INT101950

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.26
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lateral 1
enteric nervous system 1
Crhq1 (Mus musculus)
Pain Link Frequency Relevance Heat
spastic colon 196 99.54 Very High Very High Very High
antagonist 7 98.36 Very High Very High Very High
Eae 1 98.24 Very High Very High Very High
analgesia 1 96.32 Very High Very High Very High
lidocaine 1 92.60 High High
Pain 2 86.72 High High
cytokine 8 80.84 Quite High
amygdala 2 75.00 Quite High
abdominal pain 13 51.56 Quite High
agonist 1 48.48 Quite Low
Disease Link Frequency Relevance Heat
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

194 99.54 Very High Very High Very High
Shock 1 90.96 High High
Pain 2 86.72 High High
Stress 28 86.60 High High
Targeted Disruption 6 84.36 Quite High
Hematological Disease 12 79.76 Quite High
Abdominal Pain 13 51.56 Quite High
Dyspepsia 9 31.92 Quite Low
Brain Disease 1 25.56 Quite Low
INFLAMMATION 17 15.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, CRH2 receptors were acutely blocked by alpha-helical CRH (alpha(h)CRH, CRH1/CRH2 antagonist; 0, 30, 100, and 300 ng) infusion into the lateral septum (LS), which abundantly expresses CRH2 but not CRH1 receptors.
Gene_expression (expresses) of CRH1 in lateral associated with antagonist
1) Confidence 0.68 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11923457 Disease Relevance 0.59 Pain Relevance 0.42
-helical CRH clearly decreases colonic motility in IBS patients, probably by antagonizing CRH1 in the enteric nervous system.100
Gene_expression (antagonizing) of CRH1 in enteric nervous system associated with spastic colon
2) Confidence 0.09 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2879849 Disease Relevance 0.13 Pain Relevance 0.64
In addition, the BDNF receptor (NTRK2) and CRH1 gene expression increased following NGF exposure, but did not meet the threshold cutoff in cells exposed to BDNF.
Gene_expression (expression) of CRH1 gene
3) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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