INT101985

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.15
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.13
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs1) nuclear envelope (Ptgs1) oxidoreductase activity (Ptgs1)
Golgi apparatus (Ptgs1) endoplasmic reticulum (Ptgs1) plasma membrane (Ptgs1)
Anatomy Link Frequency
spinal cord 2
Ptgs1 (Mus musculus)
Pain Link Frequency Relevance Heat
COX2 16 99.88 Very High Very High Very High
Inflammation 54 99.48 Very High Very High Very High
IPN 1 98.04 Very High Very High Very High
Spinal cord 29 97.44 Very High Very High Very High
qutenza 19 96.28 Very High Very High Very High
Pain 12 93.60 High High
dorsal root ganglion 22 93.00 High High
intrathecal 3 92.72 High High
agonist 11 89.76 High High
Hyperalgesia 4 86.80 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 53 99.48 Very High Very High Very High
Malignant Neoplastic Disease 2 98.36 Very High Very High Very High
Inflammatory Pain 2 98.04 Very High Very High Very High
Sprains And Strains 13 97.48 Very High Very High Very High
Mycobacterial Infection 96 97.20 Very High Very High Very High
Pain 12 93.60 High High
Pressure And Volume Under Development 3 93.24 High High
Ganglion Cysts 22 93.00 High High
Cancer 28 90.00 High High
Infection 62 89.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intraplantar injection of carrageenan markedly induced the expression of prostacyclin receptor (IP receptor) mRNA with the maximum at 6 h, coincidently induction of the inducible form of cyclooxygenase (COX-2), although IP receptor mRNA was weakly expressed in the spinal cord of naive mice.
Positive_regulation (induced) of Positive_regulation (induction) of cyclooxygenase in spinal cord associated with spinal cord
1) Confidence 0.15 Published 2002 Journal Neuroreport Section Abstract Doc Link 11924902 Disease Relevance 0.60 Pain Relevance 0.61
COX2, the inducible PGH synthase, is required for prostanoid synthesis (40).
Positive_regulation (required) of Positive_regulation (inducible) of PGH synthase associated with cox2
2) Confidence 0.04 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2585850 Disease Relevance 1.58 Pain Relevance 0.31
As it was postulated before, the inducible cyclooxygenase isoenzyme, COX-2, is significantly overexpressed at sites of inflammation and in various malignant tissues, with concomitant overproduction of the major arachidonate metabolite, PGE2 [43].
Positive_regulation (overexpressed) of Positive_regulation (inducible) of cyclooxygenase isoenzyme associated with malignant neoplastic disease and inflammation
3) Confidence 0.02 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3004002 Disease Relevance 0.84 Pain Relevance 0.17
The increased cobalt staining in these experiments is dependent on the activation of cyclooxygenase, in contrast to other findings [29].
Positive_regulation (dependent) of Positive_regulation (activation) of cyclooxygenase
4) Confidence 0.02 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2936303 Disease Relevance 1.11 Pain Relevance 0.90

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox