INT10189

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Context Info
Confidence 0.32
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 8.05
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T-cell 6
bone marrow 2
head 2
optic 2
mast cells 2
Il2ra (Mus musculus)
Pain Link Frequency Relevance Heat
depression 11 99.00 Very High Very High Very High
Neuritis 5 98.36 Very High Very High Very High
Central grey 10 98.18 Very High Very High Very High
Morphine 12 97.96 Very High Very High Very High
cytokine 25 97.64 Very High Very High Very High
Cannabinoid receptor 1 97.44 Very High Very High Very High
Inflammation 74 97.28 Very High Very High Very High
Demyelination 1 95.72 Very High Very High Very High
analgesia 1 94.52 High High
spastic colon 1 90.16 High High
Disease Link Frequency Relevance Heat
Systemic Mastocytosis 53 99.90 Very High Very High Very High
Depression 13 99.00 Very High Very High Very High
Optic Neuritis 5 98.60 Very High Very High Very High
Brain Injury 21 98.32 Very High Very High Very High
Urological Neuroanatomy 19 98.18 Very High Very High Very High
INFLAMMATION 79 97.28 Very High Very High Very High
Cancer 2 95.84 Very High Very High Very High
Demyelinating Disease 1 95.72 Very High Very High Very High
Necrosis 5 95.36 Very High Very High Very High
Gastroenteritis 1 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mucosal mast cells were quantitated, and the presence or absence of CD25 expression on mast cells was determined.
Negative_regulation (absence) of Gene_expression (expression) of CD25 in mast cells
1) Confidence 0.32 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 18059223 Disease Relevance 2.30 Pain Relevance 0.23
In vivo depletion of CD4+ CD25+ population
Negative_regulation (depletion) of Gene_expression (population) of CD25
2) Confidence 0.18 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 0.54 Pain Relevance 0
Minor criteria for a diagnosis of SM can include abnormal mast cell morphologies in the bone marrow and other extracutaneous organs, mutation of the tyrosine kinase KIT at codon 816, expression of CD2 and/or CD25 by bone marrow mast cells, and a serum tryptase level >20 ng/mL.
Negative_regulation (include) of Gene_expression (expression) of CD25 in bone marrow associated with systemic mastocytosis
3) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2386235 Disease Relevance 2.26 Pain Relevance 0.12
These results suggested that injection of morphine in the PAG suppresses NK and T cell functions by reducing the ability of T cells to produce IL-2 and downregulating the expression of CD25 and CD71 surface activation markers.
Negative_regulation (downregulating) of Gene_expression (expression) of CD25 in T cell associated with central grey and morphine
4) Confidence 0.08 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.44 Pain Relevance 0.65
Furthermore, morphine did not alter the expression of CD3, CD4, CD8, and NKR-P1 surface markers, but significantly (p < 0.001) downregulated the expression of CD25 and CD71 receptors following in vitro activation.
Negative_regulation (downregulated) of Gene_expression (expression) of CD25 in CD3 associated with morphine
5) Confidence 0.06 Published 1999 Journal J. Interferon Cytokine Res. Section Abstract Doc Link 10433363 Disease Relevance 0.38 Pain Relevance 0.70
It has been shown that decreased production of interleukin-2 (IL-2) and expression of the surface IL-2 receptor alpha chain (CD25) is associated with immune depression in head injury.
Negative_regulation (decreased) of Gene_expression (expression) of CD25 in head associated with depression and brain injury
6) Confidence 0.04 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 1.08 Pain Relevance 0.33
Evaluation of IL-2, sIL2R, IL-6, TNF-alpha, and IL-1 beta levels in serum and CSF of patients with optic neuritis.
Negative_regulation (Evaluation) of Gene_expression (levels) of sIL2R in optic associated with optic neuritis and neuritis
7) Confidence 0.01 Published 1992 Journal J. Neurol. Sci. Section Title Doc Link 1469455 Disease Relevance 0.68 Pain Relevance 0.59
Here, we show that arvanil inhibits early events in T-cell receptor (TCR)-mediated T-cell activation, such as calcium mobilization and nuclear factor of activated T-cell activation, and in late events in TCR-mediated activation, such as interleukin (IL)-2 gene transcription, IL-2R expression, and cell-cycle progression.
Negative_regulation (inhibits) of Gene_expression (expression) of IL-2R in T-cell
8) Confidence 0.00 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16394182 Disease Relevance 0.36 Pain Relevance 0.30

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