INT101925

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 1.82
Pain Relevance 4.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
fibroblast 2
brain 1
nucleus 1
hippocampus 1
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 333 100.00 Very High Very High Very High
Ventral tegmentum 14 98.80 Very High Very High Very High
agonist 88 98.64 Very High Very High Very High
Eae 8 97.92 Very High Very High Very High
Nucleus accumbens 17 97.84 Very High Very High Very High
dopamine receptor 25 97.60 Very High Very High Very High
Hippocampus 71 97.20 Very High Very High Very High
antagonist 63 96.88 Very High Very High Very High
cocaine 5 95.96 Very High Very High Very High
opioid receptor 3 94.80 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 14 99.04 Very High Very High Very High
Disease 41 97.60 Very High Very High Very High
Restless Legs Syndrome 89 97.38 Very High Very High Very High
Anaemia 5 71.08 Quite High
Sprains And Strains 171 65.48 Quite High
Hypoxia 24 62.76 Quite High
Movement Disorders 9 55.68 Quite High
Sleep Disorders 13 50.00 Quite Low
Anxiety Disorder 8 49.72 Quite Low
Parkinson's Disease 3 41.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was no difference in dopamine D1 receptor binding, whereas dopamine D2 receptor binding was significantly lower in the hippocampus of deficient animals.
dopamine D1 receptor Binding (binding) of in hippocampus associated with dopamine and hippocampus
1) Confidence 0.43 Published 2002 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11919654 Disease Relevance 0 Pain Relevance 0.66
Ginés et al. [50] described the formation of functionally interacting heteromeric complexes between dopamine D1 receptors (D1Rs) and A1Rs in mouse fibroblast Ltk?
D1R Binding (interacting) of in fibroblast associated with dopamine
2) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.25 Pain Relevance 0.53
Ginés et al. [50] described the formation of functionally interacting heteromeric complexes between dopamine D1 receptors (D1Rs) and A1Rs in mouse fibroblast Ltk?
D1R Binding (complexes) of in fibroblast associated with dopamine
3) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.24 Pain Relevance 0.52
The results confirmed an antagonistic interaction between A1Rs and D1Rs that had already been observed by Ferré et al. [51] in behavioral studies using reserpinized mice and rabbits.
D1R Binding (interaction) of
4) Confidence 0.36 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072922 Disease Relevance 0.21 Pain Relevance 0.52
The D1R can bind to either the inactive G protein first, and then dopamine, or dopamine first and then the inactive G protein [85–87].
D1R Binding (bind) of associated with dopamine
5) Confidence 0.35 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1562452 Disease Relevance 0 Pain Relevance 0.32
Real-time polymerase chain reaction was performed as duplicate determinations with specific Taqman probes from the mouse Probe Library (Exiqon A/S, Vedbaek, Denmark) designed for primers to mouse DRD1 (F: 5?
DRD1 Binding (primers) of
6) Confidence 0.31 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.07
Linkage of DRD1 and DRD2 binding was sex-specific and only detected in males.
DRD1 Binding (Linkage) of
7) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.12 Pain Relevance 0.37
As expected, dopaminergic systems are clearly downstream of Comt, including Maoa in the striatum, DRD1 and DRD2 binding density in multiple brain regions, and the response to the dopamine receptor antagonist haloperidol.
DRD1 Binding (binding) of in brain associated with antagonist and dopamine receptor
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.07 Pain Relevance 0.44
Linkage of DRD1 and DRD2 binding was sex-specific and only detected in males.
DRD1 Binding (binding) of
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.12 Pain Relevance 0.37
After repeated METH exposure, striatal and nucleus accumbal dopamine D1 receptor binding was decreased in mu-OR knockout mice but was not changed in wild-type mice.
D1 receptor Binding (binding) of in nucleus associated with targeted disruption and dopamine
10) Confidence 0.16 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17139685 Disease Relevance 0.36 Pain Relevance 0.63
Ropinirole was the first FDA-approved pharmacological agent for moderate to severe primary RLS.72 Ropinirole is classified as a non-ergolide dopamine agonist, and has affinity for the D2 and D3 receptor subtypes, but minimal affinity for the D1 receptor subtype.
D1 receptor Binding (affinity) of associated with dopamine, agonist and restless legs syndrome
11) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857615 Disease Relevance 0.46 Pain Relevance 0.55

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