INT10188

Context Info Confidence 0.45 First Reported 1982 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 19 Total Number 22 Disease Relevance 11.60 Pain Relevance 3.37

Anatomy Link Frequency T cells 8 regulatory T cells 3 CSF 1 dendritic cells 1 Regulatory T-cell 1 Il2ra (Mus musculus)

Pain Link Frequency Relevance Heat substance P 32 99.80 Inflammation 168 99.12 antagonist 43 99.06 cytokine 152 98.60 Angina 6 98.32 qutenza 15 98.16 cINOD 3 97.72 spastic colon 1 97.48 Bile 1 93.58 withdrawal 7 85.88

Disease Link Frequency Relevance Heat Contact Dermatitis 5 99.92 Gastroenteritis 1 99.88 Targeted Disruption 90 99.78 Disease 77 99.70 Rhinitis 12 99.56 Lung Cancer 16 99.40 Inflammatory Bowel Disease 6 99.12 Cancer 375 98.68 Parasitic Infection 3 98.56 Cv General 3 Under Development 5 98.32

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Within this family, IL-2 is a prototypic activating cytokine, secreted by and selectively signaling activated T cells, as well as up-regulating its own receptor (IL-2R).

Positive_regulation (up-regulating) of IL-2R in T cells associated with cytokine

1) Confidence 0.45 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0.08 Pain Relevance 0.18

On day 0, beta blockade was evident by increased CD25 values of 618 micrograms for pindolol, 57 micrograms for propranolol, and 10 micrograms for metoprolol as compared to 2.8, 2.4, and 3.0 microgram, respectively, at days 14 to 21, which were considered the ultimate baseline.

Spec (evident) Positive_regulation (increased) of CD25

2) Confidence 0.42 Published 1982 Journal Am. Heart J. Section Abstract Doc Link 7102534 Disease Relevance 0.07 Pain Relevance 0.12

Activated CD4+ and CD8+ T lymphocytes upregulate cell surface CD25 after initial binding of the TCR with antigen displayed on MHC [30], [31] and this might explain the apparent decrease in T cells that was observed in tumors (Fig. 4A–B) and dLN (Fig. 4C–D) following administration of PC61.

Positive_regulation (upregulate) of CD25 in T cells associated with cancer

3) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.68 Pain Relevance 0

Seventeen GI biopsies from 6 patients with SM; 17 GI biopsies from 5 patients with UP; and 157 control cases including 10 each normal stomach, duodenum, terminal ileum, and colon, Helicobacter pylori gastritis, bile reflux gastropathy, peptic duodenitis, celiac disease, Crohn disease, ulcerative colitis, lymphocytic colitis, and collagenous colitis, 20 biopsies from 16 patients with irritable bowel syndrome, 8 biopsies from 5 patients with parasitic infections, and 9 biopsies from 7 patients with eosinophilic gastroenteritis were immunostained for mast cell tryptase, c-kit (CD117), and CD25.

Positive_regulation (immunostained) of CD25 in mast cell associated with bile, crohn's disease, spastic colon, gastroenteritis, duodenitis, rhinitis, parasitic infection, celiac disease, collagenous colitis, lymphocytic colitis, systemic mastocytosis, urticaria pigmentosa and gastritis

4) Confidence 0.37 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 2.43 Pain Relevance 0.24

Skin application of ketoprofen systemically suppresses contact hypersensitivity by inducing CD4(+) CD25(+) regulatory T cells.

Positive_regulation (inducing) of CD25 in regulatory T cells associated with contact dermatitis

5) Confidence 0.36 Published 2009 Journal J. Dermatol. Sci. Section Title Doc Link 19157794 Disease Relevance 0.20 Pain Relevance 0.10

The efficient induction of CD25 +CD4 + reguratory T cells is expected for the new type of treatment of AD.

Positive_regulation (induction) of CD25 in T cells associated with eczema

6) Confidence 0.34 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 0.61 Pain Relevance 0.08

In addition to Tregs, CD25 is also expressed on the cell surface of precursor B and T lymphocytes and a mature subpopulation of DC [30] and is also upregulated on the cell surface of activated T lymphocytes and B lymphocytes [31].

Positive_regulation (upregulated) of CD25 in T lymphocytes

7) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 1.55 Pain Relevance 0

Strikingly, M2-transduced cells expressed higher levels of CD25 as compared to cells transduced with the control retrovirus, although the MFI of CD25 was similar between the two populations (Figure 3A).

Positive_regulation (levels) of CD25

8) Confidence 0.31 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.16 Pain Relevance 0

CD4+CD25+ cells were purified by magnetic bead separation using negative selection for CD4+ and subsequent positive selection of CD25+ by incubation with PE-conjugated anti-CD25 (7D4) followed by anti-PE microbeads (CD4+CD25+ Regulatory T-cell Isolation Kit; Miltenyi Biotec).

Positive_regulation (selection) of CD25 in Regulatory T-cell

9) Confidence 0.28 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.14 Pain Relevance 0

-gal protein, both CD4+ and CD8+ T cells from wild type and transgenic mice were activated (CD25+) on day 4 in vitro (Figure 3A).

Positive_regulation (activated) of CD25 in T cells associated with targeted disruption

10) Confidence 0.26 Published 2004 Journal BMC Immunol Section Body Doc Link PMC394319 Disease Relevance 0.71 Pain Relevance 0

As previously described, CD4 help induced the differentiation of highly proliferating memory-like CD8+ T cells into effectors as demonstrated by the dowregulation of CD62L and the upregulation of CD25 in control mice (Fig. 4C) [29].

Positive_regulation (upregulation) of CD25 in T cells

11) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939396 Disease Relevance 0 Pain Relevance 0

The efficient induction of CD25+CD4+ regulatory T cells may become new type of treatment for recalcitrant AD.

Positive_regulation (induction) of CD25 in regulatory T cells associated with eczema

12) Confidence 0.24 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.74 Pain Relevance 0.11

Fig. 7 shows schematically the action mechanism of FoxP3+CD25+CD4+ regulatory T cells, which are conceivable to suppress the induction and exacerbation of AD-like lesions through the suppression of IFN-?

Positive_regulation (regulatory T cells) of CD25 in regulatory T cells associated with eczema

13) Confidence 0.24 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946701 Disease Relevance 0.76 Pain Relevance 0.17

In MSC-treated immunized mice, CD4+CD25+CD27+ Tregs were increased significantly compared with non-MSC-treated mice, and Tregs from these mice inhibited proliferation of T lymphocytes when proliferation was recalled using collagen type II.

Positive_regulation (increased) of CD25 in T lymphocytes

14) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592798 Disease Relevance 0.47 Pain Relevance 0.23

Furthermore, c-maf, independent of IL-4, is also essential for normal induction of CD25 (IL-2R?

Positive_regulation (induction) of CD25

15) Confidence 0.15 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.21 Pain Relevance 0.04

In cases of severe graft vs. host disease with markedly increased sIL2R, sCD40L was not increased in vivo.

Positive_regulation (increased) of sIL2R associated with disease

16) Confidence 0.14 Published 2005 Journal Eur. J. Haematol. Section Abstract Doc Link 15613107 Disease Relevance 0.34 Pain Relevance 0.08

Additionally, H. pylori may regulate the host immune response through activation of dendritic cells and CD25 regulatory T cells, and it may direct immunosuppression of T cells.

Positive_regulation (activation) of CD25 in dendritic cells

17) Confidence 0.10 Published 2004 Journal Curr. Opin. Gastroenterol. Section Body Doc Link 15703614 Disease Relevance 0 Pain Relevance 0

Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.

Positive_regulation (augmentation) of CD25 in T cell associated with qutenza, antagonist and substance p

18) Confidence 0.06 Published 1999 Journal J. Neuroimmunol. Section Abstract Doc Link 10378865 Disease Relevance 0 Pain Relevance 0.86

Previous studies have demonstrated elevated serum levels of interleukin-6 (IL-6) and the soluble interleukin-2 receptor (IL-2R, CD25) in individuals with inflammatory bowel disease (IBD).

Positive_regulation (elevated) of CD25 in bowel associated with inflammatory bowel disease and inflammation

19) Confidence 0.04 Published 1996 Journal J. Pediatr. Gastroenterol. Nutr. Section Abstract Doc Link 8856584 Disease Relevance 1.06 Pain Relevance 0.26

In lung cancer patients ANOVA showed a time effect for cortisol, melatonin, TSH, CD4, CD16, CD25, TcR?

Positive_regulation (effect) of CD25 in lung associated with lung cancer

20) Confidence 0.03 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2910689 Disease Relevance 0.37 Pain Relevance 0

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