INT101942

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 15.24
Pain Relevance 4.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD40, CD40LG) plasma membrane (CD40, CD40LG) extracellular space (CD40LG)
signal transduction (CD40) enzyme binding (CD40) protein complex assembly (CD40)
Anatomy Link Frequency
B cells 4
leucocyte 2
T-cells 2
CD40 (Homo sapiens)
CD40LG (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 196 99.32 Very High Very High Very High
Inflammatory mediators 3 97.32 Very High Very High Very High
Arthritis 252 96.28 Very High Very High Very High
rheumatoid arthritis 94 96.12 Very High Very High Very High
antagonist 40 89.96 High High
cytokine 201 88.40 High High
chemokine 7 87.52 High High
Inflammatory marker 15 85.52 High High
tolerance 11 82.20 Quite High
Inflammatory response 10 81.52 Quite High
Disease Link Frequency Relevance Heat
Nephritis 4 99.64 Very High Very High Very High
INFLAMMATION 214 99.32 Very High Very High Very High
Systemic Lupus Erythematosus 218 99.14 Very High Very High Very High
Increased Venous Pressure Under Development 175 98.24 Very High Very High Very High
Apoptosis 74 97.92 Very High Very High Very High
Adhesions 38 97.56 Very High Very High Very High
Juvenile Chronic Polyarthritis 219 96.28 Very High Very High Very High
Rheumatoid Arthritis 97 96.12 Very High Very High Very High
Leukemia 55 95.92 Very High Very High Very High
Disease 237 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, there is a chain of molecular events including engagement of CD154 (CD40L) on Th2 cells and CD40 on B cells, along with engagement of CD28 and CD80/86 on Th2 and B cells respectively.
CD40 Binding (engagement) of CD154 in B cells
1) Confidence 0.23 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.70 Pain Relevance 0.30
CD40 interacts with CD40 ligand (CD40L or CD154) which is predominantly expressed on activated CD4+ T-cells [12].
CD40 Binding (ligand) of CD40L in T-cells
2) Confidence 0.21 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.21 Pain Relevance 0.58
CD40 interacts with CD40 ligand (CD40L or CD154) which is predominantly expressed on activated CD4+ T-cells [12].
CD40 Binding (ligand) of CD154 in T-cells
3) Confidence 0.21 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.21 Pain Relevance 0.59
Furthermore, an anti-CD154 antibody, IDEC-131 (a humanized antibody that blocks CD40-CD154 interactions [31]), was well tolerated in a phase II study conducted in 85 patients with mild-to-moderate SLE [32]; however, it failed to meet the primary efficacy end-point, namely a reduction in SLEDAI score at 20 weeks after six infusions of IDEC-131 ranging from 2.5 to 10 mg/kg.
CD40 Binding (interactions) of CD154 associated with systemic lupus erythematosus
4) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.69 Pain Relevance 0.06
Early studies in SLE murine models suggested that blocking the interaction between CD40 and CD154 reduced nephritis and anti-dsDNA antibodies, leading to improved survival [28-30].
CD40 Binding (interaction) of CD154 associated with nephritis and systemic lupus erythematosus
5) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.64 Pain Relevance 0.07
Furthermore, an anti-CD154 antibody, IDEC-131 (a humanized antibody that blocks CD40-CD154 interactions [31]), was well tolerated in a phase II study conducted in 85 patients with mild-to-moderate SLE [32]; however, it failed to meet the primary efficacy end-point, namely a reduction in SLEDAI score at 20 weeks after six infusions of IDEC-131 ranging from 2.5 to 10 mg/kg.
CD40 Binding (interactions) of CD154 associated with systemic lupus erythematosus
6) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.69 Pain Relevance 0.06
Early studies in SLE murine models suggested that blocking the interaction between CD40 and CD154 reduced nephritis and anti-dsDNA antibodies, leading to improved survival [28-30].
CD40 Binding (interaction) of CD154 associated with nephritis and systemic lupus erythematosus
7) Confidence 0.18 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592791 Disease Relevance 0.64 Pain Relevance 0.07
We speculate that sCD154 could possibly interact with cells bearing CD40, possibly enhancing antigen presentation, and production of other inflammatory mediators in JIA.
CD40 Binding (interact) of sCD154 associated with inflammatory mediators and arthritis
8) Confidence 0.17 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 1.28 Pain Relevance 0.59
On engagement of T and B cells, the T cell becomes activated and expresses CD40L, which in turn binds CD40 on the B cell, initiating the process of somatic hypermutation of the immunoglobulin gene and class switching.
CD40 Binding (binds) of CD40L in B cell
9) Confidence 0.15 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661661 Disease Relevance 0.67 Pain Relevance 0.34
CD40-ligand (CD40L) enhances B cell survival and prevents BCR-induced apoptosis
CD40 Binding (ligand) of CD40L in B cell associated with apoptosis
10) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408681 Disease Relevance 1.32 Pain Relevance 0.04
Subsequently, there is a chain of molecular events including engagement of CD154 (CD40L) on Th2 cells and CD40 on B cells, along with engagement of CD28 and CD80/86 on Th2 and B cells respectively.
CD40 Binding (engagement) of CD40L in B cells
11) Confidence 0.11 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.70 Pain Relevance 0.30
BACKGROUND: Increasing evidence indicates that the CD40-CD40L interaction plays a pivotal role in the inflammatory regulation of atherosclerosis.
CD40 Binding (interaction) of CD40L associated with inflammation, increased venous pressure under development and adhesions
12) Confidence 0.08 Published 2002 Journal Clin. Chim. Acta Section Abstract Doc Link 11922919 Disease Relevance 0.86 Pain Relevance 0.20
BACKGROUND: Increasing evidence indicates that the CD40-CD40L interaction plays a pivotal role in the inflammatory regulation of atherosclerosis.
CD40 Binding (interaction) of CD40L associated with inflammation, increased venous pressure under development and adhesions
13) Confidence 0.08 Published 2002 Journal Clin. Chim. Acta Section Abstract Doc Link 11922919 Disease Relevance 0.86 Pain Relevance 0.20
Cell surface-based signaling system CD40L ligand (CD154), binding to its receptor CD40 on the leucocyte, can induce tissue factor expression [50].
CD40 Binding (binding) of CD154 in leucocyte
14) Confidence 0.06 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.01 Pain Relevance 0.30
Cell surface-based signaling system CD40L ligand (CD154), binding to its receptor CD40 on the leucocyte, can induce tissue factor expression [50].
CD40 Binding (binding) of CD40L in leucocyte
15) Confidence 0.06 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.02 Pain Relevance 0.30
Hyper IgM (HIGM) syndrome is a rare primary immunodeficiency disease caused by impaired Immunoglobulin class switch recombination (CSR) and characterized by normal or high IgM along with low or undetectable immunoglobulin subtypes including IgG, IgA and IgE.[60] Different molecular causes have been described that result in different HIGM phenotypes including defects of CD40 ligand (CD40L), CD40, nuclear factor-?
CD40 Binding (ligand) of CD40L associated with syndrome, disease and immunodeficiency
16) Confidence 0.01 Published 2010 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC3016508 Disease Relevance 1.74 Pain Relevance 0

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