INT101945

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.96
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Grm5) plasma membrane (Grm5) cytoplasm (Grm5)
signal transducer activity (Grm5)
Anatomy Link Frequency
neuronal 1
sciatic nerve 1
Grm5 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 45 99.96 Very High Very High Very High
Sciatic nerve 5 99.80 Very High Very High Very High
Spinal nerve ligature 4 96.16 Very High Very High Very High
antagonist 16 92.48 High High
Spinal cord 1 90.04 High High
Thermal hyperalgesia 5 88.80 High High
Brush evoked pain 2 86.80 High High
cocaine 99 85.68 High High
Glutamate receptor 8 80.56 Quite High
Hyperalgesia 1 63.92 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 108 95.48 Very High Very High Very High
Hyperalgesia 6 88.80 High High
Neuropathic Pain 2 86.80 High High
Nervous System Injury 3 75.00 Quite High
Anxiety Disorder 57 58.40 Quite High
Injury 1 32.72 Quite Low
Body Weight 6 5.00 Very Low Very Low Very Low
Alcohol Addiction 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To determine if altered mGluR5 expression levels also affected locomotor activity relevant to OSS, we tested locomotor activity in a novel environment and after habituation.
Spec (determine) Regulation (affected) of Gene_expression (expression) of mGluR5 associated with eae
1) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.12 Pain Relevance 0.42
To determine if altered mGluR5 expression levels also affected locomotor activity relevant to OSS, we tested locomotor activity in a novel environment and after habituation.
Spec (determine) Regulation (altered) of Gene_expression (expression) of mGluR5 associated with eae
2) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.12 Pain Relevance 0.42
Analysis of FR-1 operant responding for food reinforcer revealed no significant effect of mGluR5 genotype on either active (F(2,91)?
Neg (no) Regulation (effect) of Gene_expression (genotype) of mGluR5
3) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2994905 Disease Relevance 0.15 Pain Relevance 0
Interestingly, after partial sciatic nerve section, mGluR5 expression did not change in either L4 or L5 DRG neuronal profiles.
Neg (not) Regulation (change) of in neuronal Gene_expression (expression) of mGluR5 in sciatic nerve associated with sciatic nerve
4) Confidence 0.07 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11923431 Disease Relevance 0.57 Pain Relevance 1.15

General Comments

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