INT101987

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 3.18
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDF15) extracellular space (GDF15) extracellular region (GDF15)
cell-cell signaling (GDF15)
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 14 93.40 High High
Inflammation 2 90.68 High High
antagonist 23 55.76 Quite High
cytokine 4 25.00 Low Low
agonist 28 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 156 99.84 Very High Very High Very High
INFLAMMATION 4 93.20 High High
Colon Cancer 16 92.08 High High
Cancer 72 85.68 High High
Stress 8 76.52 Quite High
Intestinal Cancer 1 75.00 Quite High
Death 28 61.20 Quite High
Reprotox - General 1 4 45.96 Quite Low
Multiple Myeloma 1 43.92 Quite Low
Epstein-barr Virus 1 42.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of NAG-1 by small interfering RNA suppressed MCC-555-induced apoptosis.
Negative_regulation (regulation) of NAG-1 associated with apoptosis
1) Confidence 0.36 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731769 Disease Relevance 0.78 Pain Relevance 0.09
Instead, PKR mediated activation of pro-survival extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway, which was enhanced by NAG-1 suppression in response to cytotoxic sulindac sulfide exposure.
Negative_regulation (suppression) of NAG-1
2) Confidence 0.31 Published 2010 Journal Carcinogenesis Section Abstract Doc Link 20130018 Disease Relevance 0.91 Pain Relevance 0.46
In HCT-116 cells, DADS induced p53 and NAG-1 in a dose-dependent manner and the induction of p53 preceded that of NAG-1.
Negative_regulation (preceded) of NAG-1
3) Confidence 0.21 Published 2002 Journal J. Nutr. Section Abstract Doc Link 11925476 Disease Relevance 0.58 Pain Relevance 0.32
downregulation of NAG-1 by siRNA suppressed MCC-555-induced apoptosis [41].
Negative_regulation (downregulation) of NAG-1 associated with apoptosis
4) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.91 Pain Relevance 0.16

General Comments

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