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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.22
Pain Relevance 1.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2) aging (Bcl2) cell morphogenesis (Bcl2)
endoplasmic reticulum (Bcl2) intracellular (Bcl2) response to stress (Bcl2)
Anatomy Link Frequency
bone marrow 2
NSCs 2
Bcl2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fluoxetine 7 99.60 Very High Very High Very High
withdrawal 7 98.32 Very High Very High Very High
dexamethasone 43 97.74 Very High Very High Very High
Hippocampus 3 89.28 High High
allodynia 1 87.12 High High
depression 2 86.60 High High
Sciatic nerve 1 85.00 Quite High
Spinal cord 1 84.04 Quite High
Neurotransmitter 1 80.12 Quite High
antidepressant 3 77.52 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 122 100.00 Very High Very High Very High
Injury 6 99.44 Very High Very High Very High
Neuropathic Pain 2 87.12 High High
Depression 2 86.60 High High
Osteoporosis 27 85.68 High High
Neurodegenerative Disease 1 82.68 Quite High
Leukemia 8 75.12 Quite High
Pain 4 74.64 Quite High
Stress 2 71.92 Quite High
Solid Tumor 6 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results showed that 20 microM FL treatment can significantly increase the proliferation rate of NSCs (p<0.05), and up-regulate the mRNA and protein expressions of Bcl-2 in Day-7 FL-treated NSCs (p<0.01).
Positive_regulation (up-regulate) of Transcription (expressions) of Bcl-2 in NSCs associated with fluoxetine
1) Confidence 0.50 Published 2007 Journal Current neurovascular research Section Abstract Doc Link 17311541 Disease Relevance 0.40 Pain Relevance 0.95
The mRNA expression levels of the bcl-2 genes family was changed as follows: bax increased up to 40% in CCI vs the sham rats, while bcl-2 did not change; bcl-xS massively decreased (by 70% and 100%), while bcl-xL increased (by 40%) in CCI rats.
Positive_regulation (increased) of Transcription (expression) of bcl-2 associated with injury
2) Confidence 0.41 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924868 Disease Relevance 1.10 Pain Relevance 0.42
Among the 8 patients, downregulation of bcl-2 mRNA in bone marrow was observed in 4 patients; bcl-2 mRNA was unchanged in 2 patients and increased in 2 patients.
Positive_regulation (increased) of Transcription (mRNA) of bcl-2 in bone marrow
3) Confidence 0.40 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376092 Disease Relevance 0.20 Pain Relevance 0
Analogous to, although different from the observed effects of Dex exposure, mitogen withdrawal also did not decrease expression of any prosurvival genes, and instead resulted in increased transcription of the anti-apoptotic proteins Bcl-2, IAP-1, IAP-2, FLIPLong and FLIPShort.
Positive_regulation (increased) of Transcription (transcription) of anti-apoptotic proteins Bcl-2 associated with apoptosis, withdrawal and dexamethasone
4) Confidence 0.09 Published 2007 Journal The Journal of Endocrinology Section Body Doc Link PMC2173947 Disease Relevance 0.52 Pain Relevance 0.28

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