INT101902

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.92
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Mki67) nucleolus (Mki67) nucleus (Mki67)
intracellular (Mki67) cytoplasm (Mki67)
Anatomy Link Frequency
embryos 1
fundus 1
endometrium 1
Mki67 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 1 83.12 Quite High
methotrexate 5 83.00 Quite High
Inflammation 37 79.08 Quite High
positron emission tomography 59 76.96 Quite High
cytokine 4 75.84 Quite High
palliative 4 72.84 Quite High
COX2 1 25.00 Low Low
imagery 38 21.76 Low Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 216 99.96 Very High Very High Very High
Cancer 522 98.96 Very High Very High Very High
Apoptosis 105 98.96 Very High Very High Very High
Malignant Neoplastic Disease 15 98.30 Very High Very High Very High
Infection 43 96.72 Very High Very High Very High
Triple Negative Breast Cancer 30 95.16 Very High Very High Very High
Lymphatic System Cancer 15 93.76 High High
Endometrial Cancer 2 93.12 High High
Cirrhosis 4 92.40 High High
Immunization 1 92.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Ki67 mRNA levels did not decrease as much as 18F-FLT uptake 6 hours after treatment initiation.
Neg (not) Negative_regulation (decrease) of Ki67
1) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2945761 Disease Relevance 0.13 Pain Relevance 0.06
Loss of the epiblast in defective embryos appeared to be a consequence of decreased cell proliferation, as determined by a marked reduction of Ki67 immunostaining.
Spec (determined) Negative_regulation (reduction) of Ki67 in embryos
2) Confidence 0.31 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2865459 Disease Relevance 0.10 Pain Relevance 0
Another interesting observation during this study was that at 21 days, a decrease in Ki-67 and Caspase-3 was predictive of favorable response (p = 0.01 for both).
Negative_regulation (decrease) of Ki-67
3) Confidence 0.28 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2669088 Disease Relevance 0.66 Pain Relevance 0
Mice treated with RAPA/BEV showed the most dramatic decrease in Ki-67 (cell proliferation) when compared to vehicle control mice.
Negative_regulation (decrease) of Ki-67
4) Confidence 0.28 Published 2009 Journal Mol Imaging Biol Section Body Doc Link PMC2719751 Disease Relevance 0.89 Pain Relevance 0
Good responders had significantly higher Ki-67 and significantly lower Bcl-2 at baseline and a significant decrease in Ki-67 and Caspase-3 at 21 days after the first chemotherapy.


Negative_regulation (decrease) of Ki-67
5) Confidence 0.21 Published 2009 Journal World J Surg Oncol Section Abstract Doc Link PMC2669088 Disease Relevance 0.21 Pain Relevance 0
Further follow up showed that this decrease in Ki-67 after 10–21 days of therapy had a significant association with good clinical response on univariate analysis [15].
Negative_regulation (decrease) of Ki-67
6) Confidence 0.18 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2669088 Disease Relevance 0.31 Pain Relevance 0.04
Ki67 is vital for cell proliferation, since downregulation of Ki67 using antisense nucleotides prevents cell proliferation.10 Ki67 is tightly controlled and regulated, implying a fundamental role in cell proliferation.
Negative_regulation (downregulation) of Ki67
7) Confidence 0.17 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.70 Pain Relevance 0
Low histologic grade, positive hormone receptors, positive bcl-2 and low level of Ki-67 were associated with prolonged RFS.
Negative_regulation (level) of Ki-67
8) Confidence 0.16 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2217558 Disease Relevance 0.55 Pain Relevance 0
In other published studies using non-anthracycline based chemoendocrine agents [11], it was reported that positive ER, absence of c-erbB2 and decrease in Ki-67 were associated with a good clinical response.
Negative_regulation (decrease) of Ki-67
9) Confidence 0.16 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2217558 Disease Relevance 0.34 Pain Relevance 0.07
PTTG1 siRNA was successful in downregulating PTTG1 as well as Ki67, bFGF, and CD34 in H1299 tumors in nude mice.
Negative_regulation (downregulating) of Ki67 associated with cancer
10) Confidence 0.16 Published 2008 Journal J Ovarian Res Section Body Doc Link PMC2584053 Disease Relevance 0.67 Pain Relevance 0
In human breast cancer, reduced Ki-67 staining is seen after treatment with SERMs and aromatase inhibitors and has been used as efficacy marker in antiestrogen therapy [24].
Negative_regulation (reduced) of Ki-67 associated with breast cancer
11) Confidence 0.14 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.53 Pain Relevance 0
The purpose of this study was to evaluate expression of COX-2 in benign and malignant endometrium in the context of other cell cycle and proliferation markers, including Ki-67, cyclin D1, and the cyclin-dependent kinase inhibitor, p21.
Negative_regulation (inhibitor) of Ki-67 in endometrium associated with malignant neoplastic disease
12) Confidence 0.04 Published 2002 Journal Int. J. Gynecol. Pathol. Section Abstract Doc Link 11917224 Disease Relevance 1.03 Pain Relevance 0.16
Higher numbers of Ki67-positive, and thus proliferating epithelial cells were seen at 9 weeks and 8 months after infection in both fundus and antrum of H. suis-infected BALB/c mice, compared to control animals.
Negative_regulation (numbers) of Ki67-positive in fundus associated with infection
13) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2989923 Disease Relevance 0.81 Pain Relevance 0

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