INT101986

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Context Info
Confidence 0.52
First Reported 2002
Last Reported 2006
Negated 0
Speculated 3
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 2.45
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (TP53) nucleoplasm (TP53) mitochondrion (TP53)
DNA binding (TP53) extracellular space (GDF15) nucleus (TP53)
Anatomy Link Frequency
colon 4
TP53 (Homo sapiens)
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 10 100.00 Very High Very High Very High
cytokine 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Cancer 5 100.00 Very High Very High Very High
Apoptosis 37 99.90 Very High Very High Very High
Colon Cancer 6 98.24 Very High Very High Very High
INFLAMMATION 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of apoptosis in cells of human colon cancer cell lines after gamma irradiation was investigated to determine whether apoptosis was mediated by TP53 and the subsequent expression of its downstream target, the NSAID-activated gene (NAG1).
TP53 Spec (whether) Positive_regulation (mediated) of Gene_expression (expression) of NAG1 in colon associated with colon cancer, cinod and apoptosis
1) Confidence 0.52 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.69 Pain Relevance 0.17
The findings reported here indicate that gamma radiation activates the TP53 tumor suppressor, which then increases the expression of NAG1.
TP53 Positive_regulation (increases) of Gene_expression (expression) of NAG1 associated with cancer
2) Confidence 0.52 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.67 Pain Relevance 0.07
The induction of apoptosis in cells of human colon cancer cell lines after gamma irradiation was investigated to determine whether apoptosis was mediated by TP53 and the subsequent expression of its downstream target, the NSAID-activated gene (NAG1).
TP53 Spec (whether) Positive_regulation (mediated) of Gene_expression (expression) of NSAID-activated gene in colon associated with colon cancer, cinod and apoptosis
3) Confidence 0.45 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.68 Pain Relevance 0.17
Thus, DADS-induced apoptosis and NAG-1 protein expression appear to occur via p53.
p53 Spec (appear) Positive_regulation (occur) of Gene_expression (expression) of NAG-1 protein associated with apoptosis
4) Confidence 0.23 Published 2002 Journal J. Nutr. Section Abstract Doc Link 11925476 Disease Relevance 0.41 Pain Relevance 0.25

General Comments

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