INT10196

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Context Info
Confidence 0.25
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.19
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Dclk2) cytoplasm (Dclk2)
Anatomy Link Frequency
colon 1
Dclk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 11 99.08 Very High Very High Very High
anesthesia 1 91.56 High High
Opioid 1 75.00 Quite High
Inflammation 37 69.88 Quite High
rapifen 2 25.00 Low Low
Neuropeptide 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 9 89.76 High High
Bronchospasm 2 85.76 High High
Injury 92 85.20 High High
Necrosis 2 83.44 Quite High
Pressure And Volume Under Development 39 75.72 Quite High
Diarrhoea 2 73.16 Quite High
Toxicity 15 71.44 Quite High
Inflammatory Bowel Disease 4 70.44 Quite High
Cough 3 53.48 Quite High
Lung Injury 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many anesthetic drugs fit a three-compartment mamillary model, with three volumes of distribution (central [V1] and peripheral [V2 and V3]) and three clearances (elimination or metabolic [Cl1] and distribution [Cl2 and Cl3]).
Localization (distribution) of Cl2
1) Confidence 0.25 Published 1994 Journal Anesthesiology Section Abstract Doc Link 7943834 Disease Relevance 0 Pain Relevance 0.17
Although TTX (0.5 microM) increased the lag time for achievement of the maximal Isc response to NH2Cl, the neurotoxin did not inhibit the effect of diamide, suggesting that diamide acts primarily on the nonneural component of NH2Cl-stimulated secretion.
Localization (secretion) of NH2Cl associated with tetrodotoxin
2) Confidence 0.05 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8338125 Disease Relevance 0 Pain Relevance 0.23
Taken together, the results support a role for epithelial cell thiols in NH2Cl-stimulated electrolyte secretion by the rat colon.
Localization (secretion) of NH2Cl in colon
3) Confidence 0.05 Published 1993 Journal Am. J. Physiol. Section Abstract Doc Link 8338125 Disease Relevance 0 Pain Relevance 0.19
Effect of the thiol-oxidizing agent diamide on NH2Cl-induced rat colonic electrolyte secretion.
Localization (secretion) of NH2Cl
4) Confidence 0.05 Published 1993 Journal Am. J. Physiol. Section Title Doc Link 8338125 Disease Relevance 0 Pain Relevance 0.25
Tetrodotoxin (5 microM) did not significantly inhibit the NH2Cl-evoked transmitter release.
Localization (release) of NH2Cl associated with tetrodotoxin
5) Confidence 0.05 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1469620 Disease Relevance 0.25 Pain Relevance 0.15
Glutathione inhibited the NH2Cl-evoked release in a concentration-dependent fashion.
Localization (release) of NH2Cl
6) Confidence 0.05 Published 1992 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1469620 Disease Relevance 0.27 Pain Relevance 0.14
Oxygen radicals are also released; chlorine (Cl2) is released with combustion of plastics and resins and is a common bleaching agent.
Localization (released) of Cl2
7) Confidence 0.04 Published 2008 Journal Eplasty Section Body Doc Link PMC2396464 Disease Relevance 0.68 Pain Relevance 0

General Comments

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