INT101859

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Context Info
Confidence 0.49
First Reported 2001
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 34
Total Number 36
Disease Relevance 19.45
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MCF2) cytoskeleton (MCF2) cytoplasm (MCF2)
Anatomy Link Frequency
MCF-7 22
MDA-MB-231 4
MCF7 3
SH-SY5Y 1
HBL-100 1
MCF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 10 99.70 Very High Very High Very High
opioid receptor 1 99.52 Very High Very High Very High
Morphine 1 97.04 Very High Very High Very High
analgesia 1 96.68 Very High Very High Very High
antagonist 21 95.28 Very High Very High Very High
MU agonist 1 95.20 Very High Very High Very High
Central nervous system 4 77.04 Quite High
anesthesia 2 73.96 Quite High
rheumatoid arthritis 81 72.24 Quite High
Action potential 2 69.36 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 1055 100.00 Very High Very High Very High
Cancer 726 100.00 Very High Very High Very High
Adenocarcinoma 42 100.00 Very High Very High Very High
Malignant Neoplastic Disease 36 100.00 Very High Very High Very High
Apoptosis 624 99.12 Very High Very High Very High
Down Syndrome 1 97.56 Very High Very High Very High
Aggression 42 97.52 Very High Very High Very High
Herpes Zoster 4 97.28 Very High Very High Very High
Neuroblastoma 8 96.84 Very High Very High Very High
Carcinoma 18 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The observed cytostatic effect against the human breast cancer cell line MCF-7/ADR, highly expressing sigma(1) receptors, and not against MCF-7, as well as the enhancement of morphine analgesia highlighted the sigma(1) antagonist profile of this series of compounds.
Gene_expression (expressing) of MCF-7 in MCF-7 associated with antagonist, breast cancer, analgesia and morphine
1) Confidence 0.49 Published 2010 Journal J. Med. Chem. Section Abstract Doc Link 20067271 Disease Relevance 0.10 Pain Relevance 0.31
The cancer IBH-6, IBH-7 and MCF-7 and the non-tumour HBL-100 cells line, expressed both alpha(2B)- and alpha(2C)-adrenoceptor-subtypes.
Gene_expression (expressed) of MCF-7 in HBL-100 associated with cancer
2) Confidence 0.13 Published 2006 Journal Cancer Chemother. Pharmacol. Section Abstract Doc Link 16292538 Disease Relevance 0.72 Pain Relevance 0.11
COX-2 expression was induced in MCF-7 cells stably transfected with HER2, in contrast to parental MCF-7 cells, and was detected in MDA-MB-231, but not SK-BR-3 cells.
Gene_expression (transfected) of MCF-7 in MCF-7
3) Confidence 0.10 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11912139 Disease Relevance 1.08 Pain Relevance 0.10
Itoh et al. [89] also found differences between letrozole, anastrozole, and tamoxifen using microarray analysis on MCF-7 cells stably transfected with the aromatase gene (MCF-7Aro).
Gene_expression (transfected) of MCF-7Aro in MCF-7
4) Confidence 0.07 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.26 Pain Relevance 0
MCF-7aro cells deprived of hormones showed 91.3 ± 2.1% of cells in G0/G1 phase, whereas in testosterone-induced growth of MCF-7aro cells (control cells), the percentage of cells arrested in G0/G1 phase was only 42.4 ± 2.3%, which indicates that aromatase present in MCF-7aro is converting testosterone into estradiol, inducing in that way cell proliferation.
Gene_expression (present) of MCF-7aro
5) Confidence 0.06 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2515307 Disease Relevance 0 Pain Relevance 0
MCF-7aro cells were seeded in 8-chamber wells and treated with compounds 3a and 4a (25 ?
Gene_expression (seeded) of MCF-7aro
6) Confidence 0.06 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2515307 Disease Relevance 0.13 Pain Relevance 0
The ER-positive aromatase-overexpressing human breast cancer MCF-7 cell line, MCF-7aro, prepared by stable transfection with the human placental aromatase gene and Geneticin selection [32], was kindly provided by Dr.
Gene_expression (overexpressing) of MCF-7aro in MCF-7 associated with breast cancer
7) Confidence 0.06 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2515307 Disease Relevance 0.10 Pain Relevance 0
On the other hand, lack of overexpression of the proto-oncogene ets-2, encoded on chromosome 21, in heart tissue of patients with Down syndrome provides evidence against a gene-dosage effect of polysomies [40].
Gene_expression (overexpression) of proto-oncogene ets-2 in heart associated with down syndrome
8) Confidence 0.06 Published 2001 Journal Arthritis Res Section Body Doc Link PMC64845 Disease Relevance 0.67 Pain Relevance 0.10
Itoh et al. [89] also found differences between letrozole, anastrozole, and tamoxifen using microarray analysis on MCF-7 cells stably transfected with the aromatase gene (MCF-7Aro).
Gene_expression (transfected) of MCF-7 in MCF-7
9) Confidence 0.06 Published 2007 Journal Breast Cancer Res Treat Section Body Doc Link PMC2001220 Disease Relevance 0.26 Pain Relevance 0
It is now well established that breast cancer cell line MCF-7 expresses E2 receptors (ER+), and that 17-?
Gene_expression (expresses) of MCF-7 in MCF-7 associated with breast cancer
10) Confidence 0.05 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.88 Pain Relevance 0.07
g/mL, displayed antiproliferative effects on both MCF-7 (ER+) and MDA-MB-231 (ER?)
Gene_expression (effects) of MCF-7 in MDA-MB-231
11) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 1.11 Pain Relevance 0
As shown in Figure 2, treatment of both MCF-7 and MDA-MB-231 cells with 5-FU (0.5 ?
Gene_expression (treatment) of MCF-7 in MDA-MB-231
12) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.32 Pain Relevance 0
The model cell lines (MCF-7/HER2 and BT 474) were treated with the I?
Gene_expression (/) of MCF-7 in MCF-7
13) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.08 Pain Relevance 0
Bortezomib induced apoptosis in HER2-positive (SKBR-3, MDA-MB-453, HER2 transfected MCF-7) and HER2-negative breast cancer cells (MCF-7) in a dose-dependent and time-dependent manner.
Gene_expression (transfected) of MCF-7 in MCF-7 associated with breast cancer and apoptosis
14) Confidence 0.04 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.81 Pain Relevance 0
Cell Culture
     The human breast adenocarcinoma ER+  (MCF-7) and ER? 
Gene_expression (Cell) of MCF-7 in MCF-7 associated with adenocarcinoma
15) Confidence 0.04 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2730474 Disease Relevance 0.44 Pain Relevance 0
In the present study, we examined the expression and function of TRPM8 in the ER+ human breast cancer cell line MCF-7.
Spec (examined) Gene_expression (expression) of MCF-7 in MCF-7 associated with breast cancer
16) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.86 Pain Relevance 0.06
MCF-7 cells were transfected as previously described [26] using 2 ?
Gene_expression (transfected) of MCF-7 in MCF-7
17) Confidence 0.04 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 0.06 Pain Relevance 0
The human breast adenocarcinoma cell line MCF-7 (obtained from ATCC) was routinely cultured in Dulbecco's Modified Eagle's Medium (DMEM) containing 10% fetal bovine serum (FBS) and Penicillin/Streptomycin (100 U/100 ?
Gene_expression (cultured) of MCF-7 in MCF-7 associated with adenocarcinoma
18) Confidence 0.03 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.10 Pain Relevance 0
Fay M et al; in 2003 [49] reported underexpression of the CUL-5 gene in breast tumor tissue, whereas expression levels in several cancer cell lines (MCF7, MDA-MB-231) are essentially identical to those of normal breast.
Gene_expression (expression) of MCF7 in MDA-MB-231 associated with cancer and breast cancer
19) Confidence 0.03 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 1.14 Pain Relevance 0
In the present study we report the differential actin cytoskeleton reorganization induced by opioids in malignant (MCF7) and nonmalignant (MCF12A) breast epithelial cells expressing functional opioid receptors.
Gene_expression (expressing) of MCF7 in MCF7 associated with malignant neoplastic disease, opioid receptor and opioid
20) Confidence 0.02 Published 2003 Journal Exp. Cell Res. Section Abstract Doc Link 12878162 Disease Relevance 0.59 Pain Relevance 0.47

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