INT101913

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.20
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TIMP2)
TIMP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 21 100.00 Very High Very High Very High
cINOD 1 67.32 Quite High
cytokine 2 65.88 Quite High
Inflammatory response 2 62.96 Quite High
psoriasis 1 58.76 Quite High
Inflammation 3 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Piles 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 17 86.40 High High
Skin Cancer 3 76.16 Quite High
INFLAMMATION 6 67.08 Quite High
Wound Healing 18 60.80 Quite High
Malignant Neoplastic Disease 2 60.60 Quite High
Eczema 1 59.36 Quite High
Psoriasis 1 58.76 Quite High
Cancer 1 55.80 Quite High
Aging 4 55.36 Quite High
Skin Diseases 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of p38MAPK by the specific inhibitor SB203580 resulted in downregulation of MMP-2 mRNA and protein levels as well as gelatinolytic activity, while expression levels of TIMP-1 and TIMP-2 mRNAs were not changed.
Regulation (changed) of Gene_expression (expression) of TIMP-2 associated with metalloproteinase
1) Confidence 0.44 Published 2002 Journal Clin. Exp. Metastasis Section Abstract Doc Link 11918086 Disease Relevance 0.65 Pain Relevance 0.63
While MMP activity is altered by the O3, neither TIMP-1 nor TIMP-2 level expression is affected.
Neg (neither) Regulation (affected) of Gene_expression (expression) of TIMP-2
2) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2910505 Disease Relevance 0.56 Pain Relevance 0.29

General Comments

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