endothelial dysfunction is likely related to glaucoma, but the exact role of mediators such as NO, NOS, ET-1, and ETA/ETB in OAG pathophysiology has yet to be fully appreciated.
Regulation (role) of ET-1 associated with glaucoma
17) Confidence 0.43 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.66 Pain Relevance 0.18
Several studies show that calcium channel antagonists reduce the effect of increased levels of ET-1 on ocular perfusion and improve visual field defects through induced vasodilation (Flammer et al 2001).
Regulation (effect) of ET-1 associated with scotoma, antagonist, calcium channel and increased venous pressure under development
18) Confidence 0.43 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699797 Disease Relevance 1.52 Pain Relevance 0.61
We investigated the influence of the endothelin-A-selective receptor antagonist PD 147953 and the nonselective endothelin receptor antagonist PD 145065 on the effects of endothelin-1 and endothelin-3 in the skin microcirculation of healthy volunteers, using laser Doppler flowmetry.
Spec (investigated) Regulation (influence) of endothelin in skin associated with antagonist
19) Confidence 0.40 Published 1994 Journal Hypertension Section Abstract Doc Link 8175165 Disease Relevance 0.17 Pain Relevance 0.21
We investigated the influence of the endothelin-A-selective receptor antagonist PD 147953 and the nonselective endothelin receptor antagonist PD 145065 on the effects of endothelin-1 and endothelin-3 in the skin microcirculation of healthy volunteers, using laser Doppler flowmetry.
Regulation (effects) of endothelin-1 in skin associated with antagonist
20) Confidence 0.40 Published 1994 Journal Hypertension Section Abstract Doc Link 8175165 Disease Relevance 0.23 Pain Relevance 0.22

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