INT101912

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 5.55
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
Anatomy Link Frequency
blood 1
plasma 1
joint 1
bladder 1
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 228 100.00 Very High Very High Very High
rheumatoid arthritis 126 97.76 Very High Very High Very High
Arthritis 10 97.64 Very High Very High Very High
Osteoarthritis 56 91.40 High High
cytokine 6 68.88 Quite High
cINOD 3 66.04 Quite High
Inflammatory response 1 61.68 Quite High
Inflammatory mediators 2 45.64 Quite Low
Inflammation 17 45.04 Quite Low
methotrexate 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Overweight 13 99.04 Very High Very High Very High
Transitional Cell Carcinoma 78 98.00 Very High Very High Very High
Rheumatoid Arthritis 126 97.76 Very High Very High Very High
Arthritis 11 97.64 Very High Very High Very High
Obesity 104 97.08 Very High Very High Very High
Pancreatic Cancer 1 93.20 High High
Osteogenic Sarcomas 1 92.52 High High
Melanoma 73 91.76 High High
Osteoarthritis 56 91.40 High High
Malignant Neoplastic Disease 12 90.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of p38MAPK by the specific inhibitor SB203580 resulted in downregulation of MMP-2 mRNA and protein levels as well as gelatinolytic activity, while expression levels of TIMP-1 and TIMP-2 mRNAs were not changed.
Regulation (changed) of TIMP-2 associated with metalloproteinase
1) Confidence 0.44 Published 2002 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11918086 Disease Relevance 0.64 Pain Relevance 0.63
Importantly, the IgG fraction containing TIMP antibodies down-regulated the TIMP-2 inhibitory effect, thereby supporting MMP9 activity in vitro.
Regulation (regulated) of TIMP-2
2) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1257425 Disease Relevance 0.64 Pain Relevance 0.40
The attenuation of TIMP-2 functions in the presence of anti-TIMP-2 antibodies in RA patients may be one of the steps in the mechanism preventing joint destruction.
Regulation (attenuation) of TIMP-2 in joint associated with rheumatoid arthritis
3) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257425 Disease Relevance 0.46 Pain Relevance 0.26
The plasma concentration of MMP2 was significantly higher in comparison to the control group whereas the concentrations of MMP1, TIMP1, TIMP2, and MTC1 were significantly lower from patients with non-metastasized TCC of the bladder in comparison to the healthy control group (Table I).
Regulation (concentrations) of TIMP2 in bladder associated with transitional cell carcinoma
4) Confidence 0.23 Published 2006 Journal BMC Urol Section Body Doc Link PMC1560390 Disease Relevance 0.64 Pain Relevance 0.19
The concentrations of TIMP1, TIMP2, and MTC1 in plasma probes were significantly lower from patients with non-metastasized TCC compared to the controls.
Regulation (concentrations) of TIMP2 in plasma
5) Confidence 0.23 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1560390 Disease Relevance 0.35 Pain Relevance 0.03
In this study the concentrations of MMP1, MMP2, MMP3, MMP9, their inhibitors TIMP1, TIMP2, and the MMP1/TIMP1-complex (MTC1) were quantified in blood plasma with the sandwich enzyme-linked immunosorbent assay (ELISA).
Regulation (concentrations) of TIMP2 in blood
6) Confidence 0.23 Published 2006 Journal BMC Urol Section Abstract Doc Link PMC1560390 Disease Relevance 0.44 Pain Relevance 0.13
However, this up-regulation of TIMP-2 was found in normal or overweight patients only, and decreased when the BMI of the patients increased.
Regulation (regulation) of TIMP-2 associated with obesity and overweight
7) Confidence 0.21 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.99 Pain Relevance 0.22
TIMP2 is involved in matrix degradation and invasion, and is down-regulated in Motif 1 cell lines in this study, which is consistent with its role in inhibiting matrix metalloproteinases, and agrees with the inverse correlation shown between S100A4 and TIMP2 in osteosarcoma cells [31].
Regulation (regulated) of TIMP2 associated with metalloproteinase and osteogenic sarcomas
8) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 1.38 Pain Relevance 0.15

General Comments

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