INT101889

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.61
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (DSP) structural molecule activity (DSP) plasma membrane (DSP)
protein binding, bridging (DSP) cytoplasm (DSP)
DSP (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 9 98.32 Very High Very High Very High
Pain 5 96.64 Very High Very High Very High
addiction 6 94.16 High High
pain pelvic 1 90.80 High High
transdermal 1 85.20 High High
Dismenorea 6 75.00 Quite High
backache 1 69.20 Quite High
headache 3 65.76 Quite High
cINOD 2 53.24 Quite High
Kinase C 39 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 1 96.64 Very High Very High Very High
Bullous Skin Disease 912 94.64 High High
Adhesions 153 94.04 High High
Reprotox - General 3 1 90.80 High High
Cramps 1 79.20 Quite High
Reprotox - General 1 5 75.00 Quite High
Acantholysis 195 73.48 Quite High
Low Back Pain 1 69.52 Quite High
Headache 2 65.76 Quite High
INFLAMMATION 24 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, plakoglobin regulates the turn over of desmosomal components because the protein levels of desmogleins as well as of plakoglobin and desmoplakin were decreased in plakoglobin-deficient cells (Yin et al. 2005).
Negative_regulation (decreased) of desmoplakin
1) Confidence 0.42 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.57 Pain Relevance 0
This can be concluded from experiments in which expression of N-terminally deleted Dsc 3 or desmoplakin deficiency resulted in impaired formation of both desmosomes and adherens junctions (Hanakawa et al. 2000; Vasioukhin et al. 2001).


Negative_regulation (deficiency) of desmoplakin
2) Confidence 0.42 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.07 Pain Relevance 0.05
After 24 h, Dsg 3 but not Dsg 2, plakoglobin or desmoplakin was also depleted from the cytoskeletal fractions leading to reduced total cellular Dsg 3 levels (Calkins et al. 2006; Yamamoto et al. 2007a).
Negative_regulation (depleted) of desmoplakin
3) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.24 Pain Relevance 0
Both treatments significantly reduced DPI by the 30th minute (GTN, -12.8 +/- 17.9; DCF, -18.9 +/- 16.6).
Negative_regulation (reduced) of DPI associated with diclofenac
4) Confidence 0.09 Published 2002 Journal Gynecol. Endocrinol. Section Abstract Doc Link 11915580 Disease Relevance 0.72 Pain Relevance 1.00
An inhibitor of NADPH oxidase, diphenylene iodonium (DPI, 20 ?
Negative_regulation (inhibitor) of DPI
5) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1574293 Disease Relevance 0 Pain Relevance 0

General Comments

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