INT10194

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Context Info
Confidence 0.70
First Reported 1989
Last Reported 2011
Negated 14
Speculated 20
Reported most in Abstract
Documents 702
Total Number 723
Disease Relevance 600.62
Pain Relevance 183.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6) aging (IL6) extracellular region (IL6)
Anatomy Link Frequency
plasma 56
CSF 19
blood 14
macrophage 12
brain 10
IL6 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11091 100.00 Very High Very High Very High
cytokine 8723 100.00 Very High Very High Very High
cva 3222 100.00 Very High Very High Very High
Inflammatory response 1113 100.00 Very High Very High Very High
chemokine 961 100.00 Very High Very High Very High
Inflammatory marker 609 100.00 Very High Very High Very High
Inflammatory mediators 505 100.00 Very High Very High Very High
antagonist 335 100.00 Very High Very High Very High
metalloproteinase 264 100.00 Very High Very High Very High
Catecholamine 148 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 13442 100.00 Very High Very High Very High
Disease 5205 100.00 Very High Very High Very High
Cancer 3938 100.00 Very High Very High Very High
Cv General 3 Under Development 3200 100.00 Very High Very High Very High
Stress 2175 100.00 Very High Very High Very High
Infection 1836 100.00 Very High Very High Very High
Coronary Heart Disease 1416 100.00 Very High Very High Very High
Coronary Artery Disease 802 100.00 Very High Very High Very High
Necrosis 758 100.00 Very High Very High Very High
Adhesions 637 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, the researchers have asked whether prolonged moderate increases in the cytokine interleukin-6 (IL-6) in the bloodstream are associated with CHD risk.
Spec (whether) Positive_regulation (increases) of IL-6 associated with coronary heart disease and cytokine
1) Confidence 0.70 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 1.87 Pain Relevance 0.39
When the researchers used this ratio to estimate the impact of prolonged increases in IL-6 levels on CHD, they found that increased long-term IL-6 levels more than doubled the risk for CHD in their study populations.
Positive_regulation (increases) of IL-6 associated with coronary heart disease
2) Confidence 0.70 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 0.89 Pain Relevance 0.09
In this study, the researchers have asked whether prolonged moderate increases in the cytokine interleukin-6 (IL-6) in the bloodstream are associated with CHD risk.
Spec (whether) Positive_regulation (increases) of interleukin-6 associated with coronary heart disease and cytokine
3) Confidence 0.70 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 1.87 Pain Relevance 0.39
These findings indicate prolonged moderate increases in IL-6 levels are associated with risk of CHD as strongly as several major established risk factors, including blood pressure and blood cholesterol levels, but whether there is a cause-and-effect relationship remains unknown.
Spec (whether) Positive_regulation (increases) of IL-6 in blood associated with coronary heart disease
4) Confidence 0.70 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2288623 Disease Relevance 0.73 Pain Relevance 0.03
Small but significant increases in IL-6 were seen at 60 min post-capsaicin.
Positive_regulation (increases) of IL-6 associated with qutenza
5) Confidence 0.70 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 14651947 Disease Relevance 0.71 Pain Relevance 0.57
Serum interleukin-6 (IL-6) concentration was initially elevated, decreased after the start of adrenergic blockade, and gradually fell to an undetectable level after surgery.
Positive_regulation (elevated) of interleukin-6
6) Confidence 0.70 Published 1997 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 9571753 Disease Relevance 1.01 Pain Relevance 0.13
Serum interleukin-6 (IL-6) concentration was initially elevated, decreased after the start of adrenergic blockade, and gradually fell to an undetectable level after surgery.
Positive_regulation (elevated) of IL-6
7) Confidence 0.70 Published 1997 Journal Scand. J. Infect. Dis. Section Abstract Doc Link 9571753 Disease Relevance 1.00 Pain Relevance 0.13
In the present case, elevation of IL-6 was detected, suggesting that IL-6 produced by ATL cells is related to their proliferation in the bone, and local osteolysis.
Positive_regulation (elevation) of IL-6 associated with osteolysis and htlv types i and ii
8) Confidence 0.70 Published 1999 Journal Intern. Med. Section Abstract Doc Link 10526948 Disease Relevance 0.69 Pain Relevance 0.08
These results show that uterine contractions increased the IL-6 concentration in human amniotic fluid, and suggest that uterine contraction enhanced the permeability of the human amniotic cell in vivo.
Positive_regulation (increased) of IL-6 in amniotic fluid associated with dismenorea
9) Confidence 0.70 Published 1995 Journal Nippon Sanka Fujinka Gakkai Zasshi Section Abstract Doc Link 8543847 Disease Relevance 0.18 Pain Relevance 0.10
A significant increase in the level of IL-6 mRNA has been detected in OA-affected cartilage, and the IL-6 levels in the serum and synovial fluid have been reported to be elevated among OA patients [12].
Positive_regulation (elevated) of IL-6 in synovial fluid associated with osteoarthritis
10) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 1.14 Pain Relevance 0.50
There is substantial evidence that the increase in IL-6 serum levels with age results in part from the loss of sex steroids such as estrogen, testosterone and dehydroepiandrosterone [36,37], which have an important role in blocking transcription of the IL-6 gene, so that their loss at menopause may have a more conspicuous role than the genotype.
Positive_regulation (increase) of IL-6 associated with endometriosis (extended)
11) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374458 Disease Relevance 0.86 Pain Relevance 0.37
However, there was an inverse relationship between cortisol and IL-6 responses; the cortisol change at 75 min was inversely correlated with increases in IL-6 at 75 min (r=?
Positive_regulation (increases) of IL-6
12) Confidence 0.69 Published 2010 Journal Journal of Psychosomatic Research Section Body Doc Link PMC2809922 Disease Relevance 0.74 Pain Relevance 0
Plasma IL-6 levels are significantly elevated in ACS patients compared to patients with stable CAD or healthy age-matched controls [45,46], and blood IL-6 levels assessed at or near to the time of hospital admission are a significant independent predictor of subsequent coronary events and mortality [46,47].
Positive_regulation (elevated) of IL-6 in blood associated with acute coronary syndrome and coronary artery disease
13) Confidence 0.69 Published 2010 Journal Journal of Psychosomatic Research Section Body Doc Link PMC2809922 Disease Relevance 1.40 Pain Relevance 0.15
Total CMHS scores were associated with elevated plasma IL-6 concentrations in a small study of healthy men [28].
Positive_regulation (elevated) of IL-6 in plasma
14) Confidence 0.69 Published 2010 Journal Journal of Psychosomatic Research Section Body Doc Link PMC2809922 Disease Relevance 0.55 Pain Relevance 0.08
Serum IL-6 levels were increased, especially at 10 and 20 micrograms/kg/d, whereas no change in IL-1 beta and tumor necrosis factor alpha levels was observed.
Positive_regulation (increased) of IL-6 associated with necrosis and cancer
15) Confidence 0.69 Published 1994 Journal Blood Section Abstract Doc Link 8068939 Disease Relevance 1.18 Pain Relevance 0.17
Laboratory evaluation revealed marked thrombocytosis, hypoalbuminemia, and increased serum concentrations of CRP, fibrinogen and interleukin-6 (IL-6).
Positive_regulation (increased) of IL-6 associated with hypoalbuminemia and thrombosis related under development
16) Confidence 0.69 Published 1996 Journal Intern. Med. Section Abstract Doc Link 8785456 Disease Relevance 0.65 Pain Relevance 0.09
In this patient, the serum level of IL-6 was elevated.
Positive_regulation (elevated) of IL-6
17) Confidence 0.69 Published 2004 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15568483 Disease Relevance 1.00 Pain Relevance 0.36
We report a 25-year old man with cardiac myxoma presenting with multiple cerebellar hemorrhages and elevation of interleukin-6 (IL-6) in the cerebrospinal fluid (CSF).
Positive_regulation (elevation) of IL-6 in CSF associated with myxoma and cva
18) Confidence 0.69 Published 2004 Journal Rinsho Shinkeigaku Section Abstract Doc Link 15568483 Disease Relevance 0.84 Pain Relevance 0.25
Reverse transcriptase-polymerase chain reaction experiments showed that the increase was dependent on the enhancement of IL-6 mRNA levels.
Positive_regulation (increase) of IL-6
19) Confidence 0.68 Published 1998 Journal J Endod Section Abstract Doc Link 9641129 Disease Relevance 0.17 Pain Relevance 0.26
Further investigation showed that IL-1 beta and IL-6 concentrations were increased in spinal fluid but not in serum.
Neg (not) Positive_regulation (increased) of IL-6 in spinal
20) Confidence 0.68 Published 2000 Journal Rinsho Ketsueki Section Abstract Doc Link 10723244 Disease Relevance 0.95 Pain Relevance 0.19

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