INT101923

Context Info Confidence 0.48 First Reported 2002 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 6 Total Number 6 Disease Relevance 5.44 Pain Relevance 0.71

extracellular space (MICA) plasma membrane (MICA) cytoplasm (MICA)

Anatomy Link Frequency skin 3 epithelial cells 1 MICA (Homo sapiens)

Pain Link Frequency Relevance Heat psoriasis 51 98.92 Arthritis 89 95.08 melanocortin 1 receptor 3 93.68 rheumatoid arthritis 11 88.24 Inflammation 18 81.76 Crohn's disease 1 44.24 fibrosis 1 5.76 agonist 3 5.00 corticosteroid 2 5.00 cINOD 2 5.00

Disease Link Frequency Relevance Heat Skin Cancer 48 99.12 Psoriasis 51 98.92 Mrsa Infection 4 97.20 Seronegative Spondarthritis 73 95.08 Genetic Predisposition To Disease 5 91.64 Rheumatoid Arthritis 11 88.24 Papillomavirus Infection 9 87.52 Stress 9 87.44 Staphylococcus Infection 1 86.88 Pulmonary Disease 87 86.60

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To evaluate the possible association of MICA gene polymorphism with the risk for nonmelanoma skin cancer we evaluated 153 cases with squamous cell carcinoma, 261 cases with basal cell carcinoma, 111 controls with malignant melanoma, and 247 controls without a history of skin cancer.

MICA gene Binding (association) of in skin associated with skin cancer

1) Confidence 0.48 Published 2002 Journal J. Invest. Dermatol. Section Abstract Doc Link 11918717 Disease Relevance 0.73 Pain Relevance 0

We therefore specifically addressed the possible association between MICA 5.1 homozygosity and skin cancer, as these individuals are expected to be at the highest risk for skin cancer if the MICA gene plays a role in skin carcinogenesis.

MICA Binding (association) of in skin associated with skin cancer

2) Confidence 0.37 Published 2002 Journal J. Invest. Dermatol. Section Abstract Doc Link 11918717 Disease Relevance 1.14 Pain Relevance 0

Therefore, we conclude that an association between MICA gene polymorphism and nonmelanoma skin cancer is not likely.

MICA gene Binding (association) of in skin associated with skin cancer

3) Confidence 0.33 Published 2002 Journal J. Invest. Dermatol. Section Abstract Doc Link 11918717 Disease Relevance 1.00 Pain Relevance 0.09

Association with 2 genes, MICA and the TNF-?

MICA Binding (Association) of

4) Confidence 0.28 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128931 Disease Relevance 1.63 Pain Relevance 0.62

The activating function of NKG2 D is triggered by binding to MHC class 1 chain-related (MIC) molecules A and B, expressed on surface of stressed epithelial cells.

MHC class 1 chain-related Binding (binding) of in epithelial cells

5) Confidence 0.13 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2955660 Disease Relevance 0.68 Pain Relevance 0

In each instance, besifloxacin had the highest AUC0–24 h:MIC90 ratio for all Staphylococcus organisms.

MIC90 Binding (ratio) of

6) Confidence 0.05 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2861941 Disease Relevance 0.26 Pain Relevance 0

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