INT101937

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Context Info
Confidence 0.19
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.21
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
RAW 264 2
nucleus 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 12 97.16 Very High Very High Very High
Migraine 5 96.08 Very High Very High Very High
withdrawal 9 94.84 High High
Morphine 6 94.40 High High
agonist 1 86.40 High High
antagonist 1 85.28 High High
Cannabinoid receptor 1 81.12 Quite High
analgesia 1 78.20 Quite High
headache 2 73.08 Quite High
Analgesic 3 70.80 Quite High
Disease Link Frequency Relevance Heat
Necrosis 4 98.46 Very High Very High Very High
Cancer 4 98.28 Very High Very High Very High
INFLAMMATION 13 97.16 Very High Very High Very High
Headache 7 96.08 Very High Very High Very High
Nociception 3 90.56 High High
Sinusitis 1 73.96 Quite High
Toothache 1 73.52 Quite High
Erythema 1 72.68 Quite High
Acne 1 72.28 Quite High
Pressure And Volume Under Development 2 68.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, MEIO inhibited the LPS-induced DNA binding activity of nuclear factor-kappaB (NF-kappaB), and this was associated with the prevention of inhibitor kappaB degradation and a reduction in nuclear p65 protein levels.
Negative_regulation (prevention) of Protein_catabolism (degradation) of NF-kappaB
1) Confidence 0.19 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.95 Pain Relevance 0.22
Arvanil also prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activation by direct inhibition of IkappaBalpha degradation, NF-kappaB binding to DNA, and NF-kappaB-dependent transcription.
Negative_regulation (inhibition) of Protein_catabolism (degradation) of NF-kappaB associated with necrosis and cancer
2) Confidence 0.12 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16394182 Disease Relevance 0.42 Pain Relevance 0.31
Furthermore, EAAD suppressed LPS-induced phosphorylation of p38 MAPK and extracellular-signal regulated kinases 1/2 (ERK1/2), I-kappaBalpha degradation, and NF-kappaB activation in RAW 264.7 cells.
Negative_regulation (suppressed) of Protein_catabolism (degradation) of NF-kappaB in RAW 264
3) Confidence 0.11 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17229575 Disease Relevance 1.07 Pain Relevance 0.27
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Negative_regulation (prevents) of Protein_catabolism (degradation) of IkappaB in nucleus
4) Confidence 0.04 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.83
A Western blot analysis demonstrated that the degradation of IkappaB following TNF-alpha treatment was markedly inhibited by lidocaine.
Negative_regulation (inhibited) of Protein_catabolism (degradation) of IkappaB
5) Confidence 0.04 Published 2010 Journal Immunobiology Section Body Doc Link 19559500 Disease Relevance 0.06 Pain Relevance 0
IkappaBalpha degradation, NF-kappaB activation, and iNOS expression were attenuated by parthenolide (3mg/kg), the active constituent of feverfew, an anti-inflammatory drug used for migraine treatment.
Negative_regulation (attenuated) of Protein_catabolism (degradation) of NF-kappaB associated with inflammation and migraine
6) Confidence 0.03 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.71 Pain Relevance 0.58

General Comments

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