INT10187

Context Info Confidence 0.78 First Reported 1992 Last Reported 2010 Negated 3 Speculated 4 Reported most in Body Documents 91 Total Number 96 Disease Relevance 52.67 Pain Relevance 16.66

Anatomy Link Frequency T cells 31 lymphocytes 6 IL2R 6 CSF 3 spleen 3 Il2ra (Mus musculus)

Pain Link Frequency Relevance Heat cytokine 556 99.88 Inflammation 619 99.74 depression 28 98.88 Arthritis 69 98.80 qutenza 36 98.68 substance P 100 98.66 ischemia 72 98.62 Neuritis 19 98.36 Angina 20 98.32 Central grey 25 98.28

Disease Link Frequency Relevance Heat Cancer 1241 99.90 Systemic Mastocytosis 81 99.76 INFLAMMATION 652 99.74 Targeted Disruption 121 99.44 Necrosis 33 99.40 Frailty 8 99.16 Inflammatory Bowel Disease 85 99.12 Arthritis 99 98.92 Nicotine Addiction 182 98.88 Depression 33 98.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

While IL2 receptor (IL2R) was expressed on 20-50% of tumor cells prior to therapy, recurrent tumor was IL2R negative in three of the patients.

Neg (negative) Gene_expression (negative) of IL2R in IL2R associated with cancer

1) Confidence 0.78 Published 1998 Journal Am. J. Hematol. Section Abstract Doc Link 9590158 Disease Relevance 1.07 Pain Relevance 0.08

While IL2 receptor (IL2R) was expressed on 20-50% of tumor cells prior to therapy, recurrent tumor was IL2R negative in three of the patients.

Gene_expression (expressed) of IL2 receptor in IL2R associated with cancer

2) Confidence 0.78 Published 1998 Journal Am. J. Hematol. Section Abstract Doc Link 9590158 Disease Relevance 1.09 Pain Relevance 0.08

While IL2 receptor (IL2R) was expressed on 20-50% of tumor cells prior to therapy, recurrent tumor was IL2R negative in three of the patients.

Gene_expression (expressed) of IL2R in IL2R associated with cancer

3) Confidence 0.78 Published 1998 Journal Am. J. Hematol. Section Abstract Doc Link 9590158 Disease Relevance 1.09 Pain Relevance 0.08

Transfer activity was lost when cells were depleted of CD4(+) or CD25(+) subpopulations.

Gene_expression (depleted) of CD25

4) Confidence 0.66 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15879089 Disease Relevance 0.39 Pain Relevance 0.14

This result suggests that a penetrating ocular injury at an early stage after an AC injection of OVA does not alter the expression of CD4+CD25+Foxp3+T cells and thereby does not result in the induction of ACAID.

Gene_expression (expression) of CD25 in T cells associated with ocular injury

5) Confidence 0.61 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.59 Pain Relevance 0.03

Mucosal mast cells were quantitated, and the presence or absence of CD25 expression on mast cells was determined.

Gene_expression (expression) of CD25 in mast cells

6) Confidence 0.57 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 2.29 Pain Relevance 0.23

Recently, expression of CD25 by mast cells in bone marrow has been shown to be specific for SM.

Gene_expression (expression) of CD25 in mast cells associated with systemic mastocytosis

7) Confidence 0.57 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 1.53 Pain Relevance 0.15

(CD25) and/or production of certain immunoregulatory cytokines [33, 34].

Gene_expression (production) of CD25 associated with cytokine

8) Confidence 0.54 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.23 Pain Relevance 0.18

CD25, i.e. the IL2R, is more easily detected in vitro), and to its kinetics, peaking relatively late (whereas e.g.

Gene_expression (detected) of IL2R in IL2R

9) Confidence 0.53 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.28 Pain Relevance 0

Unfortunately, the cell surface proteins on Tregs (for example; CD25, CTLA4) are also expressed on other immune cells such as activated T lymphocytes [46].

Gene_expression (expressed) of CD25 in T lymphocytes

10) Confidence 0.53 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.73 Pain Relevance 0.05

Lastly, we observed an expansion of CD4+CD25+FoxP3+ Treg during the induction of ACAID.

Gene_expression (expansion) of CD25

11) Confidence 0.50 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0.27 Pain Relevance 0

In addition, mast cells in all SM cases were positive for CD25, whereas GI mucosal mast cells in UP and all other control cases were negative.

Gene_expression (positive) of CD25 in mast cells associated with systemic mastocytosis and urticaria pigmentosa

12) Confidence 0.50 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 1.99 Pain Relevance 0.14

Strikingly, M2-transduced cells expressed higher levels of CD25 as compared to cells transduced with the control retrovirus, although the MFI of CD25 was similar between the two populations (Figure 3A).

Gene_expression (expressed) of CD25

13) Confidence 0.47 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.16 Pain Relevance 0

profile after gating on the CD4+CD25+ and CD4+CD25?

Gene_expression (profile) of CD25

14) Confidence 0.46 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.21 Pain Relevance 0.12

profile after gating on the CD4+CD25+ and CD4+CD25?

Gene_expression (profile) of CD25

15) Confidence 0.46 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.21 Pain Relevance 0.12

The frequency of Tregs determined as CD4+CD25+CD127lowFOXP3+ was followed in blood, spleen and PDLN of mice immunised at 9 weeks of age.

Gene_expression (followed) of CD25 in blood

16) Confidence 0.46 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.60 Pain Relevance 0

Interestingly, as shown in Fig. 6a, upon in vitro re-stimulation with plate-bound anti-CD3 and soluble anti-CD28, CD4+CD25+ and CD4+CD25?

Gene_expression (shown) of CD25

17) Confidence 0.46 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.38 Pain Relevance 0.09

CD25, i.e. the IL2R, is more easily detected in vitro), and to its kinetics, peaking relatively late (whereas e.g.

Gene_expression (detected) of CD25 in IL2R

18) Confidence 0.46 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 0.28 Pain Relevance 0

In our study, we have demonstrated that repetitive PTx treatment elevated frequency as well as mean FoxP3 expression of CD4+CD25+FoxP3+ T cells.

Gene_expression (expression) of CD25 in T cells

19) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 0.65 Pain Relevance 0.18

At four days post-transduction, B cells expressing M2 were CD19+, CD25high, GL7high, B220low, I-Ab low, surface IgD?

Gene_expression (transduction) of CD25high in B cells

20) Confidence 0.41 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.15 Pain Relevance 0

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