INT101886

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 12
Disease Relevance 4.46
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Fgf2) extracellular space (Fgf2) extracellular region (Fgf2)
nucleus (Fgf2) embryo development (Fgf2) cytoplasm (Fgf2)
Anatomy Link Frequency
myocardium 3
muscles 1
limb muscles 1
fibroblast 1
thigh 1
Fgf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 44 98.40 Very High Very High Very High
Sciatic nerve 6 94.44 High High
Inflammation 40 84.80 Quite High
hypoalgesia 15 82.48 Quite High
diabetic neuropathy 78 77.28 Quite High
Nerve growth factor 42 70.08 Quite High
neurotrophin 3 42 69.44 Quite High
Pain 4 65.24 Quite High
cINOD 1 63.12 Quite High
GABAergic 4 50.12 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 464 99.36 Very High Very High Very High
Infarction 93 99.24 Very High Very High Very High
Myocardial Infarction 153 98.00 Very High Very High Very High
Ganglion Cysts 8 92.16 High High
Apoptosis 23 85.36 High High
INFLAMMATION 41 84.80 Quite High
Hypoalagesia 15 82.48 Quite High
Adhesions 4 81.84 Quite High
Disease 10 81.20 Quite High
Diabetic Neuropathy 81 77.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical and in situ hybridization techniques were used for detecting protein and mRNA expressions for vascular endothelial growth factors (VEGF), basic fibroblast growth factors (bFGF) and TGF-beta(1), endothelial nitric oxide synthase (eNOS), and anti- and pro-apoptotic markers.
Transcription (expressions) of bFGF in fibroblast
1) Confidence 0.65 Published 2002 Journal Diabetologia Section Body Doc Link 11914746 Disease Relevance 0.09 Pain Relevance 0
RESULTS—VEGF and bFGF mRNA expression were significantly increased in MSC-injected thigh muscles of STZ-induced diabetic rats.
Transcription (expression) of bFGF in muscles associated with diabetes mellitus
2) Confidence 0.61 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2570407 Disease Relevance 0.63 Pain Relevance 0.24
bFGF and VEGF mRNA expressions in MSC-injected thigh muscles of 12-week STZ-induced diabetic rats significantly increased by 1.79- and 1.62-fold, respectively, compared with those in saline-injected thigh muscles (Fig. 2).
Transcription (expressions) of bFGF in thigh associated with diabetes mellitus
3) Confidence 0.61 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.49 Pain Relevance 0.10
In our study, bFGF and VEGF mRNA expressions in STZ-induced diabetic rats were upregulated in MSC-injected hind limb muscles, and MSCs maintained their viabilities and abilities to secrete bFGF and VEGF even 4 weeks after the transplantation.
Transcription (expressions) of bFGF in limb muscles associated with diabetes mellitus
4) Confidence 0.59 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.26 Pain Relevance 0.15
Fgf2 protein and mRNA expression were not normalized by insulin treatment, with levels remaining significantly elevated compared to controls (Figure 7).
Transcription (expression) of Fgf2
5) Confidence 0.58 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.23 Pain Relevance 0
We observed significantly higher mRNA levels for VEGF (1.73-fold), FGF-2 (5.6-fold) and TGFbeta receptor III (2.93-fold), PDGF receptor alpha (2.93-fold) and receptor beta (2.91-fold) in rats receiving indomethacin compared to rats given placebo (p < 0.05).
Transcription (levels) of FGF-2
6) Confidence 0.50 Published 2007 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 17440234 Disease Relevance 0.27 Pain Relevance 0.18
Our data agree with a previous report of upregulated Fgf2 protein levels after 3 months of diabetes in the Sprague Dawley rat [54].
Transcription (levels) of Fgf2 associated with diabetes mellitus
7) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.65 Pain Relevance 0.07
Previously a sustained induction of Fgf2 mRNA levels in spite of insulin treatment at a one month time point has been reported [55].
Transcription (levels) of Fgf2
8) Confidence 0.43 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.70 Pain Relevance 0.04
Over-expression SDF-1 in AdV.SDF-1 group increased the expression of VEGF and bFGF mRNA analyzed in the myocardium infarction area (Fig. 4) after MI, and VEGF and bFGF expression increased obviously in 3 day after MI and continued until 7–28 days after MI.Fig. 4SYBR Green real-time PCR analysis of TGF-?
Spec (analyzed) Transcription (analyzed) of bFGF in myocardium associated with infarction and myocardial infarction
9) Confidence 0.22 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.39 Pain Relevance 0
1 in infarcted (a) and noninfarcted (b) myocardium, and of collagen type I (c), type III (d), bFGF (e) and VEGF (f) mRNA expression in infarcted myocardium.
Transcription (expression) of bFGF in myocardium
10) Confidence 0.22 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.37 Pain Relevance 0
Over-expression SDF-1 in AdV.SDF-1 group increased the expression of VEGF and bFGF mRNA analyzed in the myocardium infarction area (Fig. 4) after MI, and VEGF and bFGF expression increased obviously in 3 day after MI and continued until 7–28 days after MI.Fig. 4SYBR Green real-time PCR analysis of TGF-?
Transcription (expression) of bFGF in myocardium associated with infarction and myocardial infarction
11) Confidence 0.22 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.38 Pain Relevance 0
Two patterns of expression were evident with one set of proteins regulated at both the transcript and protein levels (Cp, Lgals3, Fgf2, and Stat3) (Figure 5) and another set with altered protein expression but no significant changes in transcript expression (Cryaa, Cryab, Cryba3, Crybb2, Dbi, and Anxa5) (Figure 6).
Transcription (transcript) of Fgf2
12) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0 Pain Relevance 0

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