INT101857

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Context Info
Confidence 0.57
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 23.56
Pain Relevance 3.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BCL2L1) mitochondrion (BCL2L1) growth (BCL2L1)
cytoskeleton (BCL2L1) nucleus (BCL2L1) intracellular (BCL2L1)
Anatomy Link Frequency
SiHa 1
HeLa 1
superior 1
colon 1
A549 1
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 36 100.00 Very High Very High Very High
cINOD 117 99.98 Very High Very High Very High
dexamethasone 5 99.84 Very High Very High Very High
agonist 47 98.08 Very High Very High Very High
rheumatoid arthritis 1 85.60 High High
Inflammation 175 73.28 Quite High
COX-2 inhibitor 210 71.84 Quite High
cytokine 60 70.16 Quite High
diclofenac 5 70.16 Quite High
acular 2 69.12 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 1030 100.00 Very High Very High Very High
Breast Cancer 144 99.84 Very High Very High Very High
Cancer 1064 99.70 Very High Very High Very High
Death 200 99.54 Very High Very High Very High
Non-small-cell Lung Cancer 15 99.50 Very High Very High Very High
Colon Cancer 185 99.30 Very High Very High Very High
Hepatocellular Cancer 30 99.12 Very High Very High Very High
Reprotox - General 1 65 98.92 Very High Very High Very High
INFLAMMATION 206 96.12 Very High Very High Very High
Pancreatic Cancer 13 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSAIDs downregulate Bcl-X(L) and dissociate BAX and Bcl-X(L) to induce apoptosis in colon cancer cells.
Negative_regulation (downregulate) of Bcl-X in colon associated with colon cancer, cinod and apoptosis
1) Confidence 0.57 Published 2008 Journal Nutr Cancer Section Title Doc Link 19003586 Disease Relevance 1.17 Pain Relevance 0.90
We found that Bcl-X(L) is downregulated by NSAIDs in part through proteasome-mediated protein degradation.
Negative_regulation (downregulated) of Bcl-X associated with cinod
2) Confidence 0.57 Published 2008 Journal Nutr Cancer Section Abstract Doc Link 19003586 Disease Relevance 1.20 Pain Relevance 0.92
These processes were accompanied by caspase activation and downregulation of the antiapoptotic proteins Bcl-2 and Bcl-x(L).
Negative_regulation (downregulation) of Bcl-x
3) Confidence 0.42 Published 2010 Journal Invest New Drugs Section Abstract Doc Link 19139819 Disease Relevance 0.91 Pain Relevance 0.10
Bak expression was increased by celecoxib and dexamethasone, while Bcl-XL level was declined only by dexamethasone.
Negative_regulation (declined) of Bcl-XL associated with dexamethasone
4) Confidence 0.29 Published 2009 Journal Toxicology Section Abstract Doc Link 19428934 Disease Relevance 0.93 Pain Relevance 1.14
Bcl-XL decreased.
Negative_regulation (decreased) of Bcl-XL
5) Confidence 0.26 Published 2007 Journal PPAR Research Section Body Doc Link PMC1852897 Disease Relevance 0.99 Pain Relevance 0
Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L).
Negative_regulation (inhibition) of Bcl-x associated with colon cancer and apoptosis
6) Confidence 0.20 Published 2002 Journal Cancer Res. Section Title Doc Link 11912124 Disease Relevance 1.47 Pain Relevance 0
Results obtained with human nonsmall cell lung cancer A549 cells suggest that downregulation of Bcl-xL, COX-2, and MAP kinase pathway and up-regulation of p53, Akt, and NF?
Negative_regulation (downregulation) of Bcl-xL in A549 associated with non-small-cell lung cancer
7) Confidence 0.11 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.04 Pain Relevance 0.03
Curcumin-mediated apoptosis in these cells is initiated by up-regulation of pro-apoptotic Bax, AIF, release of cytochrome c, and downregulation of anti-apoptotic Bcl-2, Bcl-xL in HeLa and SiHa cell lines.
Negative_regulation (downregulation) of Bcl-xL in HeLa associated with apoptosis
8) Confidence 0.11 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.22 Pain Relevance 0
This effect was due to an upregulation of TRAIL receptors (TRAIL R2/DR5 and TRAIL-R1/DR4), together with an ability of the compounds to induce a down-regulation of the anti-apoptotic proteins survivin (IAP) and Bcl-xL [121].
Negative_regulation (regulation) of Bcl-xL associated with apoptosis
9) Confidence 0.11 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.51 Pain Relevance 0.09
HSF1-silenced cells showed dramatically elevated levels of JNK1 phosphorylation, which is a trigger for apoptosis, as well as decreased levels of Bcl-xL, which is an inhibitor of apoptosis.
Negative_regulation (decreased) of Bcl-xL associated with apoptosis
10) Confidence 0.11 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.76 Pain Relevance 0
The reduction in Bcl-xL is due to diminished protein levels rather than reduced mRNA expression, which suggests that the inability of HSF1-silenced cells to mount a heat shock response leads to an increased turnover of Bcl-xL protein.
Negative_regulation (reduction) of Bcl-xL associated with shock
11) Confidence 0.11 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.76 Pain Relevance 0
We also observed that silencing BAG3 was associated with a dramatic loss in proteins belonging to the antiapoptotic Bcl-2 family, including Bcl-2, Bcl-xL, and Mcl-1.
Negative_regulation (loss) of Bcl-xL
12) Confidence 0.11 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.67 Pain Relevance 0
These findings suggest that the superior sequence-dependent anti-breast cancer activity of EpoB followed by flavopiridol may be due to flavopiridol-induced bax conformational change and downregulation of the anti-apoptotic IAP bcl-xL and Mcl-1 proteins, but this treatment may not overcome the resistance to apoptosis of breast cancer cells conferred by over-expression of bcl-2.
Negative_regulation (downregulation) of bcl-xL in superior associated with breast cancer and apoptosis
13) Confidence 0.10 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.92 Pain Relevance 0.03
In this system, the NSAID-provoked cell death was associated with a downregulation of Bax-antagonist Bcl-XL.
Negative_regulation (downregulation) of Bcl-XL associated with antagonist, cinod and death
14) Confidence 0.09 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.37 Pain Relevance 0.37
Several homologues of Bcl-2 protein have also been shown to act as inhibitors of apoptosis, including Bcl-Xl and others as apoptotic proteins such as Bax.
Negative_regulation (inhibitors) of Bcl-Xl associated with apoptosis
15) Confidence 0.08 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.29 Pain Relevance 0.04
Specifically, Bcl-xl, an antiapoptotic protein, has been shown to be decreased in breast cancer [71–73], prostate cancer [74], and other cancers [75–77] upon treatment with genistein.
Negative_regulation (decreased) of Bcl-xl associated with cancer, breast cancer and reprotox - general 1
16) Confidence 0.07 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 1.38 Pain Relevance 0
Many anti-cancer drugs trigger mitochondria-mediated apoptosis in cancer cells through downregulation of Bcl-2/Bcl-xL and/or upregulation of Bax/Bad/Bid.
Negative_regulation (downregulation) of Bcl-xL associated with cancer and apoptosis
17) Confidence 0.07 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 0.86 Pain Relevance 0
ligand PGJ2 induces both CDK p21 and the proapoptotic Bax but downregulates the anti-apoptotic Bcl-xL [163].
Negative_regulation (downregulates) of Bcl-xL associated with apoptosis
18) Confidence 0.07 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.76 Pain Relevance 0.19
In particular, induction of pro-apoptotic Bim and in some instances, a decrease in pro-survival Bcl-xL is critical for HDACi mediated apoptosis [64, 67, 69, 76, 79].
Negative_regulation (decrease) of Bcl-xL associated with apoptosis
19) Confidence 0.06 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.55 Pain Relevance 0
Curcumin-mediated apoptosis in these cells is initiated by up-regulation of pro-apoptotic Bax, AIF, release of cytochrome c, and downregulation of anti-apoptotic Bcl-2, Bcl-xL in HeLa and SiHa cell lines.
Negative_regulation (downregulation) of Bcl-xL in SiHa associated with apoptosis
20) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.22 Pain Relevance 0

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