INT101891

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Context Info
Confidence 0.58
First Reported 1999
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 25
Total Number 32
Disease Relevance 24.09
Pain Relevance 9.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (Cftr) enzyme binding (Cftr) molecular_function (Cftr)
protein complex (Cftr) transmembrane transport (Cftr) cytoplasm (Cftr)
Anatomy Link Frequency
epithelial cells 3
pancreas 2
myocytes 1
photoreceptor 1
sinus 1
Cftr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 444 100.00 Very High Very High Very High
Inflammatory response 19 99.92 Very High Very High Very High
Serotonin 1 99.12 Very High Very High Very High
Chronic pancreatitis 98 98.96 Very High Very High Very High
Inflammatory mediators 2 98.04 Very High Very High Very High
fluoxetine 5 97.92 Very High Very High Very High
Prostatitis 476 97.00 Very High Very High Very High
Pain 13 93.44 High High
alcohol 5 90.92 High High
isoflurane 4 89.20 High High
Disease Link Frequency Relevance Heat
Cystic Fibrosis 442 100.00 Very High Very High Very High
INFLAMMATION 259 99.56 Very High Very High Very High
Pancreatitis 149 99.24 Very High Very High Very High
Duodenal Ulcer 20 99.12 Very High Very High Very High
Disease 136 98.96 Very High Very High Very High
Sinusitis 42 98.88 Very High Very High Very High
Exocrine Pancreatic Insufficiency 12 97.84 Very High Very High Very High
Pressure And Volume Under Development 81 97.52 Very High Very High Very High
Prostatitis 476 97.00 Very High Very High Very High
Pulmonary Disease 47 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is clear from these atypical presentations of CFTR dysfunction that it is the vas deferens, pancreas, and sinuses that are the tissues most sensitive to decreases in CFTR function.
Negative_regulation (decreases) of CFTR in vas deferens
1) Confidence 0.58 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 0.90 Pain Relevance 0.23
Some mutations cause relatively mild reductions in CFTR function and may lead to disease in one organ without clinical involvement of other organs.
Negative_regulation (reductions) of CFTR associated with disease
2) Confidence 0.58 Published 1999 Journal Curr. Opin. Gastroenterol. Section Abstract Doc Link 17023980 Disease Relevance 1.00 Pain Relevance 0.64
Defects in the CFTR gene cause abnormal chloride conductance across the apical membrane of epithelial cells, which results in progressive lung disease and also affects other organs.
Negative_regulation (Defects) of CFTR gene in lung associated with pulmonary disease
3) Confidence 0.43 Published 2006 Journal An Pediatr (Barc) Section Abstract Doc Link 16948978 Disease Relevance 0.93 Pain Relevance 0.34
A novel small molecule CFTR inhibitor attenuates HCO3- secretion and duodenal ulcer formation in rats.
Negative_regulation (inhibitor) of CFTR associated with duodenal ulcer
4) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Title Doc Link 15905414 Disease Relevance 0.95 Pain Relevance 0.37
To further test this hypothesis, we examined the effect of a novel, potent, and highly selective CFTR inhibitor, CFTR(inh)-172, on DBS and duodenal ulceration in rats.
Negative_regulation (inhibitor) of CFTR associated with duodenal ulcer
5) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.94 Pain Relevance 0.38
CFTR inhibition reduces acid-induced DBS but also prevents duodenal ulcer formation, supporting our hypothesis that intracellular HCO(3)(-) may be an important protective mechanism for duodenal epithelial cells.
Negative_regulation (inhibition) of CFTR in epithelial cells associated with duodenal ulcer
6) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.61 Pain Relevance 0.16
To further test this hypothesis, we examined the effect of a novel, potent, and highly selective CFTR inhibitor, CFTR(inh)-172, on DBS and duodenal ulceration in rats.
Negative_regulation (inhibitor) of CFTR associated with duodenal ulcer
7) Confidence 0.43 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15905414 Disease Relevance 0.94 Pain Relevance 0.38
The manifestation of CFTR dysfunction in the pancreas is determined by the degree of decrease in CFTR levels, with a decrease to 10% of normal leading to an increased risk for pancreatitis, and a decrease to levels less than 1% leading invariably to exocrine pancreatic insufficiency.
Negative_regulation (decrease) of CFTR in pancreas associated with exocrine pancreatic insufficiency and pancreatitis
8) Confidence 0.43 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 0.85 Pain Relevance 0.08
The evidence is mounting that a moderate decrease in CFTR function can lead to isolated sinus disease.
Negative_regulation (decrease) of CFTR in sinus associated with disease
9) Confidence 0.43 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.32 Pain Relevance 0.15
The third group of patients that give us insight into tissue sensitivity to decreases in CFTR function are patients with chronic sinusitis and polyposis.
Negative_regulation (decreases) of CFTR associated with sinusitis
10) Confidence 0.43 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.27 Pain Relevance 0.17
Further research is needed to determine whether the CFTR deficiency leads directly to pancreatitis or whether it increases the risk of pancreatitis only after exposure to stressors [19].
Spec (whether) Negative_regulation (deficiency) of CFTR associated with pancreatitis
11) Confidence 0.43 Published 2000 Journal Respir Res Section Body Doc Link PMC59552 Disease Relevance 1.12 Pain Relevance 0.13
Depending on the molecular abnormality, the defect in CFTR may be the equivalent of that associated with a 'null' mutation, or may be 'mild', with partial/residual function [4].
Negative_regulation (defect) of CFTR
12) Confidence 0.43 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 0.80 Pain Relevance 0.30
This efficiency decreases with shorter polythymidine tracts (5T and 7T), which results in a lower than normal level of full-length CFTR mRNA and presumably in a decrease in mature, functional CFTR protein.
Negative_regulation (decrease) of CFTR
13) Confidence 0.42 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 0.46 Pain Relevance 0.17
A rigorous search was conducted for other mutations in patients with one CFTR mutation, and CFTR function in nasal epithelia was assessed in vivo in patients with ICP [17].
Negative_regulation (assessed) of CFTR in nasal associated with chronic pancreatitis
14) Confidence 0.42 Published 2001 Journal Respir Res Section Body Doc Link PMC64805 Disease Relevance 1.53 Pain Relevance 1.07
secretion since inhibitor of either CFTR or CAII greatly attenuates bacterial killing by both the primary prostatic epithelial culture and rat prostate.
Negative_regulation (inhibitor) of CFTR
15) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.71 Pain Relevance 0.24
Defects in CFTR are associated with increased production of pro-inflammatory mediators including IL-8, a potent neutrophil chemoattractant that stimulates the influx of massive numbers of neutrophils into the airways.
Negative_regulation (Defects) of CFTR in neutrophil associated with inflammatory mediators
16) Confidence 0.32 Published 2002 Journal Clin Rev Allergy Immunol Section Abstract Doc Link 12162106 Disease Relevance 1.70 Pain Relevance 0.58
When 1×105 CFU E.coli were added to the cells in the absence or presence of CFTR inhibitor, CFTRinh-172 (10 µM) or CFTR antibody, we observed significantly larger number of bacterial colonies in the medium collected from the CFTRinh-172 and CFTR antibody treatment groups as compared to the non-treated control group (Figure 4A, B).
Negative_regulation (inhibitor) of CFTR
17) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.51 Pain Relevance 0.25
When 1×105 CFU E.coli were added to the cells in the absence or presence of CFTR inhibitor, CFTRinh-172 (10 µM) or CFTR antibody, we observed significantly larger number of bacterial colonies in the medium collected from the CFTRinh-172 and CFTR antibody treatment groups as compared to the non-treated control group (Figure 4A, B).
Negative_regulation (inhibitor) of CFTR
18) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.51 Pain Relevance 0.25
The forskolin-induced pHi recovery could be blocked by NPPB (100 µM) (Figure 2D), a blocker known to inhibit CFTR, suggesting that CFTR may be responsible for the HCO3?
Negative_regulation (inhibit) of CFTR
19) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.13 Pain Relevance 0.10
For blocking of CFTR or carbonic anhydrase, the E coli treated epithelial cells were preincubated with 10 µM CFTRinh-172 (Sigma), a specific CFTR channel blocker or anti-CFTR antibody (1?
Negative_regulation (blocking) of CFTR in epithelial cells
20) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.18 Pain Relevance 0

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