INT101883

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Context Info
Confidence 0.52
First Reported 2002
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 6.71
Pain Relevance 2.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Nos3) aging (Nos3) Golgi apparatus (Nos3)
cytoplasm (Nos3) signal transduction (Nos3) oxidoreductase activity (Nos3)
Anatomy Link Frequency
neuronal 4
thoracic aorta 4
endothelial cells 2
plaques 2
platelets 2
Nos3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 60 99.40 Very High Very High Very High
cINOD 1 98.92 Very High Very High Very High
headache 4 98.52 Very High Very High Very High
Migraine 6 97.72 Very High Very High Very High
medulla 76 96.80 Very High Very High Very High
Angina 5 94.00 High High
tolerance 7 91.24 High High
Inflammation 16 89.72 High High
tetrodotoxin 2 82.72 Quite High
ischemia 2 82.60 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 531 100.00 Very High Very High Very High
Hypoxia 53 100.00 Very High Very High Very High
INFLAMMATION 17 98.68 Very High Very High Very High
Headache 9 98.52 Very High Very High Very High
Migraine Without Aura 1 96.56 Very High Very High Very High
Acute Coronary Syndrome 5 95.72 Very High Very High Very High
Increased Venous Pressure Under Development 71 94.24 High High
Cv General 3 Under Development 5 94.00 High High
Impaired Glucose Tolerance 5 91.24 High High
Hyperglycemia 35 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore investigated the effects of chronic exercise on iNOS and eNOS expression in isolated rat aortic endothelial and smooth muscle cells separately.
Spec (investigated) Regulation (effects) of Gene_expression (expression) of eNOS in smooth muscle cells
1) Confidence 0.52 Published 2002 Journal J. Biomed. Sci. Section Abstract Doc Link 11914582 Disease Relevance 0 Pain Relevance 0.08
Total RNA was extracted from the 30 plaques and the cDNA was amplified in order to determine endothelial nitric oxide synthase (eNOS) gene expression.
Spec (determine) Regulation (determine) of Spec (determine) Gene_expression (expression) of endothelial nitric oxide synthase in plaques
2) Confidence 0.34 Published 2005 Journal Eur J Histochem Section Abstract Doc Link 15823793 Disease Relevance 1.28 Pain Relevance 0.37
Effect of STZ-induced diabetes on the concentration of NOx and expression of eNOS and iNOS
Regulation (Effect) of Gene_expression (expression) of eNOS associated with diabetes mellitus
3) Confidence 0.32 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 1.36 Pain Relevance 0.14
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of Gene_expression (expression) of eNOS in thoracic aorta associated with medulla
4) Confidence 0.32 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11
Then, membranes were incubated for another 2 h with the primary monoclonal antibodies [eNOS and iNOS (BD Transduction Laboratories, San Jose, USA) and ?
Regulation (with) of Gene_expression (antibodies) of eNOS
5) Confidence 0.26 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2949609 Disease Relevance 0 Pain Relevance 0
Endothelial NO synthase (eNOS) protein expression was not affected by diet.
Neg (not) Regulation (affected) of Gene_expression (expression) of eNOS
6) Confidence 0.24 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2887873 Disease Relevance 1.27 Pain Relevance 0.26
Unlike that observed for iNOS, acetaminophen did not appear to affect the regulation of nNOS or eNOS expression (Figure 5B) suggesting perhaps that the normalization of Akt S-nitrosylation by acetaminophen may be dependent on the reduced expression of iNOS.
Regulation (regulation) of Gene_expression (expression) of eNOS associated with paracetamol
7) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2712760 Disease Relevance 0.20 Pain Relevance 0.50
The effect of hypoxia on the expression of the endothelial cell isoform of NOS (eNOS) has been evaluated in cultured endothelial cells.
Regulation (effect) of Gene_expression (expression) of eNOS in endothelial cells associated with hypoxia
8) Confidence 0.17 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808559 Disease Relevance 0.50 Pain Relevance 0
However, The expression in pulmonary arteries of the neuronal NO synthase (nNOS), as determined by Western-blot analysis, increased with postnatal age whereas the expression of the endothelial NOS (eNOS) did not change.
Neg (not) Regulation (change) of Gene_expression (expression) of endothelial NOS in neuronal
9) Confidence 0.15 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17440225 Disease Relevance 0 Pain Relevance 0.12
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of in kidney medulla Gene_expression (expression) of eNOS in thoracic aorta associated with medulla
10) Confidence 0.11 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11
The concentration of ET-1, NOx, creatinine and protein expression of preproET-1, iNOS, eNOS, phosphorylated p38-MAPK (pp38-MAPK), total p38-MAPK, phosphorylated ERK, total ERK were determined in the thoracic aorta, kidney cortex and kidney medulla obtained from each animal.


Regulation (concentration) of in kidney cortex Gene_expression (expression) of eNOS in thoracic aorta associated with medulla
11) Confidence 0.11 Published 2005 Journal Cardiovasc Diabetol Section Body Doc Link PMC555576 Disease Relevance 0.41 Pain Relevance 0.11
However, The expression in pulmonary arteries of the neuronal NO synthase (nNOS), as determined by Western-blot analysis, increased with postnatal age whereas the expression of the endothelial NOS (eNOS) did not change.
Neg (not) Regulation (change) of Gene_expression (expression) of eNOS in neuronal
12) Confidence 0.11 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17440225 Disease Relevance 0 Pain Relevance 0.12
Nitric oxide synthase (eNOS and iNOS) expression in platelets and the effects of ONOO- on membrane Na+/K+-ATPase activity and membrane fluidity were also evaluated.
Regulation (evaluated) of Gene_expression (expression) of eNOS in platelets
13) Confidence 0.09 Published 2005 Journal Cephalalgia Section Abstract Doc Link 15839850 Disease Relevance 0.87 Pain Relevance 0.82

General Comments

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