INT101988

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 71
Total Number 75
Disease Relevance 51.03
Pain Relevance 18.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDF15) extracellular space (GDF15) extracellular region (GDF15)
cell-cell signaling (GDF15)
Anatomy Link Frequency
MCF-7 4
macrophage 2
colon 2
HCT 116 1
A549 1
GDF15 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 279 100.00 Very High Very High Very High
cytokine 111 100.00 Very High Very High Very High
Inflammation 173 99.36 Very High Very High Very High
aspirin 29 98.94 Very High Very High Very High
agonist 75 97.66 Very High Very High Very High
Kinase C 20 96.10 Very High Very High Very High
antagonist 54 88.52 High High
Cannabinoid receptor 2 86.04 High High
metalloproteinase 6 57.28 Quite High
Pain 8 55.32 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 640 100.00 Very High Very High Very High
Cancer 411 100.00 Very High Very High Very High
INFLAMMATION 279 100.00 Very High Very High Very High
Recurrence 3 99.48 Very High Very High Very High
Colorectal Cancer 190 99.28 Very High Very High Very High
Carcinoma 19 99.18 Very High Very High Very High
Ovarian Cancer 34 99.14 Very High Very High Very High
Stress 93 99.00 Very High Very High Very High
Colon Cancer 128 98.68 Very High Very High Very High
Adhesions 8 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The induction of NAG-1 expression by AHPN is caused at least in part by an 8-fold increase in the stability of NAG-1 mRNA.
Positive_regulation (increase) of NAG-1 mRNA
1) Confidence 0.69 Published 2003 Journal Mol. Pharmacol. Section Abstract Doc Link 12606762 Disease Relevance 0.67 Pain Relevance 0.23
The dramatic increase of the nonsteroidal anti-inflammatory drug-activated gene 1 (NAG-1) made this gene an interesting candidate regarding the possible mechanism by which prodigiosin induces cytotoxicity in MCF-7 cells.
Positive_regulation (increase) of NAG-1 in MCF-7 associated with inflammation and cinod
2) Confidence 0.68 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.66 Pain Relevance 0.10
Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells.
Positive_regulation (induces) of NAG-1 associated with breast cancer and cytokine
3) Confidence 0.68 Published 2007 Journal Mol. Cancer Ther. Section Title Doc Link 17237295 Disease Relevance 0.54 Pain Relevance 0.18
Our results show that prodigiosin triggers accumulation of the DNA-damage response tumor-suppressor protein p53 but that NAG-1 induction was independent of p53 accumulation.
Positive_regulation (induction) of NAG-1 associated with cancer
4) Confidence 0.68 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.66 Pain Relevance 0.09
To this end, the effect of several NSAIDs on ovarian cancer cells was investigated as assessed by the induction of NAG-1/MIC-1/GDF-15, a proapoptotic gene belonging to the transforming growth factor-beta superfamily.
Spec (investigated) Positive_regulation (induction) of MIC-1 associated with ovarian cancer and cinod
5) Confidence 0.67 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15767558 Disease Relevance 0.61 Pain Relevance 0.43
In conclusion, indomethacin exerts proapoptotic and antitumorigenic effects in sinonasal cancer cells through the induction of NAG-1 and can be considered a safe and effective chemopreventive agent against sinonasal cancer.
Positive_regulation (induction) of NAG-1 associated with cancer
6) Confidence 0.66 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 1.10 Pain Relevance 0.33
Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) has recently been shown to be induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and to have proapoptotic and antitumorigenic activities.
Positive_regulation (induced) of NAG-1 associated with inflammation and cinod
7) Confidence 0.66 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 0.75 Pain Relevance 0.65
The transfection of a NAG1 siRNA into HCT116 cells suppressed radiation-induced apoptosis and inhibited the induction of NAG1 protein without altering the expression of TP53. a NAG1 luciferase promoter construct that included both of the TP53 binding sites, was activated by radiation in dose-dependent manner, while the promoters lacking one or both of the TP53 binding sites in the NAG1 promoter activity either was less responsive or did not respond.
Positive_regulation (induction) of NAG1 protein associated with apoptosis
8) Confidence 0.64 Published 2006 Journal Radiat. Res. Section Abstract Doc Link 16435911 Disease Relevance 0.90 Pain Relevance 0.13
Patients who experienced bone relapse had significantly higher levels of baseline MIC-1 compared with patients who did not (1476.7 versus 988.4; P = 0.03).
Positive_regulation (levels) of baseline MIC-1 associated with recurrence
9) Confidence 0.61 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17372249 Disease Relevance 1.02 Pain Relevance 0.08
Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) was previously identified as a gene induced by several anti-tumorigenic compounds including nonsteroidal anti-inflammatory drugs, peroxisome proliferator-activated receptor gamma ligands, and dietary compounds.
Positive_regulation (induced) of NAG-1 associated with inflammation and cinod
10) Confidence 0.59 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15377673 Disease Relevance 0.52 Pain Relevance 0.27
The dramatic increase of the nonsteroidal anti-inflammatory drug-activated gene 1 (NAG-1) made this gene an interesting candidate regarding the possible mechanism by which prodigiosin induces cytotoxicity in MCF-7 cells.
Positive_regulation (increase) of nonsteroidal anti-inflammatory drug-activated gene 1 in MCF-7 associated with inflammation and cinod
11) Confidence 0.59 Published 2007 Journal Mol. Cancer Ther. Section Abstract Doc Link 17237295 Disease Relevance 0.60 Pain Relevance 0.10
The expression of NF-kappa B p65 induced NAG-1 promoter activity, and chromatin immunoprecipitation assay for p65 showed that NF-kappa B binds the NAG-1 promoter in LNCaP cells.
Positive_regulation (induced) of NAG-1
12) Confidence 0.58 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.42 Pain Relevance 0.25
Inhibition of TPA-induced NAG-1 expression by NAG-1 short interfering RNA blocked TPA-induced apoptosis in LNCaP cells, suggesting induction of NAG-1 negatively affects LNCaP cell survival.
Positive_regulation (induction) of NAG-1 associated with apoptosis
13) Confidence 0.58 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15757899 Disease Relevance 0.34 Pain Relevance 0.18
In addition, an increase in NAG-1 is observed in inhibition of the AKT/GSK-3beta pathway, suggesting NAG-1 alters cell survival.
Positive_regulation (increase) of NAG-1
14) Confidence 0.58 Published 2006 Journal J. Biochem. Mol. Biol. Section Abstract Doc Link 17129398 Disease Relevance 0.88 Pain Relevance 0.13
These results suggest that induction of NAG-1 via Sp1 activation is a promising therapeutic approach in cancer treatment, and that a novel compound like LYR-8 could be a potent chemotherapeutic agent for colon cancers including p53-mutated cancer.
Positive_regulation (induction) of NAG-1 in colon associated with cancer, colon cancer and immunotherapy of cancer
15) Confidence 0.58 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20230799 Disease Relevance 1.06 Pain Relevance 0.10
Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) has recently been shown to be induced by nonsteroidal anti-inflammatory drugs (NSAIDs) and to have proapoptotic and antitumorigenic activities.
Positive_regulation (induced) of Nonsteroidal anti-inflammatory drug-activated gene-1 associated with inflammation and cinod
16) Confidence 0.58 Published 2008 Journal Int. J. Cancer Section Abstract Doc Link 18076062 Disease Relevance 0.75 Pain Relevance 0.65
The results suggest that I3C represses cell proliferation through up-regulation of NAG-1 and that ATF3 may play a pivotal role in DIM-induced NAG-1 expression in human colorectal cancer cells.
Positive_regulation (up-regulation) of NAG-1 associated with colon cancer
17) Confidence 0.58 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15670751 Disease Relevance 0.31 Pain Relevance 0.07
Additionally, the transcription factor early growth response-1 (Egr-1) gene was transcriptionally activated and the levels of non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) protein were elevated in platycodon D-treatedU937 cells.
Positive_regulation (elevated) of NAG-1 associated with inflammation and cinod
18) Confidence 0.51 Published 2009 Journal Biomed. Pharmacother. Section Abstract Doc Link 18804340 Disease Relevance 0.94 Pain Relevance 0.18
A novel anticancer effect of Astragalus saponins: Transcriptional activation of NSAID-activated gene.
Positive_regulation (activation) of NSAID-activated in Astragalus associated with cinod
19) Confidence 0.50 Published 2009 Journal Int. J. Cancer Section Title Doc Link 19384947 Disease Relevance 0.38 Pain Relevance 0.19
The induction of NAG-1 promoter activity by the drug was associated with increased gene expression, in addition to prior increase in Egr-1 expression and DNA binding activity.
Positive_regulation (induction) of NAG-1
20) Confidence 0.50 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19384947 Disease Relevance 0.41 Pain Relevance 0.15

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