INT101954

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.23
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Crhr2) Golgi apparatus (Crhr2) endoplasmic reticulum (Crhr2)
plasma membrane (Crhr2) signal transducer activity (Crhr2)
Crhr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 99.96 Very High Very High Very High
Serotonin 11 99.70 Very High Very High Very High
amygdala 18 94.32 High High
antagonist 5 91.88 High High
Hippocampus 4 91.80 High High
cerebral cortex 6 83.00 Quite High
Pain 3 82.88 Quite High
analgesia 1 78.28 Quite High
Eae 3 77.68 Quite High
antidepressant 4 63.84 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 103 99.60 Very High Very High Very High
Pain 3 82.88 Quite High
Shock 3 80.80 Quite High
Stress 72 75.00 Quite High
Targeted Disruption 23 59.36 Quite High
Anxiety Disorder 25 5.00 Very Low Very Low Very Low
Depression 19 5.00 Very Low Very Low Very Low
Hyponatremia 10 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Small Cell Lung Cancer 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several serotonin receptors and Crhr2 also contain non-synonymous coding SNPs, but none associate with the strain-dependent TST immobility scores we observed.
Crhr2 Binding (associate) of associated with sprains and strains and serotonin
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012073 Disease Relevance 0.52 Pain Relevance 0.32
Ex vivo autoradiography revealed that binding of [125I]sauvagine, a mixed CRH1/CRH2 agonist, was prevented in the LS by previous intra-LS infusion of alpha(h)CRH but not NBI27914.
CRH2 Binding (binding) of associated with agonist
2) Confidence 0.19 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 11923457 Disease Relevance 0.59 Pain Relevance 0.54
CRH mainly binds CRHR1, but not CRHR2.
CRHR2 Binding (binds) of
3) Confidence 0.15 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.06 Pain Relevance 0.22
On the other hand, all Ucns bind CRHR2 with high affinity.
CRHR2 Binding (bind) of
4) Confidence 0.13 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.05 Pain Relevance 0.25

General Comments

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