INT101957

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 30
Total Number 30
Disease Relevance 16.57
Pain Relevance 4.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
liver 4
bone marrow 3
brain 2
mononuclear cells 2
retinas 1
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 7 99.60 Very High Very High Very High
Hippocampus 9 99.22 Very High Very High Very High
ischemia 273 99.12 Very High Very High Very High
dexamethasone 86 98.46 Very High Very High Very High
withdrawal 14 98.12 Very High Very High Very High
Inflammation 6 89.40 High High
allodynia 2 87.12 High High
depression 2 85.28 High High
Sciatic nerve 10 85.00 Quite High
Spinal cord 10 84.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 699 100.00 Very High Very High Very High
Necrosis 73 99.34 Very High Very High Very High
Retina Disease 68 99.12 Very High Very High Very High
Stress 51 98.92 Very High Very High Very High
Cv Unclassified Under Development 175 97.96 Very High Very High Very High
Injury 156 97.40 Very High Very High Very High
Ocular Hypertension 32 96.60 Very High Very High Very High
Leukemia 58 96.28 Very High Very High Very High
Death 162 94.00 High High
Diabetes Mellitus 20 92.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Appreciable levels of Bcl-2 mRNA and protein expression were observed in liver tissues of L-arginine treated with the matching sham-operated rat.
Transcription (expression) of Bcl-2 in liver
1) Confidence 0.69 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.73 Pain Relevance 0.11
Appreciable levels of Bcl-2 mRNA and protein expression were observed in liver tissues of L-arginine treated with the matching sham-operated rat.
Transcription (levels) of Bcl-2 in liver
2) Confidence 0.69 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.73 Pain Relevance 0.11
Our results showed that 20 microM FL treatment can significantly increase the proliferation rate of NSCs (p<0.05), and up-regulate the mRNA and protein expressions of Bcl-2 in Day-7 FL-treated NSCs (p<0.01).
Transcription (expressions) of Bcl-2 in NSCs associated with fluoxetine
3) Confidence 0.69 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.40 Pain Relevance 0.95
Developmental A1254 exposure had no effect on cortical or striatal levels of Bcl2 mRNA in either sex at PND7 (Figure 5A,C).
Transcription (levels) of Bcl2
4) Confidence 0.67 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.12 Pain Relevance 0
Ischemia for 1 h followed by 3 h reperfusion resulted in significant (P < 0.05) decreases in mRNA and protein expression of Bcl-2 when compared with L-arginine-treated rats [Figures 2 and 3].


Transcription (expression) of Bcl-2 associated with ischemia
5) Confidence 0.66 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.64 Pain Relevance 0.08
To investigate the mechanism of L-arginine on necrosis and apoptosis, mRNA and protein expression of the Bcl-2 in ischemic liver tissue followed by 3 h reperfusion was measured by RT-PCR and Western blot techniques.
Transcription (expression) of Bcl-2 in liver associated with necrosis and apoptosis
6) Confidence 0.66 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.77 Pain Relevance 0.13
In another report, retinal ischemia was shown to induce an initial decrease in Bcl-2 mRNA expression followed by a later increase in its expression [21].
Transcription (expression) of Bcl-2 associated with ischemia and retina disease
7) Confidence 0.65 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.83 Pain Relevance 0.29
As for mRNA, the Bax:Bcl-2 and Bax:Bcl-xL protein ratios did not reveal any modulation (1.144±0.238 and 0.970±0.129, respectively; Figure 2E-F).


Transcription (ratios) of Bcl-2
8) Confidence 0.63 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0 Pain Relevance 0.06
Although slight differences between mRNA and protein regulation were obtained in ischemic and control retinas, Bax:Bcl-2 and Bax:Bcl-xL ratios were similarly modulated over time.
Transcription (modulated) of Bcl-2 in retinas
9) Confidence 0.63 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.61 Pain Relevance 0.26
Oblimersen (Genasense®, Bcl-2 antisense, G3139) is a synthetic, 18-base, single-stranded phosphorothioate DNA oligonucleotide designed to downregulate bcl-2 mRNA expression (Klasa et al 2002).
Transcription (expression) of bcl-2
10) Confidence 0.58 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.46 Pain Relevance 0
At 1 h after CPB, in 6 rats per group, hippocampus was processed for the apoptotic gene (bcl-2 and bax) messenger RNAs detection by reverse transcriptase polymerase chain reaction, and messenger RNA expression was determined by the ratio of the polymerase chain reaction product of bcl-2 or bax to the beta-actin gene.
Transcription (detection) of bcl-2 in hippocampus associated with hippocampus and apoptosis
11) Confidence 0.57 Published 2006 Journal Anesth. Analg. Section Abstract Doc Link 16551891 Disease Relevance 0.41 Pain Relevance 0.25
These same investigators assessed the relationship between clinical response, plasma and intracellular oblimersen levels, and changes in bcl-2 mRNA and Bcl-2 protein levels in bone marrow mononuclear cells in 22 elderly patients treated with oblimersen and chemotherapy for previously untreated acute myeloid leukemia (Marcucci et al 2005).
Transcription (levels) of bcl-2 in mononuclear cells associated with leukemia
12) Confidence 0.56 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.22 Pain Relevance 0
These same investigators assessed the relationship between clinical response, plasma and intracellular oblimersen levels, and changes in bcl-2 mRNA and Bcl-2 protein levels in bone marrow mononuclear cells in 22 elderly patients treated with oblimersen and chemotherapy for previously untreated acute myeloid leukemia (Marcucci et al 2005).
Transcription (levels) of Bcl-2 in mononuclear cells associated with leukemia
13) Confidence 0.56 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.22 Pain Relevance 0
Among the 8 patients, downregulation of bcl-2 mRNA in bone marrow was observed in 4 patients; bcl-2 mRNA was unchanged in 2 patients and increased in 2 patients.
Transcription (observed) of bcl-2 in bone marrow
14) Confidence 0.56 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.20 Pain Relevance 0
Among the 8 patients, downregulation of bcl-2 mRNA in bone marrow was observed in 4 patients; bcl-2 mRNA was unchanged in 2 patients and increased in 2 patients.
Transcription (mRNA) of bcl-2 in bone marrow
15) Confidence 0.56 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.20 Pain Relevance 0
Bone marrow aspirates from 12 patients were assessed for bcl-2 mRNA, of which 9 (75%) showed downregulation.
Transcription (assessed) of bcl-2 in Bone marrow
16) Confidence 0.56 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.16 Pain Relevance 0
The strong decline of Bcl-xL was further amplified in the Bax:Bcl-xL ratio (1.446±0.106; p<0.005; Figure 3F) Bcl-2 was not significantly modulated (0.759±0.116), nor was the Bax:Bcl-2 ratio (1.194±0.132, Figure 3C,E).


Neg (not) Transcription (modulated) of Bcl-2
17) Confidence 0.55 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2765238 Disease Relevance 0.06 Pain Relevance 0
Effects of L-arginine in expression of Bcl-2 mRNA and protein
Transcription (expression) of Bcl-2
18) Confidence 0.51 Published 2009 Journal Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association Section Body Doc Link PMC2841413 Disease Relevance 0.78 Pain Relevance 0.14
The G-CSF also increased the expression of pSTAT3, Bcl-2, and cIAP2 proteins as well as Bcl-2 mRNA, but inhibited Bax protein expression in the brain.
Transcription (expression) of Bcl-2 in brain
19) Confidence 0.51 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.39 Pain Relevance 0.18
The G-CSF also increased the expression of pSTAT3, Bcl-2, and cIAP2 proteins as well as Bcl-2 mRNA, but inhibited Bax protein expression in the brain.
Transcription (expression) of Bcl-2 in brain
20) Confidence 0.51 Published 2008 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 18832793 Disease Relevance 1.39 Pain Relevance 0.18

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